| URN | urn:agi-llid:710 |
|---|---|
| Total Entities | 0 |
| Connectivity | 429 |
| Name | Serping1 |
| Description | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| Notes | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | complement binding |
|---|---|
| peptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity |
| GO Cellular Component | extracellular region |
|---|---|
| platelet alpha granule lumen | |
| extracellular space |
| GO Biological Process | platelet activation |
|---|---|
| platelet degranulation | |
| complement activation, classical pathway | |
| negative regulation of complement activation, lectin pathway | |
| innate immune response | |
| fibrinolysis | |
| blood coagulation, intrinsic pathway | |
| regulation of proteolysis | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity | |
| blood circulation | |
| hemostasis | |
| blood coagulation |
| Pathway | kallikrein-kinin cascade pathway |
|---|---|
| kallikrein-kinin cascade pathway |
| Group | platelet activation |
|---|---|
| platelet degranulation | |
| complement activation, classical pathway | |
| negative regulation of complement activation, lectin pathway | |
| innate immune response | |
| fibrinolysis | |
| blood coagulation, intrinsic pathway | |
| regulation of proteolysis | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity | |
| blood circulation | |
| hemostasis | |
| blood coagulation | |
| complement binding | |
| peptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity | |
| extracellular region | |
| platelet alpha granule lumen | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 710 |
|---|
| Hugo ID | 1228 |
|---|
| Human chromosome position | 11q12.1 |
|---|---|
| 11q12-q13.1 |
| LocusLink ID | 710 |
|---|---|
| 12258 | |
| 295703 |
| Alias | C1IN |
|---|---|
| C1NH | |
| HAE1 | |
| HAE2 | |
| C1INH | |
| plasma protease C1 inhibitor | |
| serpin G1 | |
| C1-inhibiting factor | |
| C1 esterase inhibitor | |
| complement component 1 inhibitor | |
| serine/cysteine proteinase inhibitor clade G member 1 | |
| RP23-399J8.3 | |
| C1 Inh | |
| C1 inhibitor | |
| serine (or cysteine) proteinase inhibitor, clade G, member 1 | |
| serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1 | |
| serpin peptidase inhibitor, clade G, member 1 | |
| serine (or cysteine) peptidase inhibitor, clade G, member 1 | |
| serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | |
| serine (or cysteine) protease inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | |
| serine (or cysteine) protease inhibitor, clade G, member 1 | |
| serine (or cysteine) protease inhibitor, clade G, member I | |
| serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member I | |
| Serping I | |
| serine (or cysteine) protease inhibitor, clade G (C1 inhibitor), member I | |
| serine (or cysteine) proteinase inhibitor, clade G, member I | |
| serine (or cysteine)ase inhibitor, clade G, member 1 | |
| serine (or cysteine)ase inhibitor, clade G, member I | |
| serine/cysteine protease inhibitor clade G member 1 | |
| serine (or cysteine) protease inhibitor, clade G (C1 inhibitor), member 1 | |
| serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | |
| MGC72585 | |
| Serping1 | |
| OTTMUSP00000014647 | |
| HAE I | |
| OTTHUMP00000197004 | |
| OTTMUSP00000014648 | |
| Plasma proteinase C1 inhibitor | |
| C1-INHs |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606860 |
|---|---|
| 120790 | |
| 106100 |
| Unigene ID | Hs.384598 |
|---|---|
| Mm.38888 | |
| Rn.100285 |
| KEGG ID | hsa:710 |
|---|---|
| mmu:12258 | |
| rno:295703 |
| Swiss-Prot Accession | E9KL26 |
|---|---|
| P05155 | |
| P97290 | |
| Q6P734 | |
| A2ATR7 | |
| O88330 | |
| Q99M43 | |
| Q9QX09 | |
| A6NMU0 | |
| A8KAI9 | |
| B2R6L5 | |
| Q16304 | |
| Q547W3 | |
| Q59EI5 | |
| Q7Z455 | |
| Q96FE0 | |
| Q9UC49 | |
| Q9UCF9 | |
| Q5UGI5 | |
| Q5UGI6 |
| GO ID | 0004867 |
|---|---|
| 0008015 | |
| 0007596 | |
| 0007597 | |
| 0006958 | |
| 0042730 | |
| 0045087 | |
| 0001869 | |
| 0010951 | |
| 0030168 | |
| 0002576 | |
| 0005576 | |
| 0005615 | |
| 0031093 | |
| 0001848 | |
| 0030414 | |
| 0007599 | |
| 0010466 | |
| 0030162 |
| PIR ID | S15386 |
|---|
| Swiss-Prot ID | IC1_RAT |
|---|---|
| IC1_MOUSE | |
| IC1_HUMAN | |
| A2ATR7_MOUSE |
| Cell Localization | Secreted |
|---|
| IPI ID | IPI00372792 |
|---|---|
| IPI00122977 | |
| IPI00291866 | |
| IPI00881377 | |
| IPI00556459 | |
| IPI00385045 | |
| IPI00479178 | |
| IPI00879931 | |
| IPI00879796 | |
| IPI00877850 | |
| IPI00877698 | |
| IPI00750580 |
| Mouse chromosome position | 2 |
|---|
| Rat chromosome position | 3q24 |
|---|
| Homologene ID | 44 |
|---|
| MGI ID | 894696 |
|---|
| RGD ID | 735225 |
|---|