| URN | urn:agi-llid:3572 |
|---|---|
| Total Entities | 0 |
| Connectivity | 685 |
| Name | IL6st |
| Description | interleukin 6 signal transducer (gp130, oncostatin M receptor) |
| Notes | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq] |
| Ariadne Ontology | CytokineR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | growth factor binding |
|---|---|
| ciliary neurotrophic factor receptor binding | |
| interleukin-6 receptor binding | |
| interleukin-6 binding | |
| interleukin-11 binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| cytokine receptor activity | |
| interleukin-6 receptor activity | |
| interleukin-27 receptor activity | |
| interleukin-11 receptor activity | |
| oncostatin-M receptor activity | |
| ciliary neurotrophic factor receptor activity | |
| leukemia inhibitory factor receptor activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| interleukin-6 receptor complex | |
| ciliary neurotrophic factor receptor complex | |
| external side of plasma membrane | |
| oncostatin-M receptor complex | |
| neuronal cell body membrane | |
| integral to membrane | |
| plasma membrane | |
| cell body | |
| dendrite | |
| neuronal cell body | |
| extracellular space |
| GO Biological Process | regulation of hormone secretion |
|---|---|
| regulation of Notch signaling pathway | |
| negative regulation of interleukin-6-mediated signaling pathway | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| positive regulation of tyrosine phosphorylation of Stat1 protein | |
| signal transduction | |
| JAK-STAT cascade | |
| cytokine-mediated signaling pathway | |
| interleukin-27-mediated signaling pathway | |
| ciliary neurotrophic factor-mediated signaling pathway | |
| oncostatin-M-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| interleukin-11-mediated signaling pathway | |
| leukemia inhibitory factor signaling pathway | |
| positive regulation of cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of osteoblast differentiation | |
| positive regulation of astrocyte differentiation | |
| glycogen metabolic process | |
| triglyceride mobilization | |
| reduction of cytosolic calcium ion concentration | |
| positive regulation of adaptive immune response | |
| response to nutrient | |
| response to cytokine stimulus | |
| positive regulation of acute inflammatory response | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of cardiac muscle hypertrophy |
| Pathway | IL6R -> STAT signaling |
|---|---|
| IL6ST -> STAT5B signaling | |
| IL11R -> STAT3 signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| OncostatinR -> STAT3 signaling | |
| LIFR -> STAT5A signaling | |
| CNTFR -> STAT3 signaling | |
| IL6 Expression Targets | |
| IL11 Expression Targets | |
| LIF Expression Targets | |
| CTF1 Expression Targets | |
| OSM-IL6ST/LIFR Expression Targets | |
| CNTF Expression Targets | |
| CLCF1 Expression Targets | |
| OSM-OSMR Expression Targets | |
| Interleukin-6 signaling pathway | |
| interleukin-6 signaling pathway |
| Group | CytokineR |
|---|---|
| regulation of hormone secretion | |
| regulation of Notch signaling pathway | |
| negative regulation of interleukin-6-mediated signaling pathway | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| positive regulation of tyrosine phosphorylation of Stat1 protein | |
| signal transduction | |
| JAK-STAT cascade | |
| cytokine-mediated signaling pathway | |
| interleukin-27-mediated signaling pathway | |
| ciliary neurotrophic factor-mediated signaling pathway | |
| oncostatin-M-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| interleukin-11-mediated signaling pathway | |
| leukemia inhibitory factor signaling pathway | |
| positive regulation of cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of osteoblast differentiation | |
| positive regulation of astrocyte differentiation | |
| glycogen metabolic process | |
| triglyceride mobilization | |
| reduction of cytosolic calcium ion concentration | |
| positive regulation of adaptive immune response | |
| response to nutrient | |
| response to cytokine stimulus | |
| positive regulation of acute inflammatory response | |
| positive regulation vascular endothelial growth factor production | |
| positive regulation of cardiac muscle hypertrophy | |
| growth factor binding | |
| ciliary neurotrophic factor receptor binding | |
| interleukin-6 receptor binding | |
| interleukin-6 binding | |
| interleukin-11 binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| cytokine receptor activity | |
| interleukin-6 receptor activity | |
| interleukin-27 receptor activity | |
| interleukin-11 receptor activity | |
| oncostatin-M receptor activity | |
| ciliary neurotrophic factor receptor activity | |
| leukemia inhibitory factor receptor activity | |
| membrane | |
| extracellular region | |
| interleukin-6 receptor complex | |
| ciliary neurotrophic factor receptor complex | |
| external side of plasma membrane | |
| oncostatin-M receptor complex | |
| neuronal cell body membrane | |
| integral to membrane | |
| plasma membrane | |
| cell body | |
| dendrite | |
| neuronal cell body | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3572 |
|---|
| Hugo ID | 6021 |
|---|
| Human chromosome position | 5q11.2 |
|---|---|
| 5q11 |
| LocusLink ID | 3572 |
|---|---|
| 16195 | |
| 25205 |
| Alias | CD130 |
|---|---|
| GP130 | |
| CDW130 | |
| IL-6RB | |
| interleukin-6 receptor subunit beta | |
| CD130 antigen | |
| IL-6R subunit beta | |
| membrane glycoprotein 130 | |
| IL-6 receptor subunit beta | |
| membrane glycoprotein gp130 | |
| interleukin receptor beta chain | |
| oncostatin-M receptor subunit alpha | |
| gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form | |
| AA389424 | |
| BB405851 | |
| D13Ertd699e | |
| 5133400A03Rik | |
| IL-6R-beta | |
| interleukin-6 signal transducer | |
| Ac1055 | |
| interleukin IL6B_HUMAN | |
| interleukin IL6B | |
| interleukin IL6 receptor beta | |
| interleukin 6 signal transducer (gp130, oncostatin M receptor) | |
| Interleukin 6 signal transducer | |
| IL6ST nirs variant 3 | |
| interleukin IL6B_MOUSE | |
| IL6st | |
| interleukin IL6R beta | |
| interleukin IL6st | |
| interleukin IL6ST nirs variant 3 | |
| OTTHUMP00000122545 | |
| Interleukin-6 receptor beta chain | |
| AC-1055 | |
| interleukin-6 signal transducing molecule gp130 | |
| IL6R beta | |
| AC(1055) | |
| IL6B_MOUSE | |
| 5133400A03 | |
| AC 1055 | |
| DKFZp564F053 | |
| glycoprotein 130 | |
| gp130 transducer chain | |
| IL6B_HUMAN | |
| GP130-RAPS | |
| IL6 receptor beta | |
| IL6B | |
| DNA segment, Chr 13, ERATO Doi 699, expressed |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600694 |
|---|
| Unigene ID | Hs.532082 |
|---|---|
| Hs.706627 | |
| Mm.4364 | |
| Rn.12138 | |
| Hs.612730 |
| KEGG ID | hsa:3572 |
|---|---|
| mmu:16195 | |
| rno:25205 |
| Swiss-Prot Accession | P40189 |
|---|---|
| Q17RA0 | |
| Q00560 | |
| Q6PDI9 | |
| P40190 | |
| A0N0L4 | |
| Q5FC04 | |
| Q9UQ41 | |
| G5E8D2 | |
| O15281 | |
| Q13514 | |
| Q5FC02 | |
| Q5FC03 | |
| Q5FC05 | |
| Q5FC06 | |
| Q5FC07 | |
| Q3TDT5 | |
| Q3UQA0 | |
| Q7TQ89 |
| GO ID | 0004897 |
|---|---|
| 0005127 | |
| 0019838 | |
| 0019970 | |
| 0004921 | |
| 0045509 | |
| 0019981 | |
| 0004915 | |
| 0005138 | |
| 0004923 | |
| 0004924 | |
| 0042803 | |
| 0007259 | |
| 0070120 | |
| 0019221 | |
| 0005977 | |
| 0070106 | |
| 0070102 | |
| 0048861 | |
| 0070104 | |
| 0038165 | |
| 0042102 | |
| 0002675 | |
| 0002821 | |
| 0048711 | |
| 0010613 | |
| 0008284 | |
| 0045669 | |
| 0014911 | |
| 0042511 | |
| 0042517 | |
| 0010575 | |
| 0051481 | |
| 0008593 | |
| 0034097 | |
| 0007584 | |
| 0006642 | |
| 0070110 | |
| 0030425 | |
| 0009897 | |
| 0005576 | |
| 0005615 | |
| 0005896 | |
| 0043025 | |
| 0005900 | |
| 0005886 | |
| 0004896 | |
| 0046982 | |
| 0007165 | |
| 0044297 | |
| 0016021 | |
| 0016020 | |
| 0032809 | |
| 0046883 | |
| 0038154 | |
| 0045768 | |
| 0004872 | |
| 0005125 | |
| 0030307 |
| PIR ID | A36337 |
|---|---|
| I49699 |
| Swiss-Prot ID | IL6RB_HUMAN |
|---|---|
| IL6RB_MOUSE | |
| Q6PDI9_MOUSE | |
| Q7TQ89_RAT |
| Cell Localization | Cell membrane |
|---|---|
| Secreted | |
| Membrane | |
| Plasma membrane |
| IPI ID | IPI00297124 |
|---|---|
| IPI00554518 | |
| IPI00939624 | |
| IPI00120155 | |
| IPI00215135 | |
| IPI00749145 | |
| IPI00816609 | |
| IPI00554459 | |
| IPI00554478 | |
| IPI00554522 | |
| IPI00554499 | |
| IPI00554577 | |
| IPI00565057 |
| Mouse chromosome position | 13 67.0 cM |
|---|
| Rat chromosome position | 2q14-q16 |
|---|
| Homologene ID | 1645 |
|---|
| MGI ID | 96560 |
|---|
| RGD ID | 2903 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|