Protein Kng1

URN	urn:agi-llid:589
Total Entities	0
Connectivity	2568
Name	Kng1
Description	kininogen 1
Notes	This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

GO Molecular Function	peptidase inhibitor activity
	cysteine-type endopeptidase inhibitor activity
	receptor binding
	heparin binding
	zinc ion binding

GO Cellular Component	extracellular region
	platelet alpha granule lumen
	plasma membrane
	extracellular space

GO Biological Process	blood coagulation, intrinsic pathway
	positive regulation of renal sodium excretion
	negative regulation of blood coagulation
	hemostasis
	blood coagulation
	platelet activation
	positive regulation of urine volume
	smooth muscle contraction
	regulation of blood vessel size
	vasodilation
	platelet degranulation
	negative regulation of cell adhesion
	positive regulation of cytosolic calcium ion concentration
	positive regulation of apoptotic process
	inflammatory response
	negative regulation of peptidase activity

Pathway	Coagulation Cascade
	Proteins Involved in Pathogenesis of Cystic Fibrosis
	Proteins Involved in Pathogenesis of Pulmonary Hypertension
	Proteins Involved in Pathogenesis of Glioma
	Proteins Involved in Pathogenesis of Astrocytoma
	Proteins Involved in Pathogenesis of Neuroblastoma
	Proteins Involved in Pathogenesis of Myocardial Ischemia
	BDKRB1/2 -> prostaglandin generation
	BDKRB1/2 -> interleukins production
	BDKRB1/2 -> vasodilation
	BDKRB1/2 -> ion channels
	kallikrein-kinin cascade pathway
	kallikrein-kinin cascade pathway

Group	Neuromodulator
	blood coagulation, intrinsic pathway
	positive regulation of renal sodium excretion
	negative regulation of blood coagulation
	hemostasis
	blood coagulation
	platelet activation
	positive regulation of urine volume
	smooth muscle contraction
	regulation of blood vessel size
	vasodilation
	platelet degranulation
	negative regulation of cell adhesion
	positive regulation of cytosolic calcium ion concentration
	positive regulation of apoptotic process
	inflammatory response
	peptidase inhibitor activity
	cysteine-type endopeptidase inhibitor activity
	negative regulation of peptidase activity
	receptor binding
	heparin binding
	zinc ion binding
	extracellular region
	platelet alpha granule lumen
	plasma membrane
	extracellular space
	Secreted proteins
	Biofluids assayable substances

Alias	BK
	BDK
	KNG
	kininogen-1
	HMWK
	bradykinin
	fitzgerald factor
	high molecular weight kininogen
	alpha-2-thiol proteinase inhibitor
	williams-Fitzgerald-Flaujeac factor
	H-kininigen
	L-kininogen
	kininogen 2
	Kininogen-II
	kininogen II
	KNG1
	RATKINKG
	OTTHUMP00000210109
	MGC123404
	MGC117836
	major acute phase protein
	Kngt1
	RATKINKH
	Kng2
	T-kininogen 1
	Kng_v1
	Kng_v I
	Kngt
	RATKINT1G
	RATTKG6
	T-kininogen
	Kngk
	T-kininogen 2
	t-kininogen I
	T-kininogen II
	flaujeac factor
	williams factor
	HMW kininogen
	TKG6
	alpha-1 major acute phase protein prepeptide
	k-kininogen
	Kngt I
	kininogen 1-like 1
	Kng1_v1
	Kng1l1
	LMW T-kininogen I
	low molecular weight (LMW) T-kininogen II
	MGC108747
	MGC123437
	MGC93589
	thiostatin
	alpha-1-MAP
	Alpha-2-thiol protease inhibitor
	kininogen I
	KINT1G
	KINKH
	KINKG
	OTTMUSP00000031626
	kininogen 1, variant 1
	kininogen 1
	see also D11Elh1 and D11Mit
	T-kininogen, see also D11Elh1 and D11Mit8
	kininogen
	K-kininogen, differential splicing leads to HMW Kngk
	major acute phase protein (alpha-1-MAP)

Mouse chromosome position	16

OMIM ID	612358
	228960

Rat chromosome position	11q23

Hugo ID	6383

Human chromosome position	3q27

Homologene ID	88343

MGI ID	1097705
	3027157

RGD ID	2980

MedScan ID	589
	16644

Primary Cell Localization	Extracellular