| URN | urn:agi-llid:7360 |
|---|---|
| Connectivity | 1 |
| Name | Ugp2 |
| Description | UDP-glucose pyrophosphorylase 2 |
| Notes | The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. |
| Pathway | glycogen biosynthetic pathway |
|---|
| GO Molecular Function | transferase activity |
|---|---|
| pyrimidine ribonucleotide binding | |
| glucose binding | |
| metal ion binding | |
| nucleotidyltransferase activity | |
| UTP:glucose-1-phosphate uridylyltransferase activity |
| GO Cellular Component | soluble fraction |
|---|---|
| cytoplasm | |
| cytosol |
| GO Biological Process | metabolic process |
|---|---|
| UDP-glucuronate biosynthetic process | |
| glucose 1-phosphate metabolic process | |
| UDP-glucose metabolic process | |
| phosphorylation |
| Ariadne Ontology | Glycogen synthesis |
|---|
| Group | Glycogen synthesis |
|---|---|
| metabolic process | |
| UDP-glucuronate biosynthetic process | |
| glucose 1-phosphate metabolic process | |
| UDP-glucose metabolic process | |
| phosphorylation | |
| transferase activity | |
| pyrimidine ribonucleotide binding | |
| glucose binding | |
| metal ion binding | |
| nucleotidyltransferase activity | |
| UTP:glucose-1-phosphate uridylyltransferase activity | |
| soluble fraction | |
| cytoplasm | |
| cytosol |
| MedScan ID | 7360 |
|---|
| Hugo ID | 12527 |
|---|
| Human chromosome position | 2p14-p13 |
|---|
| LocusLink ID | 7360 |
|---|---|
| 216558 | |
| 289827 |
| Alias | UDPG |
|---|---|
| UGPP2 | |
| UDPGP2 | |
| pHC379 | |
| UTP--glucose-1-phosphate uridylyltransferase | |
| UDPGP | |
| UGPase 2 | |
| OTTHUMP00000214363 | |
| UDP-glucose diphosphorylase | |
| UTP-glucose-1-phosphate uridyltransferase | |
| UTP--glucose-1-phosphate uridylyltransferase 2 | |
| uridyl diphosphate glucose pyrophosphorylase 2 | |
| MGC38262 | |
| RP23-154K13.3 | |
| UGPase | |
| OTTMUSP00000005424 | |
| OTTMUSP00000005425 | |
| uridindiphosphoglucosepyrophosphorylase 2 | |
| UDP-glucose pyrophosphorylase 2 | |
| UGP1 | |
| UDP-glucose pyrophosphorylase II | |
| UDPGP 2 | |
| UDPGP II | |
| UGP2 | |
| UGPase II | |
| uridindiphosphoglucosepyrophosphorylase II | |
| uridyl diphosphate glucose pyrophosphorylase II | |
| UTP-glucose-1-phosphate uridylyltransferase 2 | |
| UTP-glucose-1-phosphate uridylyltransferase II | |
| UDPGP 2s | |
| pHC379s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 191760 |
|---|
| Mouse chromosome position | 11 12.0 cM |
|---|
| GO ID | 0003983 |
|---|---|
| 0046872 | |
| 0016779 | |
| 0016740 | |
| 0006011 | |
| 0006065 | |
| 0008152 | |
| 0016310 | |
| 0005737 | |
| 0005536 | |
| 0032557 | |
| 0019255 | |
| 0005625 | |
| 0005829 | |
| 0005515 | |
| 0003700 | |
| 0006355 |
| Rat chromosome position | 14q22 |
|---|
| Swiss-Prot Accession | Q16851 |
|---|---|
| Q53QE9 | |
| Q91ZJ5 | |
| Q3U548 | |
| Q8R0M2 | |
| Q4V8I9 | |
| Q5XFW3 | |
| Q07131 | |
| Q0P6K2 | |
| Q86Y81 | |
| Q9BU15 | |
| Q8R3D2 |
| PIR ID | S35692 |
|---|
| Unigene ID | Hs.516217 |
|---|---|
| Mm.28877 | |
| Rn.3415 |
| KEGG ID | hsa:7360 |
|---|---|
| mmu:216558 | |
| rno:289827 |
| EC Number | 2.7.7.9 |
|---|
| Swiss-Prot ID | UGPA_HUMAN |
|---|---|
| UGPA_MOUSE | |
| Q4V8I9_RAT |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00329331 |
|---|---|
| IPI00395676 | |
| IPI00131204 | |
| IPI00279474 | |
| IPI00362070 | |
| IPI00873223 |
| Homologene ID | 121676 |
|---|---|
| 4919 |
| RGD ID | 1310210 |
|---|
| MGI ID | 2183447 |
|---|