| URN | urn:agi-llid:3816 |
|---|---|
| Total Entities | 0 |
| Connectivity | 389 |
| Name | Klk1 |
| Description | kallikrein 1 |
| Notes | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | metal ion binding |
|---|---|
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | apical part of cell |
|---|---|
| acrosomal vesicle | |
| nucleus |
| GO Biological Process | positive regulation of cell proliferation |
|---|---|
| positive regulation of apoptotic process | |
| response to nutrient | |
| positive regulation of acute inflammatory response | |
| positive regulation of vasoconstriction | |
| proteolysis |
| Pathway | kallikrein-kinin cascade pathway |
|---|---|
| kallikrein-kinin cascade pathway |
| Group | positive regulation of cell proliferation |
|---|---|
| positive regulation of apoptotic process | |
| response to nutrient | |
| positive regulation of acute inflammatory response | |
| positive regulation of vasoconstriction | |
| proteolysis | |
| metal ion binding | |
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| apical part of cell | |
| acrosomal vesicle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3816 |
|---|---|
| 292872 | |
| 650746 | |
| 653879 |
| Hugo ID | 6357 |
|---|
| Human chromosome position | 19q13.3 |
|---|
| LocusLink ID | 3816 |
|---|---|
| 24523 | |
| 24594 | |
| 24841 | |
| 292855 | |
| 292858 | |
| 292866 | |
| 292868 | |
| 292872 | |
| 408242 | |
| 100361452 | |
| 100364577 |
| Alias | hK1 |
|---|---|
| KLKR | |
| Klk6 | |
| kallikrein-1 | |
| tissue kallikrein | |
| glandular kallikrein 1 | |
| kallikrein serine protease 1 | |
| kallikrein 1, renal/pancreas/salivary | |
| kidney/pancreas/salivary gland kallikrein | |
| Kal | |
| KALA | |
| Klk1 | |
| Klk5 | |
| Klk7 | |
| Klk1l | |
| RGK-7 | |
| RSKG-7 | |
| RATKALA | |
| glandular kallikrein-7, submandibular/renal | |
| esterase B | |
| kallikrein 5 | |
| kallikrein 7 | |
| proteinase A | |
| renal kallikrein | |
| kallikrein 1-like peptidase | |
| kallikrein-related protein K1 | |
| Kallikrein 1 renal/pancreas/salivary | |
| Ngfg | |
| rK-1 | |
| rGK-1 | |
| Klk1b3 | |
| Klk1c1 | |
| gamma-NGF | |
| PS kallikrein | |
| pancreatic kallikrein | |
| true tissue kallikrein | |
| nerve growth factor gamma chain | |
| kallikrein 1-related peptidase b3 | |
| nerve growth factor gamma polypeptide | |
| Ton | |
| KLK2 | |
| rGK-2 | |
| tonin | |
| RSKG-5 | |
| esterase 1 | |
| S2 kallikrein | |
| glandular kallikrein-2 | |
| Klk12 | |
| RSKG-3 | |
| glandular kallikrein-12, submandibular/renal | |
| kallikrein 1 | |
| Klk10 | |
| rGK-10 | |
| glandular kallikrein-10 | |
| K10 | |
| T-kininogenase | |
| endopeptidase K | |
| proteinase B antigen | |
| rk8 | |
| KLK8 | |
| rGK-8 | |
| Klk1b21 | |
| prostatic glandular kallikrein-6 | |
| kallikrein 6 | |
| P1 Kallikrein | |
| serine protease | |
| glandular kallikrein-8 | |
| kallikrein 1-related peptidase b21 | |
| rK9 | |
| Klk9 | |
| Klks3 | |
| rGK-9 | |
| submandibular glandular kallikrein-9 | |
| SEV | |
| KLK-S3 | |
| S3 kallikrein | |
| submaxillary gland S3 kallikrein | |
| kallikrein, submaxillary gland S3 | |
| submandibular enzymatic vasoconstrictor | |
| KLK3 | |
| rGK-3 | |
| RSGK-50 | |
| RSKG-50 | |
| Klk1c10l2 | |
| glandular kallikrein-3, submandibular | |
| kallikrein 3 | |
| S1 kallikrein | |
| submaxillary gland S1 kallikrein | |
| kallikrein 1-related peptidase c10-like 2 | |
| Gk6 | |
| Gk11 | |
| rGK-6 | |
| kallikrein 1-related peptidase C6 | |
| glandular kallikrein 11 | |
| glandular kallikrein Klk1c6 | |
| kallikrein 1-related peptidase C4 | |
| Klk-7 | |
| Klk-12 | |
| LOC92787 | |
| mGK I | |
| mGK-1 | |
| RATKALAs | |
| renal/pancreas/salivary kallikrein | |
| LOC126116 | |
| submaxillary gland s3 | |
| true kallikrein | |
| kallikrein serine proteinase 1 | |
| hKLK1 | |
| kallikrein precursor RSKG3 | |
| LOC292868 | |
| kallikrein serine protease I | |
| Glandular kallikrein I | |
| kallikrein serine proteinase I | |
| Kallikrein, renal/pancreas/salivary | |
| KLK I | |
| Klk1c2 | |
| klk1c9 | |
| LOC100361452 | |
| LOC100364577 | |
| Klk1c7 | |
| preprokallikrein | |
| nerve growth factor, gamma | |
| Klk1c12 | |
| glandular kallikrein 12, submandibular/renal | |
| Klk1c8 | |
| Klk1c6 | |
| Klk-10 | |
| rGk11 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| OMIM ID | 147910 |
|---|
| Unigene ID | Hs.123107 |
|---|---|
| Rn.207160 | |
| Rn.11331 | |
| Rn.9882 | |
| Rn.141980 | |
| Rn.220730 | |
| Rn.79264 | |
| Rn.224461 | |
| Rn.107068 | |
| Rn.141979 | |
| Rn.21391 |
| KEGG ID | hsa:3816 |
|---|---|
| rno:24523 | |
| rno:24594 | |
| rno:24841 | |
| rno:292855 | |
| rno:292858 | |
| rno:292866 | |
| rno:292868 | |
| rno:292872 | |
| rno:408242 | |
| rno:100361452 |
| Swiss-Prot Accession | P06870 |
|---|---|
| P36373 | |
| P00758 | |
| P00759 | |
| P36376 | |
| P36375 | |
| P36374 | |
| P07647 | |
| P15950 | |
| Q6IE61 | |
| E9PSK4 | |
| Q66US9 | |
| Q86U61 | |
| Q8TCV8 | |
| Q9BS53 | |
| Q9NQU4 | |
| Q9UD19 | |
| Q9UMJ1 | |
| Q68G17 | |
| Q07277 | |
| Q6T776 | |
| Q9UE84 | |
| Q63274 |
| EC Number | 3.4.21.35 |
|---|
| GO ID | 0004252 |
|---|---|
| 0006508 | |
| 0005634 | |
| 0046872 | |
| 0008236 | |
| 0004175 | |
| 0002675 | |
| 0043065 | |
| 0008284 | |
| 0007584 | |
| 0001669 | |
| 0045177 | |
| 0045907 | |
| 0008233 | |
| 0008270 |
| PIR ID | A34079 |
|---|---|
| A31136 | |
| B31136 | |
| A24696 | |
| B24696 | |
| D23863 | |
| B33359 | |
| A00944 | |
| A44284 | |
| B35545 |
| Swiss-Prot ID | KLK6_RAT |
|---|---|
| KLK7_RAT | |
| KLK12_RAT | |
| KLK1_HUMAN | |
| KLK9_RAT | |
| KLK2_RAT | |
| KLK1_RAT | |
| KLK10_RAT | |
| Q6IE61_RAT | |
| K1KB3_MOUSE | |
| A2RTW1_MOUSE |
| IPI ID | IPI00201593 |
|---|---|
| IPI00201592 | |
| IPI00201595 | |
| IPI00304808 | |
| IPI00930404 | |
| IPI00209517 | |
| IPI00212752 | |
| IPI00231193 | |
| IPI00886439 | |
| IPI00421761 | |
| IPI00134582 | |
| IPI00192928 |
| Rat chromosome position | 1q22 |
|---|---|
| 1 |
| RGD ID | 2969 |
|---|---|
| 3175 | |
| 3888 | |
| 1303192 | |
| 1561403 | |
| 1305359 | |
| 727805 | |
| 735032 | |
| 1303220 | |
| 2320113 |