| URN | urn:agi-llid:2771 |
|---|---|
| Connectivity | 178 |
| Name | Gnai2 |
| Description | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
| Notes | The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq] |
| Pathway | CannabinoidR -> AP-1/EGR signaling |
|---|---|
| CholinergicRm -> CREB/ELK-SRF signaling | |
| NeuropeptideYR -> ATF/CREB signaling | |
| SerotoninR1 -> FOS signaling | |
| IL8R -> CREB/EGR signaling | |
| angiotensin II signaling pathway via AT2 receptor |
| GO Molecular Function | signal transducer activity |
|---|---|
| nucleotide binding | |
| guanyl nucleotide binding | |
| GTP binding | |
| GTPase activity |
| GO Cellular Component | plasma membrane |
|---|---|
| membrane raft | |
| cytosol | |
| nucleus | |
| membrane fraction |
| GO Biological Process | cell proliferation |
|---|---|
| positive regulation of cell proliferation | |
| negative regulation of synaptic transmission | |
| regulation of heart contraction | |
| signal transduction | |
| intracellular protein kinase cascade | |
| inhibition of adenylate cyclase activity by G-protein signaling pathway | |
| negative regulation of adenylate cyclase activity | |
| activation of MAPKK activity | |
| negative regulation of calcium ion transport via voltage-gated calcium channel activity | |
| response to nutrient | |
| G-protein coupled receptor protein signaling pathway | |
| muscarinic acetylcholine receptor signaling pathway | |
| adenosine receptor signaling pathway | |
| gamma-aminobutyric acid signaling pathway | |
| metabotropic glutamate receptor signaling pathway |
| Ariadne Ontology | Gi-o |
|---|
| Group | Gi-o |
|---|---|
| cell proliferation | |
| positive regulation of cell proliferation | |
| negative regulation of synaptic transmission | |
| regulation of heart contraction | |
| signal transduction | |
| intracellular protein kinase cascade | |
| inhibition of adenylate cyclase activity by G-protein signaling pathway | |
| negative regulation of adenylate cyclase activity | |
| activation of MAPKK activity | |
| negative regulation of calcium ion transport via voltage-gated calcium channel activity | |
| response to nutrient | |
| G-protein coupled receptor protein signaling pathway | |
| muscarinic acetylcholine receptor signaling pathway | |
| adenosine receptor signaling pathway | |
| gamma-aminobutyric acid signaling pathway | |
| metabotropic glutamate receptor signaling pathway | |
| signal transducer activity | |
| nucleotide binding | |
| guanyl nucleotide binding | |
| GTP binding | |
| GTPase activity | |
| plasma membrane | |
| membrane raft | |
| cytosol | |
| nucleus | |
| membrane fraction |
| MedScan ID | 2771 |
|---|
| Hugo ID | 4385 |
|---|
| Human chromosome position | 3p21 |
|---|
| LocusLink ID | 2771 |
|---|---|
| 14678 | |
| 81664 |
| Alias | GIP |
|---|---|
| GNAI2B | |
| H_LUCA15.1 | |
| H_LUCA16.1 | |
| guanine nucleotide-binding protein G(i) subunit alpha-2 | |
| OTTHUMP00000211066 | |
| OTTHUMP00000211067 | |
| OTTHUMP00000211070 | |
| adenylate cyclase-inhibiting G alpha protein | |
| GTP-binding regulatory protein Gi alpha-2 chain | |
| guanine nucleotide-binding protein G(i), alpha-2 subunit | |
| Gia | |
| C76432 | |
| Gnai-2 | |
| Galphai2 | |
| guanine nucleotide binding protein, alpha inhibiting 2 | |
| G alpha inhibitory type 2 (a) | |
| G alpha inhibitory type 2 (b) | |
| GTP-binding protein (G-alpha-i2) | |
| Adenylate cyclase-inhibiting G alpha protein 2 | |
| Adenylate cyclase-inhibiting G alpha protein II | |
| G alpha i2 | |
| g alpha inhibitory type 2 | |
| G protein alpha inhibiting activity polypeptide 2 | |
| G protein alpha inhibiting activity polypeptide II | |
| G(i), alpha II | |
| G(i), alpha-2 | |
| G(i2) | |
| GBI2 | |
| GBI2_HUMAN | |
| Gnai2 | |
| GTP-binding regulatory Gi alpha-2 chain | |
| GTP-binding regulatory protein Gi alpha-2 chain (adenylate | |
| guanine nucleotide binding protein (G protein), alpha inhibiting 2 | |
| guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | |
| guanine nucleotide binding protein, alpha inhibiting II | |
| Guanine nucleotide-binding protein (G protein), alpha-inhibiting | |
| WUGSC:H_LUCA15.1 | |
| WUGSC:H_LUCA16.1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 139360 |
|---|---|
| 192605 |
| Mouse chromosome position | 9 59.0 cM |
|---|
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0019001 | |
| 0000166 | |
| 0004871 | |
| 0007186 | |
| 0000186 | |
| 0001973 | |
| 0007214 | |
| 0007193 | |
| 0007243 | |
| 0007213 | |
| 0007194 | |
| 0051927 | |
| 0050805 | |
| 0008284 | |
| 0007584 | |
| 0007165 | |
| 0005829 | |
| 0005624 | |
| 0045121 | |
| 0005634 | |
| 0005886 | |
| 0008283 | |
| 0007216 | |
| 0008016 |
| Rat chromosome position | 8q32 |
|---|
| Swiss-Prot Accession | B3KP24 |
|---|---|
| B3KX51 | |
| B4DYA0 | |
| P04899 | |
| Q6B6N3 | |
| Q6LCB5 | |
| Q93020 | |
| Q96C71 | |
| P08752 | |
| Q3TXK7 | |
| Q8JZT4 | |
| Q922Y6 | |
| P04897 | |
| Q45QN0 | |
| Q5EEY3 | |
| Q5EEY4 | |
| Q6P1C0 | |
| Q8IZ71 |
| PIR ID | B25889 |
|---|---|
| S02319 | |
| D27423 |
| Unigene ID | Hs.77269 |
|---|---|
| Mm.196464 | |
| Rn.3036 |
| KEGG ID | hsa:2771 |
|---|---|
| mmu:14678 | |
| rno:81664 |
| Swiss-Prot ID | GNAI2_MOUSE |
|---|---|
| GNAI2_HUMAN | |
| GNAI2_RAT | |
| B3KP24_HUMAN | |
| B3KX51_HUMAN | |
| B4DYA0_HUMAN | |
| Q45QN0_RAT | |
| Q3TXK7_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00228617 |
|---|---|
| IPI00217906 | |
| IPI00748145 | |
| IPI00231925 | |
| IPI00924427 | |
| IPI00925691 | |
| IPI00652902 | |
| IPI00794986 | |
| IPI00465121 | |
| IPI00796250 | |
| IPI00798195 | |
| IPI00797567 |
| Homologene ID | 55539 |
|---|
| RGD ID | 620243 |
|---|
| MGI ID | 95772 |
|---|