| URN | urn:agi-llid:408 |
|---|---|
| Total Entities | 0 |
| Connectivity | 705 |
| Name | Arrb1 |
| Description | arrestin, beta 1 |
| Notes | Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | ion channel binding |
|---|---|
| phosphoprotein binding | |
| clathrin binding | |
| transcription factor binding | |
| AP-2 adaptor complex binding | |
| G-protein coupled receptor binding | |
| insulin-like growth factor receptor binding | |
| angiotensin receptor binding | |
| follicle-stimulating hormone receptor binding | |
| alpha-1A adrenergic receptor binding | |
| alpha-1B adrenergic receptor binding | |
| V2 vasopressin receptor binding | |
| estrogen receptor binding | |
| mitogen-activated protein kinase kinase binding | |
| ubiquitin protein ligase binding | |
| clathrin adaptor activity | |
| protein phosphorylated amino acid binding | |
| transcription regulatory region DNA binding | |
| histone acetyltransferase activity | |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | |
| GTPase activator activity | |
| enzyme inhibitor activity |
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| lysosomal membrane | |
| cytoplasmic vesicle membrane | |
| chromatin | |
| postsynaptic density | |
| coated pit | |
| basolateral plasma membrane | |
| heterotrimeric G-protein complex | |
| plasma membrane | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle | |
| nucleus | |
| dendritic spine | |
| pseudopodium | |
| postsynaptic membrane |
| GO Biological Process | cellular membrane organization |
|---|---|
| follicle-stimulating hormone signaling pathway | |
| negative regulation of signal transduction | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of Rho protein signal transduction | |
| activation of MAPK activity | |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus | |
| signal transduction | |
| phototransduction | |
| G-protein coupled receptor signaling pathway | |
| Notch signaling pathway | |
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | |
| regulation of cAMP catabolic process | |
| negative regulation of GTPase activity | |
| positive regulation of GTPase activity | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein ubiquitination | |
| positive regulation of histone acetylation | |
| positive regulation of histone H4 acetylation | |
| negative regulation of protein phosphorylation | |
| negative regulation of protein ubiquitination | |
| regulation of transcription, DNA-dependent | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of cAMP biosynthetic process | |
| positive regulation of smooth muscle cell apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| platelet activation | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| G-protein coupled receptor internalization | |
| histone H4 acetylation | |
| protein ubiquitination | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| stress fiber assembly | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-8 production | |
| sensory perception of pain | |
| sensory perception of touch | |
| blood coagulation | |
| transport | |
| post-Golgi vesicle-mediated transport | |
| protein transport | |
| endocytosis | |
| positive regulation of protein binding |
| Pathway | AdrenergicRb -> CREB signaling |
|---|---|
| AdrenergicRb -> STAT3 signaling | |
| Epinephrine/Gs Expression Targets | |
| Noradrenaline/Gs Expression Targets | |
| angiotensin II signaling pathway via AT1 receptor | |
| corticotropin-releasing hormone signaling pathway | |
| calcium signaling pathway via the calcium-sensing receptor | |
| parathyroid hormone signaling pathway | |
| kinin signaling pathway first | |
| kinin signaling pathway | |
| epinephrine signaling pathway via adrenergic receptor beta | |
| epinephrine signaling pathway via adrenergic receptor beta | |
| angiotensin II signaling pathway via AT1 receptor | |
| kinin signaling pathway |
| Group | cellular membrane organization |
|---|---|
| follicle-stimulating hormone signaling pathway | |
| negative regulation of signal transduction | |
| regulation of G-protein coupled receptor protein signaling pathway | |
| desensitization of G-protein coupled receptor protein signaling pathway by arrestin | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of Rho protein signal transduction | |
| activation of MAPK activity | |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus | |
| signal transduction | |
| phototransduction | |
| G-protein coupled receptor signaling pathway | |
| Notch signaling pathway | |
| adenylate cyclase-modulating G-protein coupled receptor signaling pathway | |
| regulation of cAMP catabolic process | |
| negative regulation of GTPase activity | |
| positive regulation of GTPase activity | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of protein ubiquitination | |
| positive regulation of histone acetylation | |
| positive regulation of histone H4 acetylation | |
| negative regulation of protein phosphorylation | |
| negative regulation of protein ubiquitination | |
| regulation of transcription, DNA-dependent | |
| negative regulation of NF-kappaB transcription factor activity | |
| regulation of cAMP biosynthetic process | |
| positive regulation of smooth muscle cell apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| platelet activation | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| G-protein coupled receptor internalization | |
| histone H4 acetylation | |
| protein ubiquitination | |
| proteasomal ubiquitin-dependent protein catabolic process | |
| stress fiber assembly | |
| negative regulation of interleukin-6 production | |
| negative regulation of interleukin-8 production | |
| sensory perception of pain | |
| sensory perception of touch | |
| blood coagulation | |
| transport | |
| post-Golgi vesicle-mediated transport | |
| protein transport | |
| endocytosis | |
| positive regulation of protein binding | |
| ion channel binding | |
| phosphoprotein binding | |
| clathrin binding | |
| transcription factor binding | |
| AP-2 adaptor complex binding | |
| G-protein coupled receptor binding | |
| insulin-like growth factor receptor binding | |
| angiotensin receptor binding | |
| follicle-stimulating hormone receptor binding | |
| alpha-1A adrenergic receptor binding | |
| alpha-1B adrenergic receptor binding | |
| V2 vasopressin receptor binding | |
| estrogen receptor binding | |
| mitogen-activated protein kinase kinase binding | |
| ubiquitin protein ligase binding | |
| clathrin adaptor activity | |
| protein phosphorylated amino acid binding | |
| transcription regulatory region DNA binding | |
| histone acetyltransferase activity | |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | |
| GTPase activator activity | |
| enzyme inhibitor activity | |
| membrane | |
| Golgi membrane | |
| lysosomal membrane | |
| cytoplasmic vesicle membrane | |
| chromatin | |
| postsynaptic density | |
| coated pit | |
| basolateral plasma membrane | |
| heterotrimeric G-protein complex | |
| plasma membrane | |
| cell projection | |
| intracellular | |
| cytoplasm | |
| cytoplasmic vesicle | |
| cytosol | |
| cytoplasmic membrane-bounded vesicle | |
| nucleus | |
| dendritic spine | |
| pseudopodium | |
| postsynaptic membrane | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 408 |
|---|
| Hugo ID | 711 |
|---|
| Human chromosome position | 11q13 |
|---|
| LocusLink ID | 408 |
|---|---|
| 109689 | |
| 25387 |
| Alias | ARB1 |
|---|---|
| ARR1 | |
| beta-arrestin-1 | |
| arrestin 2 | |
| AW208571 | |
| 1200006I17Rik | |
| G430100A01Rik | |
| beta-arrestin1 | |
| arrestin beta-1 | |
| arrestin, beta 1, isoform B | |
| BARRES | |
| arrestin, beta | |
| ARRB I | |
| MGC124269 | |
| G430100A01 | |
| beta-arrestin I | |
| beta-arrestin 1 | |
| beta-arrestin | |
| MGC124270 | |
| arrestin beta 1 isoform B | |
| arrestin beta 1 isoform A | |
| 1200006I17 | |
| ARRB1 | |
| arrestin beta 1 | |
| ARR I | |
| ARB I | |
| arrestin beta I | |
| arrestin, beta 1 | |
| RIKEN cDNA G430100A01 gene | |
| RIKEN cDNA 1200006I17 gene | |
| arrestin 1 | |
| arrestin I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 107940 |
|---|
| Unigene ID | Hs.503284 |
|---|---|
| Hs.625320 | |
| Mm.260193 | |
| Rn.34876 |
| KEGG ID | hsa:408 |
|---|---|
| mmu:109689 | |
| rno:25387 |
| Swiss-Prot Accession | B7Z1Q3 |
|---|---|
| P49407 | |
| Q8BWG8 | |
| P29066 | |
| B6V9G8 | |
| O75625 | |
| O75630 | |
| Q2PP20 | |
| Q9BTK8 | |
| Q3UH95 | |
| Q8BTJ5 | |
| Q3U172 |
| GO ID | 0005096 |
|---|---|
| 0031701 | |
| 0043027 | |
| 0004857 | |
| 0004402 | |
| 0005159 | |
| 0031434 | |
| 0008134 | |
| 0044212 | |
| 0031625 | |
| 0002031 | |
| 0007219 | |
| 0007596 | |
| 0016044 | |
| 0032088 | |
| 0032715 | |
| 0032717 | |
| 0031397 | |
| 0007602 | |
| 0030168 | |
| 0070374 | |
| 0043547 | |
| 0035025 | |
| 0090240 | |
| 0035066 | |
| 0035774 | |
| 0033138 | |
| 0032092 | |
| 0045944 | |
| 0006892 | |
| 0043161 | |
| 0015031 | |
| 0016567 | |
| 0043149 | |
| 0006366 | |
| 0000139 | |
| 0000785 | |
| 0005905 | |
| 0005737 | |
| 0031410 | |
| 0030659 | |
| 0005829 | |
| 0005834 | |
| 0005765 | |
| 0005634 | |
| 0005886 | |
| 0031143 | |
| 0035612 | |
| 0031896 | |
| 0031691 | |
| 0031692 | |
| 0035615 | |
| 0030331 | |
| 0031762 | |
| 0044325 | |
| 0051219 | |
| 0045309 | |
| 0007186 | |
| 0000187 | |
| 0006897 | |
| 0042699 | |
| 0034260 | |
| 0043154 | |
| 0001933 | |
| 0009968 | |
| 0031398 | |
| 0034393 | |
| 0008277 | |
| 0006355 | |
| 0007165 | |
| 0006351 | |
| 0006810 | |
| 0016323 | |
| 0042995 | |
| 0043197 | |
| 0005622 | |
| 0016020 | |
| 0014069 | |
| 0045211 | |
| 0001664 | |
| 0030276 | |
| 0007188 | |
| 0002032 | |
| 0030817 | |
| 0030820 | |
| 0019233 | |
| 0050975 | |
| 0016023 | |
| 0045767 | |
| 0043967 | |
| 0010843 | |
| 0010552 | |
| 0045449 | |
| 0007600 | |
| 0005624 | |
| 0005625 | |
| 0006350 | |
| 0005515 | |
| 0050896 |
| PIR ID | B46682 |
|---|---|
| B43404 |
| Swiss-Prot ID | ARRB1_HUMAN |
|---|---|
| ARRB1_RAT | |
| ARRB1_MOUSE | |
| B6V9G8_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Cell membrane | |
| Membrane | |
| clathrin-coated pit | |
| Cell projection | |
| pseudopodium | |
| Cytoplasmic vesicle |
| IPI ID | IPI00293857 |
|---|---|
| IPI00336017 | |
| IPI00200580 | |
| IPI00274186 | |
| IPI00761566 | |
| IPI00777900 | |
| IPI00781876 |
| Mouse chromosome position | 7 50.0 cM |
|---|
| Rat chromosome position | 1q32 |
|---|
| Homologene ID | 2981 |
|---|
| MGI ID | 99473 |
|---|
| RGD ID | 2156 |
|---|