Protein Ptpn6

URN	urn:agi-llid:5777
Connectivity	510
Name	Ptpn6
Description	protein tyrosine phosphatase, non-receptor type 6
Notes	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]

Pathway	T-cell receptor -> AP-1 signaling
	T-cell receptor -> ATF/CREB signaling
	T-cell receptor -> CREBBP signaling
	T-cell receptor -> NF-kB signaling
	T-cell receptor -> NFATC signaling
	T-cell receptor -> STAT signaling
	angiotensin II signaling pathway via AT2 receptor

GO Molecular Function	hydrolase activity
	SH3 domain binding
	SH2 domain binding
	phosphotyrosine binding
	phosphatase activity
	phosphoprotein phosphatase activity
	protein tyrosine phosphatase activity
	receptor activity

GO Cellular Component	membrane
	cytoplasm
	cytosol
	nucleus
	alpha-beta T cell receptor complex

GO Biological Process	negative regulation of cell proliferation
	regulation of B cell differentiation
	signal transduction
	negative regulation of MAP kinase activity
	negative regulation of MAPKKK cascade
	negative regulation of T cell receptor signaling pathway
	negative regulation of peptidyl-tyrosine phosphorylation
	negative regulation of T cell proliferation
	natural killer cell mediated cytotoxicity
	protein amino acid dephosphorylation
	dephosphorylation
	apoptosis
	negative regulation of humoral immune response mediated by circulating immunoglobulin
	B cell receptor signaling pathway
	cytokine-mediated signaling pathway
	response to wounding
	intracellular signaling pathway
	G-protein coupled receptor protein signaling pathway

Ariadne Ontology	SHP1

Group	SHP1
	negative regulation of cell proliferation
	regulation of B cell differentiation
	signal transduction
	negative regulation of MAP kinase activity
	negative regulation of MAPKKK cascade
	negative regulation of T cell receptor signaling pathway
	negative regulation of peptidyl-tyrosine phosphorylation
	negative regulation of T cell proliferation
	natural killer cell mediated cytotoxicity
	protein amino acid dephosphorylation
	dephosphorylation
	apoptosis
	negative regulation of humoral immune response mediated by circulating immunoglobulin
	B cell receptor signaling pathway
	cytokine-mediated signaling pathway
	response to wounding
	intracellular signaling pathway
	G-protein coupled receptor protein signaling pathway
	hydrolase activity
	SH3 domain binding
	SH2 domain binding
	phosphotyrosine binding
	phosphatase activity
	phosphoprotein phosphatase activity
	protein tyrosine phosphatase activity
	receptor activity
	membrane
	cytoplasm
	cytosol
	nucleus
	alpha-beta T cell receptor complex

MedScan ID	5777

Hugo ID	9658

Human chromosome position	12p13

Alias	HCP
	HCPH
	SHP1
	SHP-1
	HPTP1C
	PTP-1C
	SHP-1L
	SH-PTP1
	tyrosine-protein phosphatase non-receptor type 6
	hematopoietic cell phosphatase
	protein-tyrosine phosphatase 1C
	protein-tyrosine phosphatase SHP-1
	hematopoietic cell protein-tyrosine phosphatase
	me
	Ptp1C
	motheaten
	70Z-SHP
	PTPTY-42
	hemopoietic cell phosphatase
	Ptph6
	MGC124580
	SH2 phosphatase 1
	70 kda SHP-1L protein
	hematopoietic cell phophatase
	hematopoietic phosphotyrosine phosphatase SHP-1
	motheaten protein
	protein tyrosine phosphatase, non-receptor type 6
	protein tyrosine phosphatase, non-receptor type VI
	PTP-1Cs
	PTPN6
	SH2 phosphatase I
	SH2-containing tyrosine phosphatase SHP-1
	SHP I
	SHP-1Ls
	SH-PTP I
	Src homology domain 2 (SH2)-containing tyrosine phosphatase-1
	Src homology domain 2-containing tyrosine phosphatase SHP-1

OMIM ID	176883

Mouse chromosome position	6 60.22 cM

Rat chromosome position	4q42

PIR ID	A44390
	B42031

EC Number	3.1.3.48

Cell Localization	Cytoplasm
	Nucleus

Homologene ID	56589

RGD ID	620660

MGI ID	96055