| URN | urn:agi-llid:3816 |
|---|---|
| Total Entities | 0 |
| Connectivity | 642 |
| Name | Klk1 |
| Description | kallikrein 1 |
| Notes | Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq] |
| GO Molecular Function | endopeptidase activity |
|---|---|
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| metal ion binding |
| GO Cellular Component | apical part of cell |
|---|---|
| acrosomal vesicle | |
| nucleus |
| GO Biological Process | positive regulation of vasoconstriction |
|---|---|
| positive regulation of apoptotic process | |
| positive regulation of cell proliferation | |
| response to nutrient | |
| positive regulation of acute inflammatory response | |
| proteolysis |
| Pathway | Proteins Involved in Pathogenesis of Myocardial Ischemia |
|---|---|
| kallikrein-kinin cascade pathway | |
| kallikrein-kinin cascade pathway |
| Group | positive regulation of vasoconstriction |
|---|---|
| positive regulation of apoptotic process | |
| positive regulation of cell proliferation | |
| response to nutrient | |
| positive regulation of acute inflammatory response | |
| endopeptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| proteolysis | |
| metal ion binding | |
| apical part of cell | |
| acrosomal vesicle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 3816 |
|---|---|
| 24523 | |
| 24594 | |
| 24841 | |
| 292855 | |
| 292858 | |
| 292866 | |
| 292868 | |
| 292872 | |
| 408242 | |
| 100361452 | |
| 100364577 |
| GO ID | 0004252 |
|---|---|
| 0006508 | |
| 0005634 | |
| 0004175 | |
| 0002675 | |
| 0043065 | |
| 0008284 | |
| 0007584 | |
| 0001669 | |
| 0045177 | |
| 0046872 | |
| 0008236 | |
| 0045907 | |
| 0008233 | |
| 0008270 |
| Alias | hK1 |
|---|---|
| KLKR | |
| Klk6 | |
| kallikrein-1 | |
| tissue kallikrein | |
| glandular kallikrein 1 | |
| kallikrein serine protease 1 | |
| kallikrein 1, renal/pancreas/salivary | |
| kidney/pancreas/salivary gland kallikrein | |
| Kal | |
| KALA | |
| Klk1 | |
| Klk5 | |
| Klk7 | |
| Klk1l | |
| RGK-7 | |
| RSKG-7 | |
| RATKALA | |
| glandular kallikrein-7, submandibular/renal | |
| esterase B | |
| kallikrein 5 | |
| kallikrein 7 | |
| proteinase A | |
| renal kallikrein | |
| kallikrein 1-like peptidase | |
| kallikrein-related protein K1 | |
| Kallikrein 1 renal/pancreas/salivary | |
| Ngfg | |
| rK-1 | |
| rGK-1 | |
| Klk1b3 | |
| Klk1c1 | |
| gamma-NGF | |
| PS kallikrein | |
| pancreatic kallikrein | |
| true tissue kallikrein | |
| nerve growth factor gamma chain | |
| kallikrein 1-related peptidase b3 | |
| nerve growth factor gamma polypeptide | |
| Ton | |
| KLK2 | |
| rGK-2 | |
| tonin | |
| RSKG-5 | |
| esterase 1 | |
| S2 kallikrein | |
| glandular kallikrein-2 | |
| Klk12 | |
| RSKG-3 | |
| glandular kallikrein-12, submandibular/renal | |
| kallikrein 1 | |
| Klk10 | |
| rGK-10 | |
| glandular kallikrein-10 | |
| K10 | |
| T-kininogenase | |
| endopeptidase K | |
| proteinase B antigen | |
| rk8 | |
| KLK8 | |
| rGK-8 | |
| Klk1b21 | |
| prostatic glandular kallikrein-6 | |
| kallikrein 6 | |
| P1 Kallikrein | |
| serine protease | |
| glandular kallikrein-8 | |
| kallikrein 1-related peptidase b21 | |
| rK9 | |
| Klk9 | |
| Klks3 | |
| rGK-9 | |
| submandibular glandular kallikrein-9 | |
| SEV | |
| KLK-S3 | |
| S3 kallikrein | |
| submaxillary gland S3 kallikrein | |
| kallikrein, submaxillary gland S3 | |
| submandibular enzymatic vasoconstrictor | |
| KLK3 | |
| rGK-3 | |
| RSGK-50 | |
| RSKG-50 | |
| Klk1c10l2 | |
| glandular kallikrein-3, submandibular | |
| kallikrein 3 | |
| S1 kallikrein | |
| submaxillary gland S1 kallikrein | |
| kallikrein 1-related peptidase c10-like 2 | |
| Gk6 | |
| Gk11 | |
| rGK-6 | |
| kallikrein 1-related peptidase C6 | |
| glandular kallikrein 11 | |
| glandular kallikrein Klk1c6 | |
| kallikrein 1-related peptidase C4 | |
| Klk-12 | |
| Klk-7 | |
| submaxillary gland s3 | |
| true kallikrein | |
| renal/pancreas/salivary kallikrein | |
| kallikrein 1-related peptidase C9 | |
| kallikrein 1-related peptidase C8 | |
| kallikrein 1-related peptidase C7 | |
| kallikrein 1-related peptidase C10 | |
| kallikrein 1-related peptidase C12 | |
| glandular kallikrein-10-like | |
| LOC100909767 | |
| LOC100364577 | |
| LOC100361452 | |
| kallikrein 1-related peptidase C3 | |
| kallikrein serine proteinase I | |
| kallikrein serine proteinase 1 | |
| kallikrein serine protease I | |
| kallikrein precursor RSKG3 | |
| Kallikrein, renal/pancreas/salivary | |
| RATKALAs | |
| hKLK1 | |
| Glandular kallikrein I | |
| kallikrein 1-related peptidase C2 | |
| mGK-1 | |
| mGK I | |
| LOC92787 | |
| LOC292868 | |
| LOC126116 | |
| KLK I | |
| Klk1c2 | |
| klk1c9 | |
| Klk1c7 | |
| preprokallikrein | |
| nerve growth factor, gamma | |
| Klk1c12 | |
| glandular kallikrein 12, submandibular/renal | |
| Klk1c8 | |
| Klk1c6 | |
| Klk-10 | |
| rGk11 |
| OMIM ID | 147910 |
|---|
| Rat chromosome position | 1q22 |
|---|---|
| 1 |
| Hugo ID | 6357 |
|---|
| Human chromosome position | 19q13.3 |
|---|
| Swiss-Prot Accession | P06870 |
|---|---|
| F8WAM8 | |
| P36373 | |
| P00758 | |
| P00759 | |
| P36376 | |
| P36375 | |
| P36374 | |
| P07647 | |
| P15950 | |
| Q6IE61 | |
| Q66US9 | |
| Q86U61 | |
| Q8TCV8 | |
| Q9BS53 | |
| Q9NQU4 | |
| Q9UD19 | |
| Q9UMJ1 | |
| Q68G17 | |
| E9PSK4 | |
| Q07277 | |
| Q6T776 | |
| Q9UE84 | |
| Q63274 |
| PIR ID | B31136 |
|---|---|
| A34079 | |
| A31136 | |
| A24696 | |
| B24696 | |
| B33359 | |
| D23863 | |
| A00944 | |
| A44284 | |
| B35545 |
| Unigene ID | Hs.123107 |
|---|---|
| Rn.207160 | |
| Rn.11331 | |
| Rn.9882 | |
| Rn.141980 | |
| Rn.220730 | |
| Rn.79264 | |
| Rn.224461 | |
| Rn.107068 | |
| Rn.141979 | |
| Rn.21391 |
| KEGG ID | hsa:3816 |
|---|---|
| rno:24523 | |
| rno:24594 | |
| rno:24841 | |
| rno:292855 | |
| rno:292858 | |
| rno:292866 | |
| rno:292868 | |
| rno:292872 | |
| rno:408242 | |
| rno:100361452 |
| Swiss-Prot ID | KLK12_RAT |
|---|---|
| KLK6_RAT | |
| KLK7_RAT | |
| KLK1_HUMAN | |
| KLK2_RAT | |
| KLK9_RAT | |
| KLK1_RAT | |
| KLK10_RAT | |
| Q6IE61_RAT | |
| K1KB3_MOUSE | |
| A2RTW1_MOUSE |
| EC Number | 3.4.21.35 |
|---|
| Ensembl ID | ENSG00000167748 |
|---|---|
| ENSP00000301420 | |
| ENST00000301420 | |
| ENSP00000400994 | |
| ENST00000448701 | |
| ENSRNOG00000047527 | |
| ENSRNOP00000066004 | |
| ENSRNOT00000071416 | |
| ENSRNOG00000029221 | |
| ENSRNOP00000025831 | |
| ENSRNOT00000025831 | |
| ENSRNOG00000029237 | |
| ENSRNOP00000025701 | |
| ENSRNOT00000025701 | |
| ENSRNOG00000047662 | |
| ENSRNOP00000025631 | |
| ENSRNOT00000025631 | |
| ENSRNOG00000046297 | |
| ENSRNOP00000050040 | |
| ENSRNOT00000045756 | |
| ENSRNOG00000048901 | |
| ENSRNOP00000067862 | |
| ENSRNOT00000072124 | |
| ENSRNOG00000032857 | |
| ENSRNOP00000025723 | |
| ENSRNOT00000025723 | |
| ENSRNOG00000033414 | |
| ENSRNOP00000025777 | |
| ENSRNOT00000025777 | |
| ENSRNOG00000048630 | |
| ENSRNOP00000049589 | |
| ENSRNOT00000046377 |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus |
| RGD ID | 2969 |
|---|---|
| 3175 | |
| 3888 | |
| 1303192 | |
| 1561403 | |
| 1305359 | |
| 727805 | |
| 735032 | |
| 1303220 | |
| 2320113 |
| MedScan ID | 3816 |
|---|---|
| 292872 | |
| 650746 | |
| 653879 |
| IPI ID | IPI00201593 |
|---|---|
| IPI00201592 | |
| IPI00201595 | |
| IPI00304808 | |
| IPI00930404 | |
| IPI00209517 | |
| IPI00212752 | |
| IPI00231193 | |
| IPI00886439 | |
| IPI00421761 | |
| IPI00134582 | |
| IPI00192928 |