| URN | urn:agi-llid:1368 |
|---|---|
| Total Entities | 0 |
| Connectivity | 51 |
| Name | Cpm |
| Description | carboxypeptidase M |
| Notes | The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|
| GO Molecular Function | metal ion binding |
|---|---|
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| carboxypeptidase activity | |
| metallocarboxypeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| nucleolus | |
| anchored to membrane | |
| plasma membrane | |
| cytoplasm | |
| nucleus |
| GO Biological Process | anatomical structure morphogenesis |
|---|---|
| proteolysis |
| Pathway | kallikrein-kinin cascade pathway |
|---|---|
| kallikrein-kinin cascade pathway |
| Group | anatomical structure morphogenesis |
|---|---|
| proteolysis | |
| metal ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| carboxypeptidase activity | |
| metallocarboxypeptidase activity | |
| membrane | |
| nucleolus | |
| anchored to membrane | |
| plasma membrane | |
| cytoplasm | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 1368 |
|---|
| Hugo ID | 2311 |
|---|
| Human chromosome position | 12q14.3 |
|---|
| LocusLink ID | 1368 |
|---|---|
| 70574 | |
| 314855 |
| Alias | carboxypeptidase M |
|---|---|
| renal carboxypeptidase | |
| urinary carboxypeptidase B | |
| AA589379 | |
| 1110060I01Rik | |
| 5730456K23Rik | |
| E030045M14Rik | |
| E030045M14 | |
| 1110060I01 | |
| MGC118152 | |
| 5730456K23 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 114860 |
|---|
| Unigene ID | Hs.654387 |
|---|---|
| Mm.339332 | |
| Rn.23887 |
| KEGG ID | hsa:1368 |
|---|---|
| mmu:70574 | |
| rno:314855 |
| Swiss-Prot Accession | P14384 |
|---|---|
| Q80V42 | |
| D4A9Q5 | |
| Q497S5 | |
| Q9CYH8 | |
| B2R800 | |
| Q9H2K9 |
| EC Number | 3.4.17.12 |
|---|
| GO ID | 0004180 |
|---|---|
| 0004181 | |
| 0008270 | |
| 0009653 | |
| 0006508 | |
| 0031225 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0016787 | |
| 0046872 | |
| 0008237 | |
| 0008233 | |
| 0016020 |
| PIR ID | A32619 |
|---|
| Swiss-Prot ID | CBPM_MOUSE |
|---|---|
| CBPM_HUMAN |
| Cell Localization | Cell membrane |
|---|
| IPI ID | IPI00896666 |
|---|---|
| IPI00896674 | |
| IPI00026270 | |
| IPI00794541 | |
| IPI00869863 |
| Mouse chromosome position | 10 |
|---|
| Rat chromosome position | 7q22 |
|---|
| Homologene ID | 35367 |
|---|
| MGI ID | 1917824 |
|---|
| RGD ID | 1310532 |
|---|