Protein Arap1

URN	urn:agi-llid:23290
Total Entities	0
Connectivity	45
Name	Arap1
Description	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Notes	The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Ariadne Ontology	Biofluids assayable substances

GO Molecular Function	type 1 angiotensin receptor binding
	phospholipid binding
	phosphatidylinositol-3,4,5-trisphosphate binding
	transcription regulatory region DNA binding
	metal ion binding
	zinc ion binding
	GTPase activator activity
	ARF GTPase activator activity
	Rho GTPase activator activity
	sequence-specific DNA binding transcription factor activity

GO Biological Process	actin filament reorganization involved in cell cycle
	regulation of small GTPase mediated signal transduction
	signal transduction
	regulation of cellular component movement
	SMAD protein signal transduction
	small GTPase mediated signal transduction
	transforming growth factor beta receptor signaling pathway
	regulation of ARF GTPase activity
	positive regulation of Cdc42 GTPase activity
	positive regulation of receptor recycling
	positive regulation of transcription, DNA-dependent
	negative regulation of stress fiber assembly
	positive regulation of filopodium assembly
	regulation of cell shape
	SMAD protein import into nucleus

Pathway	angiotensin II signaling pathway via AT1 receptor
	angiotensin II signaling pathway via AT1 receptor

Group	actin filament reorganization involved in cell cycle
	regulation of small GTPase mediated signal transduction
	signal transduction
	regulation of cellular component movement
	SMAD protein signal transduction
	small GTPase mediated signal transduction
	transforming growth factor beta receptor signaling pathway
	regulation of ARF GTPase activity
	positive regulation of Cdc42 GTPase activity
	positive regulation of receptor recycling
	positive regulation of transcription, DNA-dependent
	negative regulation of stress fiber assembly
	positive regulation of filopodium assembly
	regulation of cell shape
	SMAD protein import into nucleus
	type 1 angiotensin receptor binding
	phospholipid binding
	phosphatidylinositol-3,4,5-trisphosphate binding
	transcription regulatory region DNA binding
	metal ion binding
	zinc ion binding
	GTPase activator activity
	ARF GTPase activator activity
	Rho GTPase activator activity
	sequence-specific DNA binding transcription factor activity
	membrane
	Golgi cisterna membrane
	plasma membrane
	intracellular
	cytoplasm
	cytoplasmic vesicle
	cytosol
	Golgi apparatus
	trans-Golgi network
	Biofluids assayable substances

MedScan ID	23290

Hugo ID	16925

Human chromosome position	11q13.4

Alias	CENTD2
	arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
	cnt-d2
	centaurin-delta-2
	centaurin, delta 2
	ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1
	mKIAA0782
	2410002L19Rik
	KIAA0782
	OTTHUMP00000211459
	OTTHUMP00000211461
	OTTHUMP00000211462
	OTTMUSP00000031901
	OTTMUSP00000031903
	OTTMUSP00000031904
	OTTMUSP00000031902
	ARAP I
	MGC176140
	centaurin, delta II
	ARAP1
	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
	centaurin delta 2 isoform a
	centaurin delta 2 isoform b
	2410002L19

OMIM ID	606646

PIR ID	C59431

Mouse chromosome position	7

Rat chromosome position	1q32

Homologene ID	12326

MGI ID	1916960

RGD ID	1310385