| URN | urn:agi-llid:623 |
|---|---|
| Total Entities | 0 |
| Connectivity | 571 |
| Name | Bdkrb1 |
| Description | bradykinin receptor B1 |
| Notes | Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq] |
| GO Molecular Function | signal transducer activity |
|---|---|
| G-protein coupled receptor activity | |
| bradykinin receptor activity | |
| peptide binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of plasma membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| neuron projection |
| GO Biological Process | positive regulation of leukocyte migration |
|---|---|
| sensory perception of pain | |
| negative regulation of blood pressure | |
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| protein kinase C-activating G-protein coupled receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of cytosolic calcium ion concentration | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| cell migration | |
| response to stress | |
| response to lipopolysaccharide | |
| inflammatory response | |
| response to mechanical stimulus | |
| negative regulation of protein phosphorylation |
| Pathway | Proteins Involved in Pathogenesis of Epilepsy |
|---|---|
| BDKRB1/2 -> prostaglandin generation | |
| BDKRB1/2 -> interleukins production | |
| BDKRB1/2 -> vasodilation | |
| BDKRB1/2 -> ion channels | |
| Summarized nociception-related expression targets | |
| Summarized vascular motility pathway | |
| Regulation of calcium flux | |
| kallikrein-kinin cascade pathway | |
| kinin signaling pathway | |
| kallikrein-kinin cascade pathway |
| Group | GPCR/GqCR |
|---|---|
| positive regulation of leukocyte migration | |
| sensory perception of pain | |
| negative regulation of blood pressure | |
| signal transduction | |
| signal transducer activity | |
| G-protein coupled receptor activity | |
| bradykinin receptor activity | |
| G-protein coupled receptor signaling pathway | |
| protein kinase C-activating G-protein coupled receptor signaling pathway | |
| negative regulation of cell growth | |
| positive regulation of cytosolic calcium ion concentration | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| cell migration | |
| response to stress | |
| response to lipopolysaccharide | |
| inflammatory response | |
| response to mechanical stimulus | |
| negative regulation of protein phosphorylation | |
| peptide binding | |
| membrane | |
| integral component of membrane | |
| integral component of plasma membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| neuron projection | |
| Secreted proteins |
| LocusLink ID | 623 |
|---|---|
| 12061 | |
| 81509 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane |
| GO ID | 0004947 |
|---|---|
| 0042277 | |
| 0016477 | |
| 0006954 | |
| 0045776 | |
| 0030308 | |
| 0001933 | |
| 0007204 | |
| 0002687 | |
| 0051281 | |
| 0007205 | |
| 0032496 | |
| 0009612 | |
| 0019233 | |
| 0005783 | |
| 0005887 | |
| 0043005 | |
| 0005886 | |
| 0004930 | |
| 0004871 | |
| 0007186 | |
| 0006950 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0004872 | |
| 0005624 |
| Alias | B1R |
|---|---|
| BKR1 | |
| B1BKR | |
| BKB1R | |
| BRADYB1 | |
| B1 bradykinin receptor | |
| BK-1 receptor | |
| bradykinin receptor 1 | |
| bradykinin B1 receptor | |
| Bdkrb | |
| kinin B1 | |
| BKR | |
| KB1 | |
| kinin B1 receptor | |
| bradykinin receptor, beta 1 | |
| Bradykinin receptor B1 | |
| bradykinin receptor I | |
| bradykinin 1 receptor | |
| BRADYB I | |
| BDKRB I | |
| bradykinin receptor, beta | |
| B1 bradykinin receptors | |
| BK-1 receptors | |
| BKR I | |
| BDKRB1 |
| Mouse chromosome position | 12 |
|---|
| OMIM ID | 600337 |
|---|
| Rat chromosome position | 6q32 |
|---|
| Hugo ID | 1029 |
|---|
| Human chromosome position | 14q32.1-q32.2 |
|---|
| Swiss-Prot Accession | P46663 |
|---|---|
| G3V4Y2 | |
| Q0VBD7 | |
| Q61125 | |
| P97583 | |
| A8K7F5 | |
| Q546S7 | |
| Q8N0Y8 | |
| Q9Z1F4 | |
| O35782 | |
| Q9R250 | |
| Q71U72 |
| PIR ID | A53858 |
|---|---|
| JC4681 |
| Unigene ID | Hs.525572 |
|---|---|
| Mm.377078 | |
| Rn.10762 |
| KEGG ID | hsa:623 |
|---|---|
| mmu:12061 | |
| rno:81509 |
| Swiss-Prot ID | BKRB1_HUMAN |
|---|---|
| BKRB1_MOUSE | |
| BKRB1_RAT | |
| Q0VBD7_MOUSE | |
| A8K7F5_HUMAN |
| Ensembl ID | ENSG00000100739 |
|---|---|
| ENSP00000452064 | |
| ENST00000553356 | |
| ENSMUSG00000041347 | |
| ENSMUSP00000045335 | |
| ENSMUST00000041229 | |
| ENSRNOG00000004488 | |
| ENSRNOP00000005953 | |
| ENSRNOT00000005953 |
| Homologene ID | 570 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88144 |
|---|
| RGD ID | 620401 |
|---|
| MedScan ID | 623 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00117779 |
|---|---|
| IPI00205635 | |
| IPI00296538 |