Protein Kng1

URN	urn:agi-llid:589
Total Entities	0
Connectivity	1969
Name	Kng1
Description	kininogen 1
Notes	This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

Ariadne Ontology	Neuromodulator
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	receptor binding
	protease binding
	heparin binding
	zinc ion binding
	peptidase inhibitor activity
	cysteine-type endopeptidase inhibitor activity

GO Cellular Component	extracellular region
	platelet alpha granule lumen
	plasma membrane
	perikaryon
	intracellular membrane-bounded organelle
	extracellular space

GO Biological Process	positive regulation of MAPK cascade
	negative regulation of MAP kinase activity
	negative regulation of proteolysis
	negative regulation of cell adhesion
	negative regulation of lymphocyte proliferation
	negative regulation of T cell proliferation
	positive regulation of fibroblast proliferation
	positive regulation of endothelial cell proliferation
	positive regulation of apoptotic process
	platelet activation
	platelet degranulation
	elevation of cytosolic calcium ion concentration
	inflammatory response
	negative regulation of blood coagulation
	blood coagulation, intrinsic pathway
	positive regulation of renal sodium excretion
	negative regulation of peptidase activity
	regulation of endopeptidase activity
	smooth muscle contraction
	regulation of blood vessel size
	vasodilation
	positive regulation of urine volume
	hemostasis
	blood coagulation

Pathway	Coagulation Cascade
	kallikrein-kinin cascade pathway
	kallikrein-kinin cascade pathway

Group	Neuromodulator
	positive regulation of MAPK cascade
	negative regulation of MAP kinase activity
	negative regulation of proteolysis
	negative regulation of cell adhesion
	negative regulation of lymphocyte proliferation
	negative regulation of T cell proliferation
	positive regulation of fibroblast proliferation
	positive regulation of endothelial cell proliferation
	positive regulation of apoptotic process
	platelet activation
	platelet degranulation
	elevation of cytosolic calcium ion concentration
	inflammatory response
	negative regulation of blood coagulation
	blood coagulation, intrinsic pathway
	positive regulation of renal sodium excretion
	negative regulation of peptidase activity
	regulation of endopeptidase activity
	smooth muscle contraction
	regulation of blood vessel size
	vasodilation
	positive regulation of urine volume
	hemostasis
	blood coagulation
	receptor binding
	protease binding
	heparin binding
	zinc ion binding
	peptidase inhibitor activity
	cysteine-type endopeptidase inhibitor activity
	extracellular region
	platelet alpha granule lumen
	plasma membrane
	perikaryon
	intracellular membrane-bounded organelle
	extracellular space
	Secreted proteins
	Biofluids assayable substances

MedScan ID	589
	16644

Hugo ID	6383

Human chromosome position	3q27

Alias	BDK
	KNG
	kininogen-1
	HMWK
	bradykinin
	fitzgerald factor
	high molecular weight kininogen
	alpha-2-thiol proteinase inhibitor
	williams-Fitzgerald-Flaujeac factor
	H-kininigen
	L-kininogen
	kininogen 2
	Kininogen-II
	kininogen II
	Kngt I
	MGC123404
	MGC117836
	Kngk
	major acute phase protein
	OTTHUMP00000210109
	Kngt1
	TKG6
	Kngt
	RATKINKG
	RATKINKH
	RATKINT1G
	see also D11Elh1 and D11Mit
	T-kininogen
	T-kininogen 1
	T-kininogen 2
	t-kininogen I
	T-kininogen II
	T-kininogen, see also D11Elh1 and D11Mit8
	KINKH
	RATTKG6
	k-kininogen
	Kng2
	alpha-1 major acute phase protein prepeptide
	alpha-1-MAP
	Alpha-2-thiol protease inhibitor
	kininogen
	KNG1
	Kng_v I
	kininogen 1
	K-kininogen, differential splicing leads to HMW Kngk
	KINT1G
	KINKG
	kininogen I
	Kng_v1
	OTTMUSP00000031626
	MGC93589
	MGC123437
	MGC108747
	major acute phase protein (alpha-1-MAP)
	LMW T-kininogen I
	Kng1l1
	Kng1_v1
	kininogen 1-like 1
	kininogen 1, variant 1
	low molecular weight (LMW) T-kininogen II
	thiostatin

OMIM ID	612358
	228960

Mouse chromosome position	16

Rat chromosome position	11q23

Homologene ID	88343

MGI ID	1097705
	3027157

RGD ID	2980

Primary Cell Localization	Extracellular