| URN | urn:agi-llid:623 |
|---|---|
| Total Entities | 0 |
| Connectivity | 319 |
| Name | Bdkrb1 |
| Description | bradykinin receptor B1 |
| Notes | Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses. [provided by RefSeq] |
| Ariadne Ontology | GPCR-GqCR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | peptide binding |
|---|---|
| G-protein coupled receptor activity | |
| bradykinin receptor activity | |
| signal transducer activity |
| GO Cellular Component | membrane |
|---|---|
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| neuron projection |
| GO Biological Process | signal transduction |
|---|---|
| G-protein coupled receptor signaling pathway | |
| protein kinase C-activating G-protein coupled receptor signaling pathway | |
| negative regulation of cell growth | |
| negative regulation of protein phosphorylation | |
| positive regulation of leukocyte migration | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| elevation of cytosolic calcium ion concentration | |
| cell migration | |
| response to lipopolysaccharide | |
| inflammatory response | |
| sensory perception of pain | |
| negative regulation of blood pressure |
| Pathway | kallikrein-kinin cascade pathway |
|---|---|
| kinin signaling pathway first | |
| kinin signaling pathway | |
| kallikrein-kinin cascade pathway |
| Group | GPCR-GqCR |
|---|---|
| signal transduction | |
| G-protein coupled receptor signaling pathway | |
| protein kinase C-activating G-protein coupled receptor signaling pathway | |
| negative regulation of cell growth | |
| negative regulation of protein phosphorylation | |
| positive regulation of leukocyte migration | |
| positive regulation of release of sequestered calcium ion into cytosol | |
| elevation of cytosolic calcium ion concentration | |
| cell migration | |
| response to lipopolysaccharide | |
| inflammatory response | |
| sensory perception of pain | |
| negative regulation of blood pressure | |
| peptide binding | |
| G-protein coupled receptor activity | |
| bradykinin receptor activity | |
| signal transducer activity | |
| membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| endoplasmic reticulum | |
| neuron projection | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 623 |
|---|
| Hugo ID | 1029 |
|---|
| Human chromosome position | 14q32.1-q32.2 |
|---|
| LocusLink ID | 623 |
|---|---|
| 12061 | |
| 81509 |
| Alias | B1R |
|---|---|
| BKR1 | |
| B1BKR | |
| BKB1R | |
| BRADYB1 | |
| B1 bradykinin receptor | |
| BK-1 receptor | |
| bradykinin receptor 1 | |
| bradykinin B1 receptor | |
| Bdkrb | |
| kinin B1 | |
| BKR | |
| KB1 | |
| kinin B1 receptor | |
| bradykinin receptor, beta 1 | |
| bradykinin receptor I | |
| Bradykinin receptor B1 | |
| bradykinin receptor, beta | |
| BRADYB I | |
| BDKRB1 | |
| B1 bradykinin receptors | |
| BDKRB I | |
| BK-1 receptors | |
| BKR I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600337 |
|---|
| Unigene ID | Hs.525572 |
|---|---|
| Mm.377078 | |
| Rn.10762 |
| KEGG ID | hsa:623 |
|---|---|
| mmu:12061 | |
| rno:81509 |
| Swiss-Prot Accession | P46663 |
|---|---|
| Q0VBD7 | |
| Q61125 | |
| P97583 | |
| Q9Z1F4 | |
| O35782 | |
| Q9R250 | |
| A8K7F5 | |
| Q546S7 | |
| Q8N0Y8 | |
| Q71U72 |
| GO ID | 0004947 |
|---|---|
| 0042277 | |
| 0016477 | |
| 0007204 | |
| 0006954 | |
| 0045776 | |
| 0030308 | |
| 0001933 | |
| 0002687 | |
| 0051281 | |
| 0007205 | |
| 0032496 | |
| 0019233 | |
| 0005783 | |
| 0005887 | |
| 0043005 | |
| 0005886 | |
| 0004930 | |
| 0004871 | |
| 0007186 | |
| 0007165 | |
| 0016021 | |
| 0016020 | |
| 0004872 | |
| 0005624 |
| PIR ID | JC4681 |
|---|---|
| A53858 |
| Swiss-Prot ID | BKRB1_MOUSE |
|---|---|
| BKRB1_RAT | |
| BKRB1_HUMAN | |
| Q0VBD7_MOUSE | |
| A8K7F5_HUMAN |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00117779 |
|---|---|
| IPI00205635 | |
| IPI00296538 |
| Mouse chromosome position | 12 |
|---|
| Rat chromosome position | 6q32 |
|---|
| Homologene ID | 570 |
|---|
| MGI ID | 88144 |
|---|
| RGD ID | 620401 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|