| URN | urn:agi-llid:624 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1049 |
| Name | Bdkrb2 |
| Description | bradykinin receptor B2 |
| Notes | This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. [provided by RefSeq] |
| GO Molecular Function | signal transducer activity |
|---|---|
| G-protein coupled receptor activity | |
| bradykinin receptor activity | |
| phosphatidylinositol phospholipase C activity | |
| type 1 angiotensin receptor binding | |
| protease binding | |
| protein heterodimerization activity |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| plasma membrane | |
| endosome |
| GO Biological Process | acute inflammatory response to antigenic stimulus |
|---|---|
| sensory perception of pain | |
| smooth muscle contraction | |
| blood circulation | |
| regulation of vascular permeability | |
| vasodilation | |
| vasoconstriction | |
| regulation of vasoconstriction | |
| negative regulation of blood pressure | |
| maintenance of blood-brain barrier | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator | |
| G-protein coupled receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| positive regulation of cytosolic calcium ion concentration | |
| negative regulation of apoptotic process | |
| negative regulation of cell proliferation | |
| arachidonic acid secretion | |
| response to stress | |
| response to drug | |
| cellular response to hypoxia | |
| inflammatory response | |
| response to salt stress | |
| negative regulation of peptidyl-serine phosphorylation |
| Pathway | Transcytosis |
|---|---|
| Proteins Involved in Pathogenesis of Epilepsy | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| BDKRB1/2 -> prostaglandin generation | |
| BDKRB1/2 -> interleukins production | |
| BDKRB1/2 -> vasodilation | |
| BDKRB1/2 -> ion channels | |
| Summarized nociception-related expression targets | |
| Summarized vascular motility pathway | |
| Regulation of calcium flux | |
| BradykininR -> STAT3 signaling | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| kallikrein-kinin cascade pathway | |
| kinin signaling pathway | |
| kallikrein-kinin cascade pathway |
| Group | GPCR/GqCR |
|---|---|
| acute inflammatory response to antigenic stimulus | |
| sensory perception of pain | |
| smooth muscle contraction | |
| blood circulation | |
| regulation of vascular permeability | |
| vasodilation | |
| vasoconstriction | |
| regulation of vasoconstriction | |
| negative regulation of blood pressure | |
| maintenance of blood-brain barrier | |
| signal transduction | |
| cell surface receptor signaling pathway | |
| signal transducer activity | |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress | |
| negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator | |
| G-protein coupled receptor activity | |
| bradykinin receptor activity | |
| G-protein coupled receptor signaling pathway | |
| transmembrane receptor protein tyrosine kinase signaling pathway | |
| positive regulation of cytosolic calcium ion concentration | |
| negative regulation of apoptotic process | |
| negative regulation of cell proliferation | |
| arachidonic acid secretion | |
| response to stress | |
| response to drug | |
| cellular response to hypoxia | |
| inflammatory response | |
| response to salt stress | |
| negative regulation of peptidyl-serine phosphorylation | |
| phosphatidylinositol phospholipase C activity | |
| type 1 angiotensin receptor binding | |
| protease binding | |
| protein heterodimerization activity | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| plasma membrane | |
| endosome | |
| Secreted proteins |
| LocusLink ID | 624 |
|---|---|
| 12062 | |
| 25245 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane |
| GO ID | 0004947 |
|---|---|
| 0004435 | |
| 0002020 | |
| 0046982 | |
| 0031702 | |
| 0007186 | |
| 0050482 | |
| 0008015 | |
| 0007166 | |
| 0006954 | |
| 0043066 | |
| 0033137 | |
| 0007204 | |
| 0043114 | |
| 0019229 | |
| 0009651 | |
| 0006939 | |
| 0007169 | |
| 0042310 | |
| 0042311 | |
| 0005768 | |
| 0005887 | |
| 0005886 | |
| 0004930 | |
| 0004871 | |
| 0002438 | |
| 0035633 | |
| 0045776 | |
| 0008285 | |
| 1902219 | |
| 1902239 | |
| 0006950 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0071456 | |
| 0042493 | |
| 0019233 | |
| 0004872 |
| Alias | B2R |
|---|---|
| BK2 | |
| BK-2 | |
| BKR2 | |
| BRB2 | |
| B2 bradykinin receptor | |
| BK-2 receptor | |
| B2 | |
| B(2) | |
| BK2R | |
| kinin B2 | |
| B2BKR | |
| B2BRA | |
| bradykinin receptor, beta 2 | |
| bradykinin 2 receptor | |
| Bradykinin B2 receptor | |
| Bradykinin receptor B2 | |
| bradykinin receptor, beta II | |
| Bradykinin B2 receptors | |
| DKFZp686O088 | |
| BK2 receptor | |
| BDKRB2 | |
| B2 receptors | |
| B2 receptor | |
| B2 bradykinin receptors | |
| BK2 receptors |
| Mouse chromosome position | 12 55.76 cM |
|---|---|
| 12 53.0 cM |
| OMIM ID | 113503 |
|---|
| Rat chromosome position | 6q32 |
|---|
| Hugo ID | 1030 |
|---|
| Human chromosome position | 14q32.1-q32.2 |
|---|
| Swiss-Prot Accession | P30411 |
|---|---|
| P32299 | |
| G3V942 | |
| P25023 | |
| B9EHE3 | |
| D4AA73 | |
| Q68DM8 | |
| Q6LAU9 |
| PIR ID | JH0712 |
|---|---|
| A41283 | |
| I49519 |
| Unigene ID | Hs.654542 |
|---|---|
| Hs.726620 | |
| Mm.390475 | |
| Rn.9845 | |
| Hs.713515 | |
| Hs.724899 |
| KEGG ID | hsa:624 |
|---|---|
| mmu:12062 | |
| rno:25245 |
| Swiss-Prot ID | BKRB2_HUMAN |
|---|---|
| BKRB2_RAT | |
| BKRB2_MOUSE | |
| B9EHE3_MOUSE |
| Ensembl ID | ENSG00000168398 |
|---|---|
| ENSP00000307713 | |
| ENST00000306005 | |
| ENSP00000439459 | |
| ENST00000542454 | |
| ENSP00000450482 | |
| ENST00000554311 | |
| ENSMUSG00000021070 | |
| ENSMUSP00000001652 | |
| ENSMUST00000001652 |
| Homologene ID | 519 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 102845 |
|---|
| RGD ID | 2201 |
|---|
| MedScan ID | 624 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00209884 |
|---|---|
| IPI00231807 | |
| IPI00136814 | |
| IPI00226768 | |
| IPI00026534 | |
| IPI00218209 | |
| IPI00780640 | |
| IPI00778908 |