| URN | urn:agi-llid:1369 |
|---|---|
| Total Entities | 0 |
| Connectivity | 124 |
| Name | Cpn1 |
| Description | carboxypeptidase N, polypeptide 1 |
| Notes | Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq] |
| Ariadne Ontology | Secreted proteins |
|---|---|
| Biofluids assayable substances |
| GO Molecular Function | metal ion binding |
|---|---|
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| carboxypeptidase activity | |
| metallocarboxypeptidase activity |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| GO Biological Process | metabolic process |
|---|---|
| response to glucocorticoid stimulus | |
| proteolysis |
| Pathway | kallikrein-kinin cascade pathway |
|---|---|
| kallikrein-kinin cascade pathway |
| Group | metabolic process |
|---|---|
| response to glucocorticoid stimulus | |
| proteolysis | |
| metal ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| carboxypeptidase activity | |
| metallocarboxypeptidase activity | |
| extracellular region | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1369 |
|---|
| Hugo ID | 2312 |
|---|
| Human chromosome position | 10q24.2 |
|---|
| LocusLink ID | 1369 |
|---|---|
| 93721 | |
| 365466 |
| Alias | CPN |
|---|---|
| SCPN | |
| carboxypeptidase N catalytic chain | |
| kininase I | |
| kininase-1 | |
| carboxypeptidase K | |
| lysine carboxypeptidase | |
| serum carboxypeptidase N | |
| anaphylatoxin inactivator | |
| arginine carboxypeptidase | |
| plasma carboxypeptidase B | |
| carboxypeptidase N small subunit | |
| carboxypeptidase N catalytic subunit | |
| carboxypeptidase N polypeptide 1 50 kD | |
| 0610011F20Rik | |
| carboxypeptidase N, polypeptide 1, 50kD | |
| ACBP | |
| OTTHUMP00000020269 | |
| MGC108636 | |
| Kininase 1 | |
| FLJ40792 | |
| Cpn I | |
| carboxypeptidase N | |
| 0610011F20 | |
| Cpn1 | |
| carboxypeptidase N, polypeptide 1 | |
| carboxypeptidase N, polypeptide I | |
| 50 kDa carboxypeptidase N, polypeptide 1, |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603103 |
|---|---|
| 212070 |
| Unigene ID | Hs.2246 |
|---|---|
| Mm.206774 | |
| Rn.145303 | |
| Rn.162532 |
| KEGG ID | hsa:1369 |
|---|---|
| mmu:93721 | |
| rno:365466 |
| Swiss-Prot Accession | B1AP59 |
|---|---|
| P15169 | |
| Q9JJN5 | |
| Q91WM9 | |
| Q9EQV8 |
| EC Number | 3.4.17.3 |
|---|
| GO ID | 0004181 |
|---|---|
| 0008270 | |
| 0006508 | |
| 0051384 | |
| 0005615 | |
| 0004180 | |
| 0016787 | |
| 0046872 | |
| 0008237 | |
| 0008233 | |
| 0008152 | |
| 0005576 | |
| 0004182 |
| PIR ID | A30798 |
|---|---|
| S02074 |
| Swiss-Prot ID | CBPN_MOUSE |
|---|---|
| CBPN_HUMAN | |
| CBPN_RAT | |
| B1AP59_HUMAN |
| Cell Localization | Secreted |
|---|---|
| extracellular space |
| IPI ID | IPI00128260 |
|---|---|
| IPI00010295 | |
| IPI00190500 | |
| IPI00641144 |
| Mouse chromosome position | 19 47.0 cM |
|---|
| Rat chromosome position | 1q54 |
|---|
| Homologene ID | 1002 |
|---|
| MGI ID | 2135874 |
|---|
| RGD ID | 70931 |
|---|