| URN | urn:agi-llid:2161 |
|---|---|
| Total Entities | 0 |
| Connectivity | 326 |
| Name | F12 |
| Description | coagulation factor XII (Hageman factor) |
| Notes | This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq] |
| Ariadne Ontology | Coagulation factor |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | catalytic activity |
|---|---|
| misfolded protein binding | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| serine-type aminopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| plasma membrane | |
| extracellular space |
| GO Biological Process | metabolic process |
|---|---|
| innate immune response | |
| response to misfolded protein | |
| plasma kallikrein-kinin cascade | |
| Factor XII activation | |
| regulation of blood coagulation | |
| positive regulation of blood coagulation | |
| positive regulation of fibrinolysis | |
| fibrinolysis | |
| blood coagulation, intrinsic pathway | |
| positive regulation of plasminogen activation | |
| hemostasis | |
| blood coagulation | |
| proteolysis | |
| protein processing | |
| zymogen activation | |
| protein autoprocessing |
| Pathway | Coagulation Cascade |
|---|---|
| kallikrein-kinin cascade pathway | |
| kallikrein-kinin cascade pathway |
| Group | Coagulation factor |
|---|---|
| metabolic process | |
| innate immune response | |
| response to misfolded protein | |
| plasma kallikrein-kinin cascade | |
| Factor XII activation | |
| regulation of blood coagulation | |
| positive regulation of blood coagulation | |
| positive regulation of fibrinolysis | |
| fibrinolysis | |
| blood coagulation, intrinsic pathway | |
| positive regulation of plasminogen activation | |
| hemostasis | |
| blood coagulation | |
| proteolysis | |
| protein processing | |
| zymogen activation | |
| protein autoprocessing | |
| catalytic activity | |
| misfolded protein binding | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| serine-type aminopeptidase activity | |
| extracellular region | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 2161 |
|---|
| Hugo ID | 3530 |
|---|
| Human chromosome position | 5q33-qter |
|---|
| LocusLink ID | 2161 |
|---|---|
| 58992 | |
| 306761 |
| Alias | HAF |
|---|---|
| HAE3 | |
| HAEX | |
| coagulation factor XII | |
| Hageman factor | |
| beta-factor XIIa part 1 | |
| beta-factor XIIa part 2 | |
| coagulation factor XIIa heavy chain | |
| coagulation factor XIIa light chain | |
| FXII | |
| factor XII | |
| factor XIIa | |
| F12 gene | |
| blood-coagulating factor XIIf | |
| coagulation factor XII (Hageman factor) | |
| kallikreinogen activator | |
| coagulation factor XIIa | |
| Hageman factor beta-fragment | |
| Hageman factor fragment HFf | |
| Human contact activation proteinases factor XIIa | |
| kallikreinogen activators | |
| prealbumin activator | |
| prealbumin activators | |
| prekallikrein activator | |
| prekallikrein activators | |
| Human contact activation proteases factor XIIa | |
| activated beta blood-coagulating factor XII | |
| coagulating factor xiias | |
| activated beta blood-coagulating factor 12 | |
| activated beta blood-coagulating factor xiis | |
| activated beta blood-coagulation factor XII | |
| Angioneurotic edema, hereditary, with normal C1-inhibitor concentration and function | |
| blood coagulating factor 12 | |
| blood coagulating factor XII | |
| blood coagulating factor xii activities | |
| coagulating factor XII (Hageman factor) | |
| blood-coagulation factor XIIabeta | |
| blood coagulating factor XII activity | |
| coagulating factor XIIa | |
| blood-coagulation factor XIIf | |
| blood-coagulating factor xiifs | |
| blood coagulation factor XII | |
| blood-coagulating factor XIIabeta | |
| blood coagulation factor XIIs | |
| blood coagulation factor XII activity | |
| blood-coagulating factor xiiabetas | |
| blood coagulating factor XIIs |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 610619 |
|---|---|
| 234000 | |
| 610618 |
| Unigene ID | Hs.1321 |
|---|---|
| Mm.42224 | |
| Rn.53943 |
| KEGG ID | hsa:2161 |
|---|---|
| mmu:58992 | |
| rno:306761 |
| Swiss-Prot Accession | P00748 |
|---|---|
| Q8IZZ5 | |
| Q80YC5 | |
| D3ZTE0 | |
| Q5M879 | |
| O35727 | |
| Q6PER0 | |
| P78339 | |
| P78340 | |
| P78341 | |
| P78342 | |
| P78343 | |
| Q1JR85 | |
| Q96EF3 |
| EC Number | 3.4.21.38 |
|---|
| GO ID | 0051787 |
|---|---|
| 0004252 | |
| 0002542 | |
| 0007596 | |
| 0007597 | |
| 0042730 | |
| 0045087 | |
| 0002353 | |
| 0030194 | |
| 0051919 | |
| 0010756 | |
| 0016540 | |
| 0016485 | |
| 0006508 | |
| 0051788 | |
| 0031638 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0070009 | |
| 0008236 | |
| 0007599 | |
| 0008152 | |
| 0030193 | |
| 0051605 |
| PIR ID | A29411 |
|---|
| Swiss-Prot ID | FA12_RAT |
|---|---|
| FA12_MOUSE | |
| FA12_HUMAN | |
| Q6PER0_MOUSE | |
| Q5M879_RAT | |
| Q8IZZ5_HUMAN | |
| O35727_MOUSE |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00951442 |
|---|---|
| IPI00330843 | |
| IPI00019581 | |
| IPI00365752 | |
| IPI00815953 | |
| IPI00815871 | |
| IPI00816036 | |
| IPI00815965 |
| Mouse chromosome position | 13 |
|---|
| Rat chromosome position | 17p14 |
|---|
| Homologene ID | 425 |
|---|
| MGI ID | 1891012 |
|---|
| RGD ID | 1359175 |
|---|
| Primary Cell Localization | Extracellular |
|---|