| URN | urn:agi-llid:3818 |
|---|---|
| Total Entities | 0 |
| Connectivity | 514 |
| Name | Klkb1 |
| Description | kallikrein B, plasma (Fletcher factor) 1 |
| Notes | Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq] |
| GO Molecular Function | catalytic activity |
|---|---|
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| plasma membrane | |
| extracellular space |
| GO Biological Process | blood coagulation, intrinsic pathway |
|---|---|
| Factor XII activation | |
| fibrinolysis | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| liver regeneration | |
| extracellular matrix disassembly | |
| extracellular matrix organization | |
| inflammatory response | |
| zymogen activation | |
| proteolysis | |
| plasminogen activation |
| Pathway | Coagulation Cascade |
|---|---|
| kallikrein-kinin cascade pathway | |
| coagulation cascade pathway | |
| kallikrein-kinin cascade pathway |
| Group | blood coagulation, intrinsic pathway |
|---|---|
| Factor XII activation | |
| fibrinolysis | |
| positive regulation of fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| liver regeneration | |
| extracellular matrix disassembly | |
| extracellular matrix organization | |
| inflammatory response | |
| catalytic activity | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| zymogen activation | |
| proteolysis | |
| plasminogen activation | |
| extracellular region | |
| plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 3818 |
|---|---|
| 16621 | |
| 25048 |
| Cell Localization | Secreted |
|---|
| GO ID | 0004252 |
|---|---|
| 0002542 | |
| 0007596 | |
| 0007597 | |
| 0022617 | |
| 0030198 | |
| 0042730 | |
| 0031639 | |
| 0051919 | |
| 0006508 | |
| 0031638 | |
| 0005576 | |
| 0005615 | |
| 0005886 | |
| 0003824 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0007599 | |
| 0006954 | |
| 0097421 | |
| 0005737 |
| Alias | PPK |
|---|---|
| KLK3 | |
| plasma kallikrein | |
| kininogenin | |
| Fletcher factor | |
| plasma prekallikrein | |
| plasma kallikrein heavy chain | |
| plasma kallikrein light chain | |
| APS | |
| PSA | |
| Kal3 | |
| Kal-3 | |
| kallikrein 3, plasma | |
| antigen, prostate specific | |
| Kalp1 | |
| KALP15 | |
| Pk | |
| OTTHUMP00000218136 | |
| serine protease-like I | |
| plasma kallikrein B | |
| serine protease-like 1 | |
| serine proteinase-like 1 | |
| serine proteinase-like I | |
| serum kallikrein | |
| serum kallikreins | |
| plasma B kallikrein | |
| OTTHUMP00000218135 | |
| prekallikrein | |
| plasma kallikrein B1 | |
| MGC108748 | |
| kallikrein B | |
| kallikrein B plasma | |
| kallikrein B, plasma (Fletcher factor) 1 | |
| kallikrein B, plasma (Fletcher factor) I | |
| kallikrein B, plasma 1 | |
| Klkb1 | |
| kallikrein I | |
| kallikrein II | |
| Kallikrein, plasma | |
| Klkb I | |
| kallikrein B, plasma I | |
| panceatic kallikreins | |
| panceatic kallikrein |
| Mouse chromosome position | 8 25.17 cM |
|---|---|
| 8 26.0 cM |
| OMIM ID | 229000 |
|---|---|
| 612423 |
| Rat chromosome position | 16q11 |
|---|
| Hugo ID | 6371 |
|---|
| Human chromosome position | 4q35 |
|---|---|
| 4q34-q35 |
| Swiss-Prot Accession | P03952 |
|---|---|
| P26262 | |
| Q5FVS2 | |
| P14272 | |
| A6NH96 | |
| B2R8H9 | |
| Q17RE8 | |
| Q17RE9 | |
| Q4W5C3 | |
| Q8R0P5 |
| PIR ID | A00921 |
|---|---|
| A36557 |
| Unigene ID | Hs.237642 |
|---|---|
| Mm.482691 | |
| Rn.9880 | |
| Mm.36341 |
| KEGG ID | hsa:3818 |
|---|---|
| mmu:16621 | |
| rno:25048 |
| Swiss-Prot ID | KLKB1_HUMAN |
|---|---|
| KLKB1_MOUSE | |
| Q5FVS2_RAT | |
| Q4W5C3_HUMAN | |
| Q8R0P5_MOUSE |
| EC Number | 3.4.21.34 |
|---|
| Ensembl ID | ENSG00000164344 |
|---|---|
| ENSP00000264690 | |
| ENST00000264690 | |
| ENSMUSG00000031640 | |
| ENSMUSP00000112174 | |
| ENSMUST00000116473 | |
| ENSRNOG00000014118 | |
| ENSRNOP00000019237 | |
| ENSRNOT00000019237 |
| Homologene ID | 68097 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 102849 |
|---|
| RGD ID | 67382 |
|---|
| MedScan ID | 3818 |
|---|
| IPI ID | IPI00113057 |
|---|---|
| IPI00654888 | |
| IPI00882500 | |
| IPI00930810 | |
| IPI00879718 | |
| IPI00879551 | |
| IPI00879984 | |
| IPI00203384 |