| URN | urn:agi-llid:3818 |
|---|---|
| Total Entities | 0 |
| Connectivity | 358 |
| Name | Klkb1 |
| Description | kallikrein B, plasma (Fletcher factor) 1 |
| Notes | Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| plasma membrane | |
| extracellular space |
| GO Biological Process | extracellular matrix disassembly |
|---|---|
| extracellular matrix organization | |
| inflammatory response | |
| Factor XII activation | |
| positive regulation of fibrinolysis | |
| fibrinolysis | |
| blood coagulation, intrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| proteolysis | |
| zymogen activation | |
| plasminogen activation |
| Pathway | Coagulation Cascade |
|---|---|
| kallikrein-kinin cascade pathway | |
| kallikrein-kinin cascade pathway |
| Group | extracellular matrix disassembly |
|---|---|
| extracellular matrix organization | |
| inflammatory response | |
| Factor XII activation | |
| positive regulation of fibrinolysis | |
| fibrinolysis | |
| blood coagulation, intrinsic pathway | |
| hemostasis | |
| blood coagulation | |
| proteolysis | |
| zymogen activation | |
| plasminogen activation | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| extracellular region | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3818 |
|---|
| Hugo ID | 6371 |
|---|
| Human chromosome position | 4q35 |
|---|---|
| 4q34-q35 |
| LocusLink ID | 3818 |
|---|---|
| 16621 | |
| 25048 |
| Alias | PPK |
|---|---|
| KLK3 | |
| plasma kallikrein | |
| kininogenin | |
| Fletcher factor | |
| plasma prekallikrein | |
| plasma kallikrein heavy chain | |
| plasma kallikrein light chain | |
| APS | |
| PSA | |
| Kal3 | |
| Kal-3 | |
| kallikrein 3, plasma | |
| antigen, prostate specific | |
| Kalp1 | |
| KALP15 | |
| Pk | |
| panceatic kallikreins | |
| plasma kallikrein B | |
| plasma kallikrein B1 | |
| plasma B kallikrein | |
| prekallikrein | |
| serine protease-like 1 | |
| serine protease-like I | |
| serine proteinase-like 1 | |
| serine proteinase-like I | |
| serum kallikrein | |
| serum kallikreins | |
| panceatic kallikrein | |
| kallikrein B, plasma (Fletcher factor) 1 | |
| MGC108748 | |
| kallikrein B plasma | |
| kallikrein B, plasma (Fletcher factor) I | |
| kallikrein B, plasma 1 | |
| kallikrein I | |
| kallikrein II | |
| Kallikrein, plasma | |
| kallikrein B, plasma I | |
| kallikrein B | |
| Klkb I | |
| Klkb1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 229000 |
|---|---|
| 612423 |
| Unigene ID | Hs.237642 |
|---|---|
| Mm.482691 | |
| Rn.9880 | |
| Mm.36341 |
| KEGG ID | hsa:3818 |
|---|---|
| mmu:16621 | |
| rno:25048 |
| Swiss-Prot Accession | P03952 |
|---|---|
| P26262 | |
| Q5FVS2 | |
| P14272 | |
| Q8R0P5 | |
| A6NH96 | |
| B2R8H9 | |
| Q17RE8 | |
| Q17RE9 | |
| Q4W5C3 |
| EC Number | 3.4.21.34 |
|---|
| GO ID | 0004252 |
|---|---|
| 0002542 | |
| 0007596 | |
| 0007597 | |
| 0022617 | |
| 0030198 | |
| 0042730 | |
| 0031639 | |
| 0051919 | |
| 0006508 | |
| 0031638 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0006954 | |
| 0005737 |
| PIR ID | A36557 |
|---|---|
| A00921 |
| Swiss-Prot ID | KLKB1_MOUSE |
|---|---|
| KLKB1_HUMAN | |
| Q5FVS2_RAT | |
| Q4W5C3_HUMAN | |
| Q8R0P5_MOUSE |
| Cell Localization | Secreted |
|---|
| IPI ID | IPI00113057 |
|---|---|
| IPI00654888 | |
| IPI00882500 | |
| IPI00930810 | |
| IPI00879718 | |
| IPI00879551 | |
| IPI00879984 | |
| IPI00203384 |
| Mouse chromosome position | 8 26.0 cM |
|---|
| Rat chromosome position | 16q11 |
|---|
| Homologene ID | 68097 |
|---|
| MGI ID | 102849 |
|---|
| RGD ID | 67382 |
|---|