| URN | urn:agi-llid:185 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1848 |
| Name | Agtr1 |
| Description | angiotensin II receptor, type 1 |
| Notes | Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq] |
| Ariadne Ontology | GPCR-G12CR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | G-protein alpha-subunit binding |
|---|---|
| protein self-association | |
| bradykinin receptor binding | |
| protein kinase binding | |
| protein heterodimerization activity | |
| peptide hormone binding | |
| acetyltransferase activator activity | |
| G-protein coupled receptor activity | |
| angiotensin type II receptor activity | |
| angiotensin type I receptor activity | |
| signal transducer activity |
| GO Cellular Component | membrane |
|---|---|
| organelle outer membrane | |
| vesicle membrane | |
| vesicle lumen | |
| basolateral plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| endomembrane system | |
| cytoplasm | |
| cytoplasmic vesicle | |
| endosome | |
| Golgi apparatus | |
| recycling endosome | |
| dendrite |
| GO Biological Process | signal transduction |
|---|---|
| regulation of cell growth | |
| regulation of cell proliferation | |
| Rho protein signal transduction | |
| calcium-mediated signaling | |
| G-protein coupled receptor signaling pathway | |
| angiotensin-mediated signaling pathway | |
| phospholipase C-activating G-protein coupled receptor signaling pathway | |
| phospholipase C-activating angiotensin-mediated signaling pathway | |
| positive regulation of receptor recycling | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of cholesterol esterification | |
| positive regulation of reactive oxygen species metabolic process | |
| activation of Janus kinase activity | |
| positive regulation of superoxide anion generation | |
| negative regulation of neuron apoptotic process | |
| negative regulation of smooth muscle cell apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of cytokine secretion | |
| regulation of smooth muscle cell apoptotic process | |
| renin secretion into blood stream | |
| dopamine biosynthetic process | |
| elevation of cytosolic calcium ion concentration | |
| elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | |
| cell chemotaxis | |
| cellular response to dexamethasone stimulus | |
| response to estrogen stimulus | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| drinking behavior | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| regulation of vasoconstriction | |
| regulation of vasodilation | |
| regulation of renal sodium excretion | |
| positive regulation of phospholipase A2 activity | |
| positive regulation of NAD(P)H oxidase activity | |
| aging | |
| blood vessel development | |
| kidney development | |
| heart development | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| vasoconstriction | |
| renin-angiotensin regulation of aldosterone production | |
| low-density lipoprotein particle remodeling | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| regulation of pH |
| Pathway | AngiotensinR -> STAT signaling |
|---|---|
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| Bextra-Induced Ischemic Disease | |
| ROS and RNS in Regulation of Vasoconstriction and Vasodilation | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| ROS in Triggering Vascular Inflammation | |
| Erythropoietin/NF-kB Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| EGF/TP53 Expression Targets | |
| AGT/TP53 Expression Targets | |
| AGT/ELK-SRF Expression Targets | |
| IGF1/STAT Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/STAT Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| EGF/CTNN Expression Targets | |
| renin-angiotensin system signaling pathway | |
| angiotensin II signaling pathway | |
| angiotensin II signaling pathway via AT1 receptor | |
| renin-angiotensin cascade pathway | |
| losartan pharmacodynamics pathway | |
| angiotensin II signaling pathway via AT1 receptor |
| Group | GPCR-G12CR |
|---|---|
| signal transduction | |
| regulation of cell growth | |
| regulation of cell proliferation | |
| Rho protein signal transduction | |
| calcium-mediated signaling | |
| G-protein coupled receptor signaling pathway | |
| angiotensin-mediated signaling pathway | |
| phospholipase C-activating G-protein coupled receptor signaling pathway | |
| phospholipase C-activating angiotensin-mediated signaling pathway | |
| positive regulation of receptor recycling | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of cholesterol esterification | |
| positive regulation of reactive oxygen species metabolic process | |
| activation of Janus kinase activity | |
| positive regulation of superoxide anion generation | |
| negative regulation of neuron apoptotic process | |
| negative regulation of smooth muscle cell apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of cytokine secretion | |
| regulation of smooth muscle cell apoptotic process | |
| renin secretion into blood stream | |
| dopamine biosynthetic process | |
| elevation of cytosolic calcium ion concentration | |
| elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | |
| cell chemotaxis | |
| cellular response to dexamethasone stimulus | |
| response to estrogen stimulus | |
| inflammatory response | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| drinking behavior | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| regulation of vasoconstriction | |
| regulation of vasodilation | |
| regulation of renal sodium excretion | |
| positive regulation of phospholipase A2 activity | |
| positive regulation of NAD(P)H oxidase activity | |
| aging | |
| blood vessel development | |
| kidney development | |
| heart development | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by renin-angiotensin | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| vasoconstriction | |
| renin-angiotensin regulation of aldosterone production | |
| low-density lipoprotein particle remodeling | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| regulation of pH | |
| G-protein alpha-subunit binding | |
| protein self-association | |
| bradykinin receptor binding | |
| protein kinase binding | |
| protein heterodimerization activity | |
| peptide hormone binding | |
| acetyltransferase activator activity | |
| G-protein coupled receptor activity | |
| angiotensin type II receptor activity | |
| angiotensin type I receptor activity | |
| signal transducer activity | |
| membrane | |
| organelle outer membrane | |
| vesicle membrane | |
| vesicle lumen | |
| basolateral plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| endomembrane system | |
| cytoplasm | |
| cytoplasmic vesicle | |
| endosome | |
| Golgi apparatus | |
| recycling endosome | |
| dendrite | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 185 |
|---|
| Hugo ID | 336 |
|---|
| Human chromosome position | 3q24 |
|---|---|
| 3q21-q25 |
| LocusLink ID | 185 |
|---|---|
| 11607 | |
| 24180 |
| Alias | AT1 |
|---|---|
| AG2S | |
| AT1B | |
| AT1R | |
| AT1AR | |
| AT1BR | |
| AT2R1 | |
| HAT1R | |
| AGTR1A | |
| AGTR1B | |
| AT2R1A | |
| AT2R1B | |
| type-1 angiotensin II receptor | |
| type-1B angiotensin II receptor | |
| AT1a | |
| Agtr1 | |
| Agtr-1a | |
| AI551199 | |
| Angtr-1a | |
| 1810074K20Rik | |
| type-1A angiotensin II receptor | |
| angiotensin receptor 1 | |
| angiotensin receptor 1a | |
| angiotensin II type-1A receptor | |
| vascular type-1 angiotensin II receptor | |
| AT1A receptors | |
| AT1A receptor | |
| AT2R I | |
| AT1 receptor | |
| OTTMUSP00000000614 | |
| AT(1) | |
| Angtr-1b | |
| AT1 receptors | |
| MGC37610 | |
| Type-1 angiotensin II receptors | |
| type-1B angiotensin II receptors | |
| Angiotensin II receptor, type 1 (AT1B) | |
| 1810074K20 | |
| AGTR I | |
| angiotensin II receptor, type 1b | |
| angiotensin type 1 receptor | |
| ANG type 1 receptor | |
| angiotensin AT(1)-receptor | |
| angiotensin AT(1)-receptors | |
| angiotensin receptor 1b | |
| angiotensin receptor I | |
| angiotensin II receptor, type 1 | |
| angiotensin II type-1B receptor | |
| angiotensin II type-1 receptors | |
| angiotensin II type-1 receptor | |
| angiotensin II receptor, type I | |
| angiotensin II receptor, type 1a |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 106165 |
|---|---|
| 145500 | |
| 267430 |
| Unigene ID | Hs.477887 |
|---|---|
| Hs.740357 | |
| Mm.35062 | |
| Rn.9814 | |
| Hs.723124 | |
| Mm.477038 | |
| Rn.214849 |
| KEGG ID | hsa:185 |
|---|---|
| mmu:11607 | |
| rno:24180 |
| Swiss-Prot Accession | P30556 |
|---|---|
| Q53YY0 | |
| D3DNG8 | |
| P29754 | |
| P25095 | |
| Q9QVS5 | |
| Q13725 | |
| Q13063 | |
| Q6NUP5 | |
| Q8TBK4 |
| GO ID | 0010698 |
|---|---|
| 0001596 | |
| 0004945 | |
| 0031711 | |
| 0046982 | |
| 0007186 | |
| 0007266 | |
| 0019722 | |
| 0060326 | |
| 0007204 | |
| 0051482 | |
| 0001822 | |
| 0034374 | |
| 0007200 | |
| 0086097 | |
| 0033864 | |
| 0032270 | |
| 0010873 | |
| 0050729 | |
| 0010744 | |
| 0032430 | |
| 2000379 | |
| 0002034 | |
| 0001558 | |
| 0042127 | |
| 0050727 | |
| 0035813 | |
| 0003081 | |
| 0019229 | |
| 0042312 | |
| 0002018 | |
| 0016021 | |
| 0005887 | |
| 0005886 | |
| 0001965 | |
| 0004930 | |
| 0017046 | |
| 0019901 | |
| 0043621 | |
| 0004871 | |
| 0042976 | |
| 0038166 | |
| 0001568 | |
| 0002035 | |
| 0071549 | |
| 0042416 | |
| 0042756 | |
| 0007507 | |
| 0006954 | |
| 0043524 | |
| 0034392 | |
| 0045777 | |
| 0090190 | |
| 0008284 | |
| 0050715 | |
| 0001921 | |
| 0032930 | |
| 0006885 | |
| 0002019 | |
| 0034391 | |
| 0001991 | |
| 0002001 | |
| 0043627 | |
| 0007165 | |
| 0042310 | |
| 0005794 | |
| 0016323 | |
| 0005737 | |
| 0031410 | |
| 0030425 | |
| 0012505 | |
| 0005768 | |
| 0016020 | |
| 0031968 | |
| 0055037 | |
| 0031983 | |
| 0012506 | |
| 0007568 | |
| 0008217 | |
| 0004872 | |
| 0006800 | |
| 0003078 | |
| 0004947 | |
| 0016494 |
| PIR ID | JH0621 |
|---|---|
| JC2134 | |
| I39418 | |
| JC1104 |
| Swiss-Prot ID | AGTRA_MOUSE |
|---|---|
| AGTRA_RAT | |
| AGTR1_HUMAN | |
| Q53YY0_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00129168 |
|---|---|
| IPI00327967 | |
| IPI00797565 | |
| IPI00026885 |
| Mouse chromosome position | 13 16.0 cM |
|---|
| Rat chromosome position | 17q12 |
|---|
| Homologene ID | 3556 |
|---|
| MGI ID | 87964 |
|---|
| RGD ID | 2070 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|