Elsevier Inc. Ca2+ calcium/calcium-mediated signaling pathway protein kinase C (PKC) signaling pathway --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway protein kinase C (PKC) signaling pathway IP3 DAG Gna11 Gnaq G protein mediated signaling pathway via Galphaq family epidermal growth factor/neuregulin signaling pathway EGF transactivation Jak2 the extracellular signal-regulated Raf/Mek/Erk signaling pathway receptor internalization calcium transport pathway renin-angiotensin system signaling pathway Jak-Stat signaling pathway receptor recycling Agtr1 ---- Arrb2 Agtr1 ---- Gnaq Agtr1 ---- Gna11 Agtr1 ---- Jak2 Agtr1b ---- Gnaq Agtr1 ---- Agtrap Agtr1 ---- Arrb1 Agtr1 ---- Arap1 GRK members ---> Agtr1 Agt Agt ---> AgtII AgtII ---- Agtr1 Agtr1b AgtII ---- Agtr1b Agtr1b ---- Gna11 GRK members Arap1 Agtrap ---| Agtr1 Agtr1 Arap1 --+> Agtr1 Rgs2 ---| Gna11 Rgs2 ---| Gnaq Gnaq --+> DAG DAG --+> protein kinase C (PKC) signaling pathway protein kinase C (PKC) signaling pathway ---> epidermal growth factor/neuregulin signaling pathway Rgs2 Arrb2 Arrb1 Agtrap Gnaq --+> IP3 Ca2+ --+> protein kinase C (PKC) signaling pathway IP3 --+> Ca2+ AgtII ---> vasoconstriction vasoconstriction hormone release cell proliferation AgtII ---> cell proliferation AgtII kidney function AgtII ---> kidney function AgtII ---> hormone release