| URN | urn:agi-llid:710 |
|---|---|
| Total Entities | 0 |
| Connectivity | 717 |
| Name | Serping1 |
| Description | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 |
| Notes | This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq] |
| GO Molecular Function | peptidase inhibitor activity |
|---|---|
| serine-type endopeptidase inhibitor activity | |
| complement binding |
| GO Cellular Component | extracellular region |
|---|---|
| platelet alpha granule lumen | |
| extracellular space |
| GO Biological Process | immune system process |
|---|---|
| negative regulation of complement activation | |
| complement activation, classical pathway | |
| negative regulation of complement activation, lectin pathway | |
| innate immune response | |
| blood coagulation, intrinsic pathway | |
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| platelet activation | |
| blood circulation | |
| platelet degranulation | |
| regulation of proteolysis | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity |
| Pathway | Proteins Involved in Pathogenesis of Neuroblastoma |
|---|---|
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| kallikrein-kinin cascade pathway | |
| coagulation cascade pathway | |
| kallikrein-kinin cascade pathway |
| Group | immune system process |
|---|---|
| negative regulation of complement activation | |
| complement activation, classical pathway | |
| negative regulation of complement activation, lectin pathway | |
| innate immune response | |
| blood coagulation, intrinsic pathway | |
| fibrinolysis | |
| hemostasis | |
| blood coagulation | |
| regulation of blood coagulation | |
| platelet activation | |
| blood circulation | |
| platelet degranulation | |
| regulation of proteolysis | |
| peptidase inhibitor activity | |
| serine-type endopeptidase inhibitor activity | |
| negative regulation of peptidase activity | |
| negative regulation of endopeptidase activity | |
| complement binding | |
| extracellular region | |
| platelet alpha granule lumen | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 710 |
|---|---|
| 12258 | |
| 295703 |
| Cell Localization | Secreted |
|---|
| GO ID | 0004867 |
|---|---|
| 0008015 | |
| 0007596 | |
| 0007597 | |
| 0006958 | |
| 0042730 | |
| 0045087 | |
| 0001869 | |
| 0010951 | |
| 0030168 | |
| 0002576 | |
| 0005576 | |
| 0005615 | |
| 0031093 | |
| 0001848 | |
| 0030414 | |
| 0007599 | |
| 0002376 | |
| 0045916 | |
| 0010466 | |
| 0030193 | |
| 0030162 |
| Alias | C1IN |
|---|---|
| C1NH | |
| HAE1 | |
| HAE2 | |
| C1INH | |
| plasma protease C1 inhibitor | |
| serpin G1 | |
| C1-inhibiting factor | |
| C1 esterase inhibitor | |
| complement component 1 inhibitor | |
| serine/cysteine proteinase inhibitor clade G member 1 | |
| RP23-399J8.3 | |
| C1 Inh | |
| C1 inhibitor | |
| serine (or cysteine) proteinase inhibitor, clade G, member 1 | |
| serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1 | |
| serpin peptidase inhibitor, clade G, member 1 | |
| serine (or cysteine) peptidase inhibitor, clade G, member 1 | |
| serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | |
| c1s inhibitor | |
| complement C1 inactivator proteins | |
| complement C1 inactivator protein | |
| complement c1 esterase inhibitor | |
| complement 1 inhibitor | |
| complement 1 inactivators | |
| Serping I | |
| serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | |
| conestat alpha | |
| c 1 inactivator | |
| berinert | |
| alpha 1 neuraminoglycoprotein | |
| Serping1 | |
| complement C1 inhibitor protein | |
| cinryze | |
| esterase c 1 inhibitor | |
| serine (or cysteine) proteinase inhibitor, clade G (C1 inhibitor), member I | |
| ruconest | |
| rhucin | |
| complement subcomponent c1s inhibitor | |
| esterase c1 inhibition | |
| complement component C1 esterase inhibitor | |
| conestat alfa | |
| complement inactivating factor | |
| complement component inactivator | |
| complement component C1s inhibitor | |
| complement component c1 inhibitor | |
| complement component c1 inactivator | |
| recombinant human C1 inhibitor | |
| serine/cysteine protease inhibitor clade G member 1 | |
| C1-INHs | |
| HAE I | |
| MGC72585 | |
| OTTHUMP00000197004 | |
| OTTMUSP00000014648 | |
| serine (or cysteine) protease inhibitor, clade G, member I | |
| serine (or cysteine)ase inhibitor, clade G, member I | |
| serine (or cysteine)ase inhibitor, clade G, member 1 | |
| serine (or cysteine) proteinase inhibitor, clade G, member I | |
| OTTMUSP00000014647 | |
| Plasma proteinase C1 inhibitor | |
| serine (or cysteine) protease inhibitor, clade G, member 1 | |
| serine (or cysteine) protease inhibitor, clade G (C1 inhibitor), member I | |
| serine (or cysteine) protease inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary) | |
| serine (or cysteine) protease inhibitor, clade G (C1 inhibitor), member 1 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 606860 |
|---|---|
| 120790 | |
| 106100 |
| Rat chromosome position | 3q24 |
|---|
| Hugo ID | 1228 |
|---|
| Human chromosome position | 11q12.1 |
|---|---|
| 11q12-q13.1 |
| Swiss-Prot Accession | E9KL26 |
|---|---|
| P05155 | |
| B4E1F0 | |
| P97290 | |
| Q6P734 | |
| A6NMU0 | |
| A8KAI9 | |
| B2R6L5 | |
| Q16304 | |
| Q547W3 | |
| Q59EI5 | |
| Q7Z455 | |
| Q96FE0 | |
| Q9UC49 | |
| Q9UCF9 | |
| A2ATR7 | |
| O88330 | |
| Q99M43 | |
| Q9QX09 | |
| Q5UGI5 | |
| Q5UGI6 |
| PIR ID | S15386 |
|---|
| Unigene ID | Hs.384598 |
|---|---|
| Mm.38888 | |
| Rn.100285 |
| KEGG ID | hsa:710 |
|---|---|
| mmu:12258 | |
| rno:295703 |
| Swiss-Prot ID | IC1_HUMAN |
|---|---|
| IC1_RAT | |
| IC1_MOUSE | |
| A2ATR7_MOUSE |
| Ensembl ID | ENSG00000149131 |
|---|---|
| ENSP00000278407 | |
| ENST00000278407 | |
| ENSP00000367574 | |
| ENST00000378323 | |
| ENSMUSG00000023224 | |
| ENSMUSP00000023994 | |
| ENSMUST00000023994 | |
| ENSRNOG00000007457 | |
| ENSRNOP00000009817 | |
| ENSRNOT00000009817 |
| Homologene ID | 44 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 894696 |
|---|
| RGD ID | 735225 |
|---|
| MedScan ID | 710 |
|---|
| IPI ID | IPI00372792 |
|---|---|
| IPI00122977 | |
| IPI00291866 | |
| IPI00881377 | |
| IPI00556459 | |
| IPI00385045 | |
| IPI00479178 | |
| IPI00879931 | |
| IPI00879796 | |
| IPI00877850 | |
| IPI00877698 | |
| IPI00750580 |