| URN | urn:agi-llid:183 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4022 |
| Name | Agt |
| Description | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Notes | The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq] |
| Ariadne Ontology | Neuromodulator |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | growth factor activity |
|---|---|
| hormone activity | |
| angiotensin receptor binding | |
| type 1 angiotensin receptor binding | |
| type 2 angiotensin receptor binding | |
| acetyltransferase activator activity | |
| serine-type endopeptidase inhibitor activity | |
| alpha1-adrenergic receptor activity |
| GO Cellular Component | extracellular region |
|---|---|
| cytoplasmic part | |
| extracellular space |
| GO Biological Process | cell-cell signaling |
|---|---|
| regulation of long-term neuronal synaptic plasticity | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| positive regulation of phosphatidylinositol 3-kinase cascade | |
| positive regulation of MAPK cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of activation of JAK2 kinase activity | |
| regulation of cell growth | |
| regulation of cell proliferation | |
| cell surface receptor signaling pathway | |
| ERK1 and ERK2 cascade | |
| stress-activated MAPK cascade | |
| nitric oxide mediated signal transduction | |
| G-protein coupled receptor signaling pathway | |
| phospholipase C-activating G-protein coupled receptor signaling pathway | |
| G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | |
| negative regulation of cell growth | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of cholesterol esterification | |
| positive regulation of reactive oxygen species metabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of fatty acid biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of protein tyrosine kinase activity | |
| positive regulation of superoxide anion generation | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of cell proliferation | |
| negative regulation of neuron apoptotic process | |
| positive regulation of extracellular matrix constituent secretion | |
| positive regulation of fibroblast proliferation | |
| positive regulation of endothelial cell migration | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of apoptotic process | |
| induction of apoptosis | |
| regulation of norepinephrine secretion | |
| regulation of apoptotic process | |
| cell growth involved in cardiac muscle cell development | |
| establishment of blood-nerve barrier | |
| smooth muscle cell differentiation | |
| astrocyte activation | |
| cytokine secretion | |
| cellular lipid metabolic process | |
| cell-matrix adhesion | |
| catenin import into nucleus | |
| cellular sodium ion homeostasis | |
| cellular response to mechanical stimulus | |
| extracellular matrix organization | |
| fibroblast proliferation | |
| smooth muscle cell proliferation | |
| response to cold | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| response to salt stress | |
| drinking behavior | |
| angiotensin-mediated drinking behavior | |
| response to muscle activity involved in regulation of muscle adaptation | |
| negative regulation of tissue remodeling | |
| negative regulation of angiogenesis | |
| positive regulation of multicellular organism growth | |
| positive regulation of organ growth | |
| positive regulation of cytokine production | |
| positive regulation of renal sodium excretion | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| positive regulation of cardiac muscle hypertrophy | |
| regulation of vasoconstriction | |
| regulation of renal sodium excretion | |
| positive regulation of gene expression | |
| regulation of gene expression | |
| regulation of proteolysis | |
| positive regulation of catalytic activity | |
| negative regulation of endopeptidase activity | |
| activation of phospholipase C activity | |
| positive regulation of NAD(P)H oxidase activity | |
| regulation of calcium ion transport | |
| aging | |
| branching involved in ureteric bud morphogenesis | |
| blood vessel development | |
| kidney development | |
| blood vessel remodeling | |
| excretion | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood volume by renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| uterine smooth muscle contraction | |
| artery smooth muscle contraction | |
| peristalsis | |
| vasoconstriction | |
| vasodilation | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| renin-angiotensin regulation of aldosterone production | |
| renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure | |
| low-density lipoprotein particle remodeling | |
| ovarian follicle rupture | |
| hormone metabolic process | |
| small molecule metabolic process | |
| regulation of blood pressure | |
| positive regulation of blood pressure |
| Pathway | AngiotensinR -> STAT signaling |
|---|---|
| AngiotensinR -> CREB/ELK-SRF/TP53 signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| Bextra-Induced Ischemic Disease | |
| ROS and RNS in Regulation of Vasoconstriction and Vasodilation | |
| ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy | |
| ROS in Triggering Vascular Inflammation | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| SST Expression Targets | |
| AGT/TP53 Expression Targets | |
| AGT/ELK-SRF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| renin-angiotensin system signaling pathway | |
| angiotensin II signaling pathway | |
| angiotensin II signaling pathway via AT1 receptor | |
| renin-angiotensin cascade pathway | |
| losartan pharmacodynamics pathway | |
| angiotensin II signaling pathway via AT2 receptor | |
| drug-gene, gene-chemical, gene-gene interaction pathway | |
| losartan_expanded2 | |
| losartan_expanded3 | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| losartan-gene, gene-chemical, gene-gene interaction pathway | |
| angiotensin II signaling pathway via AT1 receptor |
| Group | Neuromodulator |
|---|---|
| cell-cell signaling | |
| regulation of long-term neuronal synaptic plasticity | |
| negative regulation of nerve growth factor receptor signaling pathway | |
| positive regulation of phosphatidylinositol 3-kinase cascade | |
| positive regulation of MAPK cascade | |
| positive regulation of epidermal growth factor receptor signaling pathway | |
| activation of NF-kappaB-inducing kinase activity | |
| positive regulation of activation of JAK2 kinase activity | |
| regulation of cell growth | |
| regulation of cell proliferation | |
| cell surface receptor signaling pathway | |
| ERK1 and ERK2 cascade | |
| stress-activated MAPK cascade | |
| nitric oxide mediated signal transduction | |
| G-protein coupled receptor signaling pathway | |
| phospholipase C-activating G-protein coupled receptor signaling pathway | |
| G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger | |
| negative regulation of cell growth | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of cholesterol esterification | |
| positive regulation of reactive oxygen species metabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of fatty acid biosynthetic process | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of protein tyrosine kinase activity | |
| positive regulation of superoxide anion generation | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of cell proliferation | |
| negative regulation of neuron apoptotic process | |
| positive regulation of extracellular matrix constituent secretion | |
| positive regulation of fibroblast proliferation | |
| positive regulation of endothelial cell migration | |
| positive regulation of macrophage derived foam cell differentiation | |
| positive regulation of apoptotic process | |
| induction of apoptosis | |
| regulation of norepinephrine secretion | |
| regulation of apoptotic process | |
| cell growth involved in cardiac muscle cell development | |
| establishment of blood-nerve barrier | |
| smooth muscle cell differentiation | |
| astrocyte activation | |
| cytokine secretion | |
| cellular lipid metabolic process | |
| cell-matrix adhesion | |
| catenin import into nucleus | |
| cellular sodium ion homeostasis | |
| cellular response to mechanical stimulus | |
| extracellular matrix organization | |
| fibroblast proliferation | |
| smooth muscle cell proliferation | |
| response to cold | |
| positive regulation of inflammatory response | |
| regulation of inflammatory response | |
| response to salt stress | |
| drinking behavior | |
| angiotensin-mediated drinking behavior | |
| response to muscle activity involved in regulation of muscle adaptation | |
| negative regulation of tissue remodeling | |
| negative regulation of angiogenesis | |
| positive regulation of multicellular organism growth | |
| positive regulation of organ growth | |
| positive regulation of cytokine production | |
| positive regulation of renal sodium excretion | |
| positive regulation of branching involved in ureteric bud morphogenesis | |
| positive regulation of cardiac muscle hypertrophy | |
| regulation of vasoconstriction | |
| regulation of renal sodium excretion | |
| positive regulation of gene expression | |
| regulation of gene expression | |
| regulation of proteolysis | |
| positive regulation of catalytic activity | |
| negative regulation of endopeptidase activity | |
| activation of phospholipase C activity | |
| positive regulation of NAD(P)H oxidase activity | |
| regulation of calcium ion transport | |
| aging | |
| branching involved in ureteric bud morphogenesis | |
| blood vessel development | |
| kidney development | |
| blood vessel remodeling | |
| excretion | |
| brain renin-angiotensin system | |
| regulation of systemic arterial blood pressure by circulatory renin-angiotensin | |
| regulation of blood volume by renin-angiotensin | |
| regulation of blood vessel size by renin-angiotensin | |
| regulation of renal output by angiotensin | |
| uterine smooth muscle contraction | |
| artery smooth muscle contraction | |
| peristalsis | |
| vasoconstriction | |
| vasodilation | |
| angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure | |
| renin-angiotensin regulation of aldosterone production | |
| renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure | |
| low-density lipoprotein particle remodeling | |
| ovarian follicle rupture | |
| hormone metabolic process | |
| small molecule metabolic process | |
| regulation of blood pressure | |
| positive regulation of blood pressure | |
| growth factor activity | |
| hormone activity | |
| angiotensin receptor binding | |
| type 1 angiotensin receptor binding | |
| type 2 angiotensin receptor binding | |
| acetyltransferase activator activity | |
| serine-type endopeptidase inhibitor activity | |
| alpha1-adrenergic receptor activity | |
| extracellular region | |
| cytoplasmic part | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 183 |
|---|
| Hugo ID | 333 |
|---|
| Human chromosome position | 1q42.2 |
|---|---|
| 1q42-q43 |
| LocusLink ID | 183 |
|---|---|
| 11606 | |
| 24179 |
| Alias | ANHU |
|---|---|
| SERPINA8 | |
| angiotensinogen | |
| serpin A8 | |
| angiotensin I | |
| angiotensin II | |
| pre-angiotensinogen | |
| alpha-1 antiproteinase, antitrypsin | |
| serine (or cysteine) proteinase inhibitor | |
| AngI | |
| AngII | |
| Aogen | |
| AI265500 | |
| angiotensin ll | |
| Ang | |
| PAT | |
| ANRT | |
| angiotensinogen (PAT) | |
| angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | |
| FLJ92595 | |
| FLJ97926 | |
| Human angiotensin II | |
| MGC105326 | |
| OTTHUMP00000035878 | |
| angiotensinogen (serine (or cysteine) proteinase inhibitor, clade A (alpha- | |
| ANG II | |
| angiotensin | |
| angiotensinogen (serine (or cysteine) protease inhibitor, clade A (alpha- | |
| angiotensin II human | |
| ANG I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 106150 |
|---|---|
| 145500 | |
| 267430 |
| Unigene ID | Hs.19383 |
|---|---|
| Mm.301626 | |
| Rn.6319 |
| KEGG ID | hsa:183 |
|---|---|
| mmu:11606 | |
| rno:24179 |
| Swiss-Prot Accession | B0ZBE2 |
|---|---|
| B2R5S1 | |
| P01019 | |
| Q3UTR7 | |
| P11859 | |
| P01015 | |
| Q16358 | |
| Q16359 | |
| Q96F91 | |
| Q53GY3 | |
| Q53YY1 | |
| Q59EP2 | |
| Q86U78 | |
| Q8VCN0 |
| GO ID | 0010698 |
|---|---|
| 0008083 | |
| 0005179 | |
| 0004867 | |
| 0031702 | |
| 0031703 | |
| 0070371 | |
| 0007186 | |
| 0007199 | |
| 0007250 | |
| 0007202 | |
| 0007568 | |
| 0001998 | |
| 0003051 | |
| 0014824 | |
| 0048143 | |
| 0001568 | |
| 0001974 | |
| 0001658 | |
| 0035411 | |
| 0061049 | |
| 0007267 | |
| 0007160 | |
| 0044255 | |
| 0071260 | |
| 0006883 | |
| 0050663 | |
| 0008065 | |
| 0007588 | |
| 0030198 | |
| 0048144 | |
| 0042445 | |
| 0006917 | |
| 0001822 | |
| 0034374 | |
| 0030308 | |
| 0008285 | |
| 0010951 | |
| 0051387 | |
| 0043524 | |
| 0034104 | |
| 0007263 | |
| 0001543 | |
| 0030432 | |
| 0007200 | |
| 0043410 | |
| 0033864 | |
| 0051092 | |
| 0010535 | |
| 0043065 | |
| 0090190 | |
| 0010613 | |
| 0032270 | |
| 0010873 | |
| 0001819 | |
| 0010595 | |
| 0045742 | |
| 0003331 | |
| 0045723 | |
| 0048146 | |
| 0050729 | |
| 0010744 | |
| 0040018 | |
| 0046622 | |
| 0050731 | |
| 0014068 | |
| 0061098 | |
| 2000379 | |
| 0035815 | |
| 0032930 | |
| 0045893 | |
| 0002034 | |
| 0002016 | |
| 0001558 | |
| 0042127 | |
| 0048169 | |
| 0014061 | |
| 0030162 | |
| 0002019 | |
| 0035813 | |
| 0019229 | |
| 0001999 | |
| 0002018 | |
| 0009409 | |
| 0014873 | |
| 0009651 | |
| 0044281 | |
| 0051145 | |
| 0048659 | |
| 0051403 | |
| 0042311 | |
| 0044444 | |
| 0005576 | |
| 0005615 | |
| 0031701 | |
| 0002035 | |
| 0007166 | |
| 0042756 | |
| 0045777 | |
| 0043085 | |
| 0010628 | |
| 0042981 | |
| 0008217 | |
| 0051924 | |
| 0010468 | |
| 0050727 | |
| 0001991 | |
| 0042310 | |
| 0004937 | |
| 0016525 | |
| 0070471 | |
| 0006800 | |
| 0003078 | |
| 0005625 | |
| 0030147 | |
| 0050880 |
| PIR ID | A35203 |
|---|---|
| A93945 |
| Swiss-Prot ID | ANGT_HUMAN |
|---|---|
| ANGT_RAT | |
| Q3UTR7_MOUSE | |
| B0ZBE2_HUMAN | |
| B2R5S1_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00032220 |
|---|---|
| IPI00209744 | |
| IPI00654069 |
| Mouse chromosome position | 8 68.0 cM |
|---|
| Rat chromosome position | 19q12 |
|---|
| Homologene ID | 14 |
|---|
| MGI ID | 87963 |
|---|
| RGD ID | 2069 |
|---|
| Primary Cell Localization | Extracellular |
|---|