| URN | urn:agi-llid:3717 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1422 |
| Name | Jak2 |
| Description | Janus kinase 2 |
| Notes | associated with receptors for erythropoietin, prolactin, growth hormones and interleukin-3; phosphorylated when activated by cytokines [RGD] |
| Ariadne Ontology | JAK |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | receptor binding |
|---|---|
| phosphatidylinositol 3-kinase binding | |
| protein C-terminus binding | |
| insulin receptor substrate binding | |
| histone binding | |
| acetylcholine receptor binding | |
| interleukin-12 receptor binding | |
| growth hormone receptor binding | |
| type 1 angiotensin receptor binding | |
| peptide hormone receptor binding | |
| protein kinase binding | |
| SH2 domain binding | |
| nucleotide binding | |
| ATP binding | |
| heme binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity | |
| histone kinase activity (H3-Y41 specific) |
| GO Cellular Component | membrane |
|---|---|
| nuclear matrix | |
| endosome lumen | |
| membrane raft | |
| caveola | |
| endomembrane system | |
| cytoplasm | |
| cytosol | |
| cytoskeleton | |
| nucleus |
| GO Biological Process | cellular component movement |
|---|---|
| regulation of interferon-gamma-mediated signaling pathway | |
| positive regulation of phosphatidylinositol 3-kinase cascade | |
| positive regulation of growth hormone receptor signaling pathway | |
| positive regulation of tyrosine phosphorylation of Stat5 protein | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| activation of MAPKK activity | |
| activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | |
| positive regulation of insulin secretion | |
| signal transduction | |
| intracellular signal transduction | |
| hormone-mediated signaling pathway | |
| mineralocorticoid receptor signaling pathway | |
| intracellular protein kinase cascade | |
| JAK-STAT cascade | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| intrinsic apoptotic signaling pathway in response to oxidative stress | |
| cytokine-mediated signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| enzyme linked receptor protein signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| interferon-gamma-mediated signaling pathway | |
| interleukin-12-mediated signaling pathway | |
| platelet-derived growth factor receptor signaling pathway | |
| growth hormone receptor signaling pathway | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| activation of JAK2 kinase activity | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of phosphoprotein phosphatase activity | |
| negative regulation of cell proliferation | |
| negative regulation of cell-cell adhesion | |
| negative regulation of neuron apoptotic process | |
| positive regulation of cell activation | |
| positive regulation of cell differentiation | |
| positive regulation of cell proliferation | |
| positive regulation of cell migration | |
| positive regulation of cell-substrate adhesion | |
| positive regulation of apoptotic process | |
| positive regulation of protein import into nucleus, translocation | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| cell differentiation | |
| axon regeneration | |
| myeloid cell differentiation | |
| erythrocyte differentiation | |
| protein phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| protein autophosphorylation | |
| tyrosine phosphorylation of STAT protein | |
| tyrosine phosphorylation of Stat3 protein | |
| tyrosine phosphorylation of Stat5 protein | |
| tyrosine phosphorylation of Stat1 protein | |
| histone H3-Y41 phosphorylation | |
| phosphorylation | |
| STAT protein import into nucleus | |
| elevation of cytosolic calcium ion concentration | |
| apoptotic process | |
| actin filament polymerization | |
| chromatin modification | |
| innate immune response | |
| response to hydroperoxide | |
| response to lipopolysaccharide | |
| response to interleukin-12 | |
| response to granulocyte macrophage colony-stimulating factor stimulus | |
| response to tumor necrosis factor | |
| response to antibiotic | |
| response to oxidative stress | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| negative regulation of heart contraction | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interleukin-1 beta production | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| mesoderm development | |
| mammary gland epithelium development | |
| blood coagulation | |
| negative regulation of DNA binding | |
| positive regulation of DNA binding |
| Pathway | ErythropoietinR -> AP-1/CREB/MYC signaling |
|---|---|
| ErythropoietinR -> FOXO3A signaling | |
| TNFRSF1A -> STAT signaling | |
| T-cell receptor -> STAT signaling | |
| EGFR/ERBB -> STAT signaling | |
| FGFR3 -> STAT signaling | |
| FGFR1 -> STAT signaling | |
| PDGFR -> STAT signaling | |
| CSF1R -> STAT signaling | |
| KIT -> STAT signaling | |
| HGFR -> STAT signaling | |
| IGF1R -> STAT signaling | |
| InsulinR -> STAT signaling | |
| EphrinR -> STAT signaling | |
| IL6R -> STAT signaling | |
| IL12R -> STAT signaling | |
| IL6ST -> STAT5B signaling | |
| IL31R -> STAT signaling | |
| IL3R -> STAT signaling | |
| IL11R -> STAT3 signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL5R -> STAT signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| OncostatinR -> STAT3 signaling | |
| ProlactinR -> STAT signaling | |
| ErythropoietinR -> ELK-SRF/FOS signaling | |
| GHR -> STAT signaling | |
| ErythropoietinR -> NF-kB signaling | |
| LeptinR -> ELK-SRF signaling | |
| CSF3R -> STAT signaling | |
| ThrombopoietinR -> STAT signaling | |
| LIFR -> STAT5A signaling | |
| ErythropoietinR -> STAT signaling | |
| GHR -> ELK-SRF/MYC signaling | |
| CNTFR -> STAT3 signaling | |
| LeptinR -> STAT signaling | |
| CSF2R -> STAT signaling | |
| IFNGR -> STAT signaling | |
| GHR -> NF-kB signaling | |
| CCR2/5 -> STAT signaling | |
| CXCR4 -> STAT signaling | |
| CCR5 -> TP53 signaling | |
| VasopressinR1 -> STAT signaling | |
| PTAFR -> STAT3 signaling | |
| AdrenergicRa -> ELK-SRF signaling | |
| CholecystokininR -> STAT signaling | |
| AdrenergicRa -> STAT1 signaling | |
| SerotoninR2 -> STAT3 signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| AdrenergicRa -> STAT3 signaling | |
| AngiotensinR -> STAT signaling | |
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| VasopressinR2 -> STAT signaling | |
| ThrombinR -> STAT1 signaling | |
| Clozapine-Induced Granulocytopenia | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| ROS in Neutrophil-Mediated Cell Damage | |
| LTA Expression Targets | |
| TNF/STAT Expression Targets | |
| IL12B Expression Targets | |
| IL6 Expression Targets | |
| IL5 Expression Targets | |
| IL11 Expression Targets | |
| IL31 Expression Targets | |
| IL3 Expression Targets | |
| LIF Expression Targets | |
| CTF1 Expression Targets | |
| OSM-IL6ST/LIFR Expression Targets | |
| Thrombopoietin/STAT Expression Targets | |
| Erythropoietin/STAT Expression Targets | |
| Erythropoietin/ELK-SRF Expression Targets | |
| Erythropoietin/NF-kB Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| GH2-GHR Expression Target | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| CSH1-GHR Expression Targets | |
| GH1-PRLR Expression Targets | |
| PRL-PRLR Expression Targets | |
| CSH1-PRLR Expression Targets | |
| CSF3 Expression Targets | |
| CNTF Expression Targets | |
| CLCF1 Expression Targets | |
| IFNG-IFNR Expression Targets | |
| OSM-OSMR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| CCL2 Expression Targets | |
| CCL3 Expression Targets | |
| CCL4 Expression Targets | |
| CCL5 Expression Targets | |
| CCL7 Expression Target | |
| CCL8 Expression Targets | |
| CCL11 Expression Targets | |
| CCL16 Expression Targets | |
| CCL3L1 Expression Target | |
| IL8 Expression Targets | |
| CXCL12 Expression Targets | |
| AREG/STAT Expression Targets | |
| BTC/STAT Expression Targets | |
| EREG/STAT Expression Targets | |
| HBEGF/STAT Expression Targets | |
| NRG1/STAT Expression Targets | |
| TGFA/STAT Expression Targets | |
| FGF1/STAT Expression Targets | |
| FGF10/STAT Expression Targets | |
| FGF18/STAT Expression Targets | |
| CSF1/STAT Expression Targets | |
| KITLG/STAT Expression Targets | |
| PDGFB/STAT Expression Target | |
| PDGFC/STAT Expression Target | |
| PDGFD/STAT Expression Targets | |
| EFNA1/STAT Expression Target | |
| IGF2/STAT Expression Targets | |
| Erythropoietin/AP-1/MYC/CREB Expression Targets | |
| Erythropoietin/FOXO3A Expression Targets | |
| EphrinR Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| Serotonin/Gq Expression Targets | |
| Epinephrine/Gq Expression Targets | |
| AVP/Gq -> STAT Expression Targets | |
| CCK Expression Targets | |
| Morphine Expression Targets | |
| GAST Expression Targets | |
| AVP/Gs -> STAT Expression Targets | |
| Noreadrenaline/Gq Expression Targets | |
| POMC Expression Targets | |
| IFNA1/Gq Expression Targets | |
| CD80/STAT Expression Targets | |
| CD86/STAT Expression Targets | |
| CD22/STAT Expression Targets | |
| CD72/STAT Expression Target | |
| PDCD1/STAT Expression Targets | |
| AGT/TP53 Expression Targets | |
| AGT/ELK-SRF Expression Targets | |
| HGF/STAT Expression Targets | |
| IGF1/STAT Expression Targets | |
| Insulin/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/STAT Expression Targets | |
| PDGF/STAT Expression Targets | |
| FGF8/STAT Expression Targets | |
| FGF9/STAT Expression Targets | |
| angiotensin II signaling pathway via AT1 receptor | |
| leptin system pathway | |
| leptin system pathway | |
| angiotensin II signaling pathway via AT1 receptor |
| Group | JAK |
|---|---|
| cellular component movement | |
| regulation of interferon-gamma-mediated signaling pathway | |
| positive regulation of phosphatidylinositol 3-kinase cascade | |
| positive regulation of growth hormone receptor signaling pathway | |
| positive regulation of tyrosine phosphorylation of Stat5 protein | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| activation of MAPKK activity | |
| activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | |
| positive regulation of insulin secretion | |
| signal transduction | |
| intracellular signal transduction | |
| hormone-mediated signaling pathway | |
| mineralocorticoid receptor signaling pathway | |
| intracellular protein kinase cascade | |
| JAK-STAT cascade | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| intrinsic apoptotic signaling pathway in response to oxidative stress | |
| cytokine-mediated signaling pathway | |
| G-protein coupled receptor signaling pathway | |
| enzyme linked receptor protein signaling pathway | |
| tumor necrosis factor-mediated signaling pathway | |
| interferon-gamma-mediated signaling pathway | |
| interleukin-12-mediated signaling pathway | |
| platelet-derived growth factor receptor signaling pathway | |
| growth hormone receptor signaling pathway | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| activation of JAK2 kinase activity | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of phosphoprotein phosphatase activity | |
| negative regulation of cell proliferation | |
| negative regulation of cell-cell adhesion | |
| negative regulation of neuron apoptotic process | |
| positive regulation of cell activation | |
| positive regulation of cell differentiation | |
| positive regulation of cell proliferation | |
| positive regulation of cell migration | |
| positive regulation of cell-substrate adhesion | |
| positive regulation of apoptotic process | |
| positive regulation of protein import into nucleus, translocation | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| cell differentiation | |
| axon regeneration | |
| myeloid cell differentiation | |
| erythrocyte differentiation | |
| protein phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| protein autophosphorylation | |
| tyrosine phosphorylation of STAT protein | |
| tyrosine phosphorylation of Stat3 protein | |
| tyrosine phosphorylation of Stat5 protein | |
| tyrosine phosphorylation of Stat1 protein | |
| histone H3-Y41 phosphorylation | |
| phosphorylation | |
| STAT protein import into nucleus | |
| elevation of cytosolic calcium ion concentration | |
| apoptotic process | |
| actin filament polymerization | |
| chromatin modification | |
| innate immune response | |
| response to hydroperoxide | |
| response to lipopolysaccharide | |
| response to interleukin-12 | |
| response to granulocyte macrophage colony-stimulating factor stimulus | |
| response to tumor necrosis factor | |
| response to antibiotic | |
| response to oxidative stress | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| negative regulation of heart contraction | |
| positive regulation of tumor necrosis factor production | |
| positive regulation of interleukin-1 beta production | |
| positive regulation of nitric-oxide synthase biosynthetic process | |
| mesoderm development | |
| mammary gland epithelium development | |
| blood coagulation | |
| negative regulation of DNA binding | |
| positive regulation of DNA binding | |
| receptor binding | |
| phosphatidylinositol 3-kinase binding | |
| protein C-terminus binding | |
| insulin receptor substrate binding | |
| histone binding | |
| acetylcholine receptor binding | |
| interleukin-12 receptor binding | |
| growth hormone receptor binding | |
| type 1 angiotensin receptor binding | |
| peptide hormone receptor binding | |
| protein kinase binding | |
| SH2 domain binding | |
| nucleotide binding | |
| ATP binding | |
| heme binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity | |
| histone kinase activity (H3-Y41 specific) | |
| membrane | |
| nuclear matrix | |
| endosome lumen | |
| membrane raft | |
| caveola | |
| endomembrane system | |
| cytoplasm | |
| cytosol | |
| cytoskeleton | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| MedScan ID | 3717 |
|---|
| Hugo ID | 6192 |
|---|
| Human chromosome position | 9p24 |
|---|
| LocusLink ID | 3717 |
|---|---|
| 16452 | |
| 24514 | |
| 98155 | |
| 107213 | |
| 525246 | |
| 30307 |
| Alias | JTK10 |
|---|---|
| THCYT3 | |
| tyrosine-protein kinase JAK2 | |
| JAK-2 | |
| Janus kinase 2 (a protein tyrosine kinase) | |
| Fd17 | |
| C81284 | |
| AI504024 | |
| JAK2 kinase | |
| Janus kinase II | |
| OTTHUMP00000043260 | |
| OTTHUMP00000021024 | |
| Janus kinase 2 | |
| Jak2 | |
| C81284s | |
| expressed sequence AI504024 | |
| expressed sequence C81284 | |
| Jak2a kinase | |
| Janus kinase 2a | |
| TEL/JAK2 fusion protein | |
| chromosome | |
| jak2a | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 147796 |
|---|---|
| 601626 | |
| 600880 | |
| 187950 | |
| 254450 | |
| 263300 | |
| 614521 |
| Unigene ID | Hs.656213 |
|---|---|
| Mm.275839 | |
| Rn.18909 | |
| Hs.591081 | |
| Mm.393199 | |
| Hs.434374 | |
| Bt.25287 | |
| Dr.4151 |
| KEGG ID | hsa:3717 |
|---|---|
| mmu:16452 | |
| rno:24514 |
| Swiss-Prot Accession | O60674 |
|---|---|
| G5E852 | |
| Q62120 | |
| Q62689 | |
| Q62124 | |
| Q7TQD0 | |
| O14636 | |
| O75297 | |
| Q506Q0 | |
| Q52R86 | |
| Q8IXP2 | |
| Q8CIN8 | |
| O35804 |
| EC Number | 2.7.10.2 |
|---|---|
| 2.7.10.1 | |
| 2.7.1.112 |
| GO ID | 0005524 |
|---|---|
| 0042169 | |
| 0033130 | |
| 0005131 | |
| 0020037 | |
| 0042393 | |
| 0035401 | |
| 0043560 | |
| 0005143 | |
| 0004715 | |
| 0051428 | |
| 0043548 | |
| 0004672 | |
| 0019901 | |
| 0004713 | |
| 0005102 | |
| 0007186 | |
| 0007259 | |
| 0060397 | |
| 0007262 | |
| 0030041 | |
| 0042977 | |
| 0000186 | |
| 0006919 | |
| 0097296 | |
| 0006915 | |
| 0031103 | |
| 0007596 | |
| 0030154 | |
| 0006928 | |
| 0019221 | |
| 0007204 | |
| 0007167 | |
| 0030218 | |
| 0060396 | |
| 0035409 | |
| 0009755 | |
| 0060333 | |
| 0035722 | |
| 0007243 | |
| 0035556 | |
| 0008631 | |
| 0061180 | |
| 0007498 | |
| 0031959 | |
| 0043392 | |
| 0008285 | |
| 0022408 | |
| 0045822 | |
| 0018108 | |
| 0048008 | |
| 0043388 | |
| 0043065 | |
| 0050867 | |
| 0045597 | |
| 0030335 | |
| 0008284 | |
| 0010811 | |
| 0060399 | |
| 0050729 | |
| 0032024 | |
| 0032731 | |
| 0045429 | |
| 0051770 | |
| 0050731 | |
| 0014068 | |
| 0032516 | |
| 0033160 | |
| 0051091 | |
| 0032760 | |
| 0042517 | |
| 0042523 | |
| 0046777 | |
| 0006468 | |
| 0050727 | |
| 0060334 | |
| 0046677 | |
| 0033194 | |
| 0070671 | |
| 0032496 | |
| 0034612 | |
| 0007165 | |
| 0033209 | |
| 0007260 | |
| 0042508 | |
| 0042503 | |
| 0005901 | |
| 0005737 | |
| 0005856 | |
| 0005829 | |
| 0012505 | |
| 0031904 | |
| 0045121 | |
| 0016363 | |
| 0005634 | |
| 0016301 | |
| 0000166 | |
| 0008022 | |
| 0016740 | |
| 0016772 | |
| 0031702 | |
| 0016568 | |
| 0045087 | |
| 0030099 | |
| 0043524 | |
| 0016310 | |
| 0097012 | |
| 0006979 | |
| 0042506 | |
| 0016020 | |
| 0004718 | |
| 0023034 | |
| 0043526 | |
| 0005624 | |
| 0005515 | |
| 0007242 | |
| 0004674 | |
| 0000074 | |
| 0043565 | |
| 0045944 | |
| 0046427 |
| PIR ID | A47511 |
|---|---|
| B39577 | |
| JH0114 | |
| JW0091 | |
| JC4127 |
| Swiss-Prot ID | JAK2_MOUSE |
|---|---|
| JAK2_HUMAN | |
| JAK2_RAT |
| Cell Localization | Endomembrane system |
|---|---|
| Cytoplasm | |
| Nucleus |
| IPI ID | IPI00122143 |
|---|---|
| IPI00031016 | |
| IPI00207182 | |
| IPI00885005 | |
| IPI00476692 |
| Mouse chromosome position | 19 24.0 cM |
|---|
| Rat chromosome position | 1q51-q53 |
|---|
| Homologene ID | 21033 |
|---|
| MGI ID | 96629 |
|---|---|
| 2147795 | |
| 2147569 |
| RGD ID | 2939 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 9p24 |
|---|
| Microarray ID | 101457_at |
|---|---|
| 205841_at | |
| 1421065_at |
| FunctionalClass | ATP binding |
|---|---|
| Janus kinase | |
| SH2 domain binding | |
| nucleotide binding | |
| protein-tyrosine kinase | |
| receptor binding | |
| transferase | |
| kinase | |
| protein binding | |
| protein kinase | |
| protein serine/threonine kinase | |
| sequence-specific DNA binding | |
| growth hormone receptor binding |
| Mus musculus Chromosome position | 19 24.0 cM |
|---|---|
| 19 |
| KEGG pathway | Jak-STAT signaling pathway |
|---|---|
| Adipocytokine signaling pathway | |
| Pancreatic cancer |
| Rattus norvegicus Chromosome position | 1q51-q53 |
|---|
| Bos taurus Chromosome position | 8 |
|---|