| URN | urn:agi-llid:5547 |
|---|---|
| Total Entities | 0 |
| Connectivity | 111 |
| Name | Prcp |
| Description | prolylcarboxypeptidase (angiotensinase C) |
| Notes | The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| serine-type peptidase activity | |
| carboxypeptidase activity | |
| serine-type carboxypeptidase activity |
| GO Cellular Component | plasma membrane |
|---|---|
| lysosome |
| GO Biological Process | blood coagulation, intrinsic pathway |
|---|---|
| blood coagulation | |
| proteolysis |
| Pathway | kallikrein-kinin cascade pathway |
|---|---|
| kallikrein-kinin cascade pathway |
| Group | blood coagulation, intrinsic pathway |
|---|---|
| blood coagulation | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| carboxypeptidase activity | |
| serine-type carboxypeptidase activity | |
| proteolysis | |
| plasma membrane | |
| lysosome | |
| Biofluids assayable substances |
| LocusLink ID | 5547 |
|---|---|
| 72461 | |
| 293118 |
| Cell Localization | Lysosome |
|---|
| GO ID | 0004185 |
|---|---|
| 0007596 | |
| 0007597 | |
| 0006508 | |
| 0005764 | |
| 0005886 | |
| 0004180 | |
| 0016787 | |
| 0008233 | |
| 0008236 |
| Alias | PCP |
|---|---|
| HUMPCP | |
| lysosomal Pro-X carboxypeptidase | |
| angiotensinase C | |
| proline carboxypeptidase | |
| lysosomal carboxypeptidase C | |
| prolylcarboxypeptidase isoform 1 preproprotein | |
| AI451719 | |
| 2510048K03Rik | |
| 2610104A14Rik | |
| MGC2202 | |
| peptidylprolylamino acid carboxypeptidase | |
| RIKEN cDNA 2610104A14 gene | |
| PRCP | |
| angiotensinase C like | |
| proline-specific carboxypeptidase P | |
| prolyl carboxypeptidase | |
| prolylcarboxypeptidase (angiotensinase C) | |
| carboxypeptidase p | |
| peptidylprolyl amino acid hydrolase | |
| Prolylcarboxypeptidase | |
| 2510048K03 | |
| 2610104A14 | |
| LOC120474 | |
| angiotensinase | |
| angiotensinases | |
| LOC100048391 | |
| aminoacylproline carboxypeptidase |
| Mouse chromosome position | 7 |
|---|
| OMIM ID | 176785 |
|---|
| Rat chromosome position | 1q32 |
|---|
| Hugo ID | 9344 |
|---|
| Human chromosome position | 11q14 |
|---|
| Swiss-Prot Accession | P42785 |
|---|---|
| B7Z7Q6 | |
| Q7TMR0 | |
| D4AA31 | |
| A8MU24 | |
| B2R7B7 | |
| B3KRK5 | |
| B5BU34 | |
| Q3TLW3 | |
| Q3V302 | |
| Q8BKK3 | |
| Q8R0T8 | |
| Q9D049 |
| PIR ID | A47352 |
|---|
| Unigene ID | Hs.523936 |
|---|---|
| Mm.389969 | |
| Rn.8457 |
| KEGG ID | hsa:5547 |
|---|---|
| mmu:72461 | |
| rno:293118 |
| Swiss-Prot ID | PCP_HUMAN |
|---|---|
| PCP_MOUSE | |
| A8MU24_HUMAN | |
| B3KRK5_HUMAN | |
| B5BU34_HUMAN |
| EC Number | 3.4.16.2 |
|---|
| Ensembl ID | ENSG00000137509 |
|---|---|
| ENSP00000377055 | |
| ENST00000393399 | |
| ENSMUSG00000061119 | |
| ENSMUSP00000075429 | |
| ENSMUST00000076052 | |
| ENSRNOG00000010630 | |
| ENSRNOP00000014271 | |
| ENSRNOT00000014271 |
| Homologene ID | 55867 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1919711 |
|---|
| RGD ID | 1307842 |
|---|
| MedScan ID | 5547 |
|---|
| IPI ID | IPI00001593 |
|---|---|
| IPI00132020 | |
| IPI00968927 | |
| IPI00399307 | |
| IPI00364384 |