| URN | urn:agi-llid:2161 |
|---|---|
| Total Entities | 0 |
| Connectivity | 458 |
| Name | F12 |
| Description | coagulation factor XII (Hageman factor) |
| Notes | This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| serine-type aminopeptidase activity | |
| misfolded protein binding |
| GO Cellular Component | extracellular region |
|---|---|
| plasma membrane | |
| extracellular space |
| GO Biological Process | innate immune response |
|---|---|
| blood coagulation, intrinsic pathway | |
| plasma kallikrein-kinin cascade | |
| Factor XII activation | |
| positive regulation of blood coagulation | |
| fibrinolysis | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| response to misfolded protein | |
| positive regulation of plasminogen activation | |
| protein processing | |
| zymogen activation | |
| protein autoprocessing | |
| proteolysis |
| Pathway | Coagulation Cascade |
|---|---|
| kallikrein-kinin cascade pathway | |
| coagulation cascade pathway | |
| kallikrein-kinin cascade pathway |
| Group | Coagulation factor |
|---|---|
| innate immune response | |
| blood coagulation, intrinsic pathway | |
| plasma kallikrein-kinin cascade | |
| Factor XII activation | |
| positive regulation of blood coagulation | |
| fibrinolysis | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| response to misfolded protein | |
| positive regulation of plasminogen activation | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| serine-type aminopeptidase activity | |
| protein processing | |
| zymogen activation | |
| protein autoprocessing | |
| proteolysis | |
| misfolded protein binding | |
| extracellular region | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2161 |
|---|---|
| 58992 | |
| 306761 |
| Cell Localization | Extracellular |
|---|---|
| Secreted |
| GO ID | 0051787 |
|---|---|
| 0070009 | |
| 0004252 | |
| 0002542 | |
| 0007596 | |
| 0007597 | |
| 0042730 | |
| 0045087 | |
| 0002353 | |
| 0030194 | |
| 0051919 | |
| 0010756 | |
| 0016540 | |
| 0016485 | |
| 0006508 | |
| 0051788 | |
| 0031638 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0030193 | |
| 0008152 | |
| 0051605 |
| Alias | HAF |
|---|---|
| HAE3 | |
| HAEX | |
| coagulation factor XII | |
| Hageman factor | |
| beta-factor XIIa part 1 | |
| beta-factor XIIa part 2 | |
| coagulation factor XIIa heavy chain | |
| coagulation factor XIIa light chain | |
| FXII | |
| factor XII | |
| coagulation factor XII (Hageman factor) | |
| factor XIIa | |
| F12 gene | |
| coagulating factor xiias | |
| coagulation factor XIIa | |
| Hageman factor beta-fragment | |
| Hageman factor fragment HFf | |
| Human contact activation proteases factor XIIa | |
| Human contact activation proteinases factor XIIa | |
| kallikreinogen activator | |
| kallikreinogen activators | |
| prealbumin activators | |
| prekallikrein activator | |
| blood coagulation factor 12 | |
| prekallikrein activators | |
| blood coagulation hageman factor | |
| coagulating factor XIIa | |
| prealbumin activator | |
| blood clotting factor XII | |
| coagulating factor XII (Hageman factor) | |
| blood clotting factor 12 | |
| clotting factor 12 | |
| thrombocyte factor xii | |
| activated beta blood-coagulating factor 12 | |
| activated beta blood-coagulating factor XII | |
| activated beta blood-coagulating factor xiis | |
| activated beta blood-coagulation factor XII | |
| Angioneurotic edema, hereditary, with normal C1-inhibitor concentration and function | |
| blood coagulating factor 12 | |
| blood-coagulation factor XIIabeta | |
| clotting factor xii | |
| blood coagulating factor XII | |
| blood-coagulation factor XIIf | |
| blood-coagulating factor xiifs | |
| blood-coagulating factor XIIf | |
| blood-coagulating factor xiiabetas | |
| blood coagulation factor XIIs | |
| blood coagulation factor XII activity | |
| blood coagulation factor XII | |
| blood coagulating factor XIIs | |
| blood-coagulating factor XIIabeta | |
| blood coagulating factor xii activities | |
| blood coagulating factor XII activity |
| Mouse chromosome position | 13 |
|---|
| OMIM ID | 610619 |
|---|---|
| 234000 | |
| 610618 |
| Rat chromosome position | 17p14 |
|---|
| Hugo ID | 3530 |
|---|
| Human chromosome position | 5q35.3 |
|---|---|
| 5q33-qter |
| Swiss-Prot Accession | P00748 |
|---|---|
| Q8IZZ5 | |
| Q80YC5 | |
| D3ZTE0 | |
| O35727 | |
| Q6PER0 | |
| P78339 | |
| Q5M879 | |
| P78340 | |
| P78341 | |
| P78342 | |
| P78343 | |
| Q1JR85 | |
| Q96EF3 |
| PIR ID | A29411 |
|---|
| Unigene ID | Hs.1321 |
|---|---|
| Mm.42224 | |
| Rn.53943 |
| KEGG ID | hsa:2161 |
|---|---|
| mmu:58992 | |
| rno:306761 |
| Swiss-Prot ID | FA12_MOUSE |
|---|---|
| FA12_HUMAN | |
| FA12_RAT | |
| Q6PER0_MOUSE | |
| Q5M879_RAT | |
| Q8IZZ5_HUMAN | |
| O35727_MOUSE |
| EC Number | 3.4.21.38 |
|---|
| Ensembl ID | ENSG00000131187 |
|---|---|
| ENSP00000253496 | |
| ENST00000253496 | |
| ENSMUSG00000021492 | |
| ENSMUSP00000021948 | |
| ENSMUST00000021948 | |
| ENSRNOG00000015139 | |
| ENSRNOP00000061983 | |
| ENSRNOT00000066586 |
| Homologene ID | 425 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1891012 |
|---|
| RGD ID | 1359175 |
|---|
| MedScan ID | 2161 |
|---|
| Primary Cell Localization | Extracellular |
|---|
| IPI ID | IPI00951442 |
|---|---|
| IPI00330843 | |
| IPI00019581 | |
| IPI00365752 | |
| IPI00815953 | |
| IPI00815871 | |
| IPI00816036 | |
| IPI00815965 |