| URN | urn:agi-llid:5997 |
|---|---|
| Total Entities | 0 |
| Connectivity | 437 |
| Name | Rgs2 |
| Description | regulator of G-protein signaling 2, 24kDa |
| Notes | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq] |
| Ariadne Ontology | RGS |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | calmodulin binding |
|---|---|
| GTPase activator activity |
| GO Cellular Component | membrane |
|---|---|
| nucleolus | |
| internal side of plasma membrane | |
| plasma membrane | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | cell cycle |
|---|---|
| negative regulation of signal transduction | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| negative regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| regulation of adrenergic receptor signaling pathway | |
| negative regulation of MAP kinase activity | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of GTPase activity | |
| regulation of translation | |
| brown fat cell differentiation | |
| negative regulation of cardiac muscle hypertrophy | |
| relaxation of vascular smooth muscle | |
| positive regulation of cardiac muscle contraction | |
| negative regulation of phospholipase activity | |
| relaxation of cardiac muscle | |
| spermatogenesis |
| Pathway | angiotensin II signaling pathway via AT1 receptor |
|---|---|
| angiotensin II signaling pathway via AT1 receptor |
| Group | RGS |
|---|---|
| cell cycle | |
| negative regulation of signal transduction | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| negative regulation of G-protein coupled receptor protein signaling pathway | |
| termination of G-protein coupled receptor signaling pathway | |
| regulation of adrenergic receptor signaling pathway | |
| negative regulation of MAP kinase activity | |
| G-protein coupled receptor signaling pathway | |
| positive regulation of GTPase activity | |
| regulation of translation | |
| brown fat cell differentiation | |
| negative regulation of cardiac muscle hypertrophy | |
| relaxation of vascular smooth muscle | |
| positive regulation of cardiac muscle contraction | |
| negative regulation of phospholipase activity | |
| relaxation of cardiac muscle | |
| spermatogenesis | |
| calmodulin binding | |
| GTPase activator activity | |
| membrane | |
| nucleolus | |
| internal side of plasma membrane | |
| plasma membrane | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5997 |
|---|
| Hugo ID | 9998 |
|---|
| Human chromosome position | 1q31 |
|---|
| LocusLink ID | 5997 |
|---|---|
| 19735 | |
| 84583 |
| Alias | G0S8 |
|---|---|
| GIG31 | |
| regulator of G-protein signaling 2 | |
| G0/G1 switch regulatory protein 8 | |
| cell growth-inhibiting protein 31 | |
| G0 to G1 switch regulatory 8, 24kD | |
| cell growth-inhibiting gene 31 protein | |
| GOS8 | |
| AL592303.1 | |
| regulator of G-protein signaling protein 2 | |
| OTTMUSP00000022856 | |
| regulator of G-protein signaling 2, 24kDa | |
| Regulator of G-protein signaling II | |
| regulator of g-protein signalling 2 | |
| regulator of G-protein signalling 2, 24kD | |
| regulator of G-protein signalling 2, 24kDa | |
| OTTHUMP00000060765 | |
| Rgs2 | |
| OTTHUMP00000033592 | |
| G0/G1 switch regulatory protein VIII | |
| 24 kDa G0 to G1 switch regulatory VIII | |
| 24 kDa G0 to G1 switch regulatory 8 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600861 |
|---|
| Unigene ID | Hs.78944 |
|---|---|
| Mm.28262 | |
| Rn.1892 |
| KEGG ID | hsa:5997 |
|---|---|
| mmu:19735 | |
| rno:84583 |
| Swiss-Prot Accession | P41220 |
|---|---|
| B1AVP8 | |
| O08849 | |
| Q9JHX0 | |
| Q544S7 | |
| Q91WX1 | |
| Q9JL24 | |
| Q6I9U5 | |
| Q49A86 |
| GO ID | 0005096 |
|---|---|
| 0005516 | |
| 0050873 | |
| 0007049 | |
| 0045744 | |
| 0043407 | |
| 0010614 | |
| 0010519 | |
| 0043547 | |
| 0060452 | |
| 0008277 | |
| 0071877 | |
| 0006417 | |
| 0055119 | |
| 0060087 | |
| 0007283 | |
| 0038032 | |
| 0005737 | |
| 0005829 | |
| 0009898 | |
| 0005739 | |
| 0005730 | |
| 0005886 | |
| 0007186 | |
| 0009968 | |
| 0016020 | |
| 0005634 | |
| 0004871 |
| PIR ID | I53020 |
|---|
| Swiss-Prot ID | RGS2_RAT |
|---|---|
| RGS2_MOUSE | |
| RGS2_HUMAN | |
| B1AVP8_MOUSE |
| Cell Localization | Cell membrane |
|---|---|
| Cytoplasm | |
| Nucleus | |
| nucleolus | |
| Mitochondrion |
| IPI ID | IPI00200023 |
|---|---|
| IPI00309304 | |
| IPI00013177 | |
| IPI01017891 | |
| IPI01017975 | |
| IPI01018248 |
| Mouse chromosome position | 1 78.0 cM |
|---|
| Rat chromosome position | 13q21 |
|---|
| Homologene ID | 2192 |
|---|
| MGI ID | 1098271 |
|---|
| RGD ID | 621665 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|