| URN | urn:agi-llid:3569 |
|---|---|
| Total Entities | 0 |
| Connectivity | 7745 |
| Name | Il6 |
| Description | interleukin 6 (interferon, beta 2) |
| Notes | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq] |
| Ariadne Ontology | Cytokine |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | receptor binding |
|---|---|
| growth factor activity | |
| cytokine activity | |
| interleukin-6 receptor binding |
| GO Cellular Component | extracellular region |
|---|---|
| interleukin-6 receptor complex | |
| external side of plasma membrane | |
| extracellular space |
| GO Biological Process | response to bacterium |
|---|---|
| defense response to protozoan | |
| response to yeast | |
| defense response to virus | |
| defense response to Gram-negative bacterium | |
| defense response to Gram-positive bacterium | |
| cell growth | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of MAPK cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of STAT protein import into nucleus | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| negative regulation of hormone secretion | |
| positive regulation of transmission of nerve impulse | |
| cell redox homeostasis | |
| regulation of cell proliferation | |
| cytokine-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| positive regulation of translation | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of DNA replication | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| negative regulation of gluconeogenesis | |
| negative regulation of chemokine biosynthetic process | |
| negative regulation of protein kinase activity | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of cell proliferation | |
| negative regulation of fat cell differentiation | |
| negative regulation of neuron death | |
| negative regulation of apoptotic process | |
| negative regulation of cytokine secretion | |
| positive regulation of cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of B cell activation | |
| positive regulation of T-helper 2 cell differentiation | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of osteoblast differentiation | |
| positive regulation of neuron differentiation | |
| positive regulation of immunoglobulin secretion | |
| positive regulation of protein import into nucleus, translocation | |
| regulation of cell shape | |
| regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| platelet activation | |
| T cell activation | |
| glucagon secretion | |
| muscle cell homeostasis | |
| monocyte chemotaxis | |
| cellular response to hydrogen peroxide | |
| neutrophil apoptotic process | |
| neuron projection development | |
| immune response | |
| neutrophil mediated immunity | |
| humoral immune response | |
| hepatic immune response | |
| epithelial cell proliferation involved in salivary gland morphogenesis | |
| response to drug | |
| response to calcium ion | |
| response to amino acid stimulus | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to peptidoglycan | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| response to insulin stimulus | |
| response to caffeine | |
| response to antibiotic | |
| response to heat | |
| response to cold | |
| response to wounding | |
| inflammatory response | |
| acute-phase response | |
| positive regulation of acute inflammatory response | |
| response to mechanical stimulus | |
| response to nutrient levels | |
| regulation of circadian sleep-wake cycle, non-REM sleep | |
| response to electrical stimulus | |
| negative regulation of lipid storage | |
| negative regulation of collagen biosynthetic process | |
| negative regulation of muscle organ development | |
| regulation of vascular endothelial growth factor production | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| regulation of angiogenesis | |
| positive regulation of gene expression | |
| aging | |
| branching involved in salivary gland morphogenesis | |
| endocrine pancreas development | |
| bone remodeling |
| Pathway | IL6R -> STAT signaling |
|---|---|
| IL6ST -> STAT5B signaling | |
| IL6R -> CEBP/ELK-SRF signaling | |
| ROS in Triggering Vascular Inflammation | |
| TGFB2-TGFBR2 Expression Targets | |
| TGFB1-TGFBR2 Expression Targets | |
| BMP2-BMPR2 Expression Targets | |
| BMP7-BMPR2/ACVR2 Expression Targets | |
| MSTN-ACVR2/BMPR Expression Targets | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| TLR3 Expression Targets | |
| TGFB2-TGFBR1 Expression Targets | |
| TGFB3-TGFBR1 Expression Targets | |
| DLL4 Expression Targets | |
| ADAM17 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/STAT Expression Targets | |
| NGF/AP-1/TP53/MYC Expression Targets | |
| NGF/CREB/CEBPB/MEF2A Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| CD40LG/STAT Expression Targets | |
| Fibrinogen Expression Targets | |
| CD21 Expression Targets | |
| CD19 Expression Targets | |
| IL13 Expression Targets | |
| IL21 Expression Targets | |
| IL15 Expression Targets | |
| IL6 Expression Targets | |
| IL7 Expression Targets | |
| IL2 Expression Targets | |
| IL5 Expression Targets | |
| IL11 Expression Targets | |
| IL3 Expression Targets | |
| LIF Expression Targets | |
| CTF1 Expression Targets | |
| OSM-IL6ST/LIFR Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| GH1-PRLR Expression Targets | |
| PRL-PRLR Expression Targets | |
| CSF3 Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| IFNG-IFNR Expression Targets | |
| OSM-OSMR Expression Targets | |
| Leptin/ELK-SRF Expression Targets | |
| Leptin/STAT Expression Targets | |
| CCL3 Expression Targets | |
| CCL5 Expression Targets | |
| CCL11 Expression Targets | |
| IL8 Expression Targets | |
| CXCL12 Expression Targets | |
| SST Expression Targets | |
| Dopamine/Gi Expression Targets | |
| Dronabinol/Anandamide Expression Targets | |
| S100B Expression Targets | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| PTPRC/BCL6 Expression Targets | |
| AREG/STAT Expression Targets | |
| AREG/AP-1 Expression Targets | |
| AREG/NFATC Expression Target | |
| FGF18/STAT Expression Targets | |
| CSF1/STAT Expression Targets | |
| KITLG/STAT Expression Targets | |
| Collagen/NF-kB Expression Targets | |
| IGF2/STAT Expression Targets | |
| CTGF/AP-1/CREB/MYC Expression Targets | |
| PGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| AREG/CREB/CREBBP Expression Targets | |
| AREG/FOXO3A Expression Target | |
| FGF18/AP-1/CREB Expression Targets | |
| CSF1/AP-1/CREB/CREBBP/MYC Expression Targets | |
| F2 -> AP-1/CREB/ELK-SRF/SP1 Expression Targets | |
| Thromboxane A2 Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| Serotonin/Gq Expression Targets | |
| Epinephrine/Gq Expression Targets | |
| Adenosine Expression Targets | |
| Prostaglandin F Expression Targets | |
| Glutamate/Gq Expression Targets | |
| GNRH1 Expression Targets | |
| Morphine Expression Targets | |
| S1P Expression Targets | |
| TAC1 Expression Targets | |
| PGE1 Expression Targets | |
| Epinephrine/Gs Expression Targets | |
| Noradrenaline/Gs Expression Targets | |
| VIP Expression Targets | |
| Dopamine/Gs Expression Targets | |
| GCG Expression Targets | |
| FSHR Expression Targets | |
| Serotonin/Gs Expression Targets | |
| Noreadrenaline/Gq Expression Targets | |
| IFNA1/Gq Expression Targets | |
| CXCL2 Expression Targets | |
| CXCL5 Expression Targets | |
| EDN1 Expression Targets | |
| EDN3 Expression Targets | |
| CD2 Expression Targets | |
| IL16/STAT Expression Targets | |
| IL16/NF-kB Expression Targets | |
| IL16/AP-1 Expression Targets | |
| IL16/ATF/CREB/CREBBP Expression Target | |
| CD8/NFATC Expression Targets | |
| CD8/AP-1 Expression Targets | |
| CD8/ATF/CREB/CREBBP Expression Targets | |
| CD80/STAT Expression Targets | |
| CD80/NF-kB Expression Targets | |
| CD80/AP-1 Expression Targets | |
| CD86/STAT Expression Targets | |
| CD86/NF-kB Expression Targets | |
| CD86/AP-1 Expression Targets | |
| CD86/ATF/CREB/CREBBP Expression Targets | |
| TCR/STAT Expression Targets | |
| TCR/AP-1 Expression Targets | |
| TCR/CREB/CREBBP/ATF Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| TCR/NF-kB Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1A Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| INHBA-ACVR2/BMPR Expression Targets | |
| NOTCH Expression Targets | |
| TGFB1-TGFBR1 Expression Targets | |
| TNF/NF-kB Expression Targets | |
| WNT5A Expression Targets | |
| PAF Expression Targets | |
| AGT/CREB Expression Targets | |
| AGT/STAT Expression Targets | |
| CSF2/STAT Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| KITLG/AP-1/CREB/CREBBP/MYC Expression Targets | |
| LPA Expression Targets | |
| PAF/Gq -> AP-1/ATF1/CREB/ERK-SRF Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TGFB1-ACVRL1 Expression Targets | |
| TGFB1-TGFBR1/AP-1 Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TNF/AP-1 Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| Interleukin-6 signaling pathway | |
| interleukin-6 signaling pathway |
| Group | Cytokine |
|---|---|
| response to bacterium | |
| defense response to protozoan | |
| response to yeast | |
| defense response to virus | |
| defense response to Gram-negative bacterium | |
| defense response to Gram-positive bacterium | |
| cell growth | |
| positive regulation of protein kinase B signaling cascade | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of MAPK cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of STAT protein import into nucleus | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| negative regulation of hormone secretion | |
| positive regulation of transmission of nerve impulse | |
| cell redox homeostasis | |
| regulation of cell proliferation | |
| cytokine-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| positive regulation of translation | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of nitric oxide biosynthetic process | |
| positive regulation of DNA replication | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of peptidyl-serine phosphorylation | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| negative regulation of gluconeogenesis | |
| negative regulation of chemokine biosynthetic process | |
| negative regulation of protein kinase activity | |
| positive regulation of sequence-specific DNA binding transcription factor activity | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of cell proliferation | |
| negative regulation of fat cell differentiation | |
| negative regulation of neuron death | |
| negative regulation of apoptotic process | |
| negative regulation of cytokine secretion | |
| positive regulation of cell proliferation | |
| positive regulation of epithelial cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of T cell proliferation | |
| positive regulation of B cell activation | |
| positive regulation of T-helper 2 cell differentiation | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of osteoblast differentiation | |
| positive regulation of neuron differentiation | |
| positive regulation of immunoglobulin secretion | |
| positive regulation of protein import into nucleus, translocation | |
| regulation of cell shape | |
| regulation of apoptotic process | |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| platelet activation | |
| T cell activation | |
| glucagon secretion | |
| muscle cell homeostasis | |
| monocyte chemotaxis | |
| cellular response to hydrogen peroxide | |
| neutrophil apoptotic process | |
| neuron projection development | |
| immune response | |
| neutrophil mediated immunity | |
| humoral immune response | |
| hepatic immune response | |
| epithelial cell proliferation involved in salivary gland morphogenesis | |
| response to drug | |
| response to calcium ion | |
| response to amino acid stimulus | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to peptidoglycan | |
| response to lipopolysaccharide | |
| response to glucocorticoid stimulus | |
| response to insulin stimulus | |
| response to caffeine | |
| response to antibiotic | |
| response to heat | |
| response to cold | |
| response to wounding | |
| inflammatory response | |
| acute-phase response | |
| positive regulation of acute inflammatory response | |
| response to mechanical stimulus | |
| response to nutrient levels | |
| regulation of circadian sleep-wake cycle, non-REM sleep | |
| response to electrical stimulus | |
| negative regulation of lipid storage | |
| negative regulation of collagen biosynthetic process | |
| negative regulation of muscle organ development | |
| regulation of vascular endothelial growth factor production | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| regulation of angiogenesis | |
| positive regulation of gene expression | |
| aging | |
| branching involved in salivary gland morphogenesis | |
| endocrine pancreas development | |
| bone remodeling | |
| receptor binding | |
| growth factor activity | |
| cytokine activity | |
| interleukin-6 receptor binding | |
| extracellular region | |
| interleukin-6 receptor complex | |
| external side of plasma membrane | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3569 |
|---|
| Hugo ID | 6018 |
|---|
| Human chromosome position | 7p21 |
|---|
| LocusLink ID | 3569 |
|---|---|
| 16193 | |
| 24498 |
| Alias | HGF |
|---|---|
| HSF | |
| BSF2 | |
| IL-6 | |
| IFNB2 | |
| interleukin-6 | |
| CDF | |
| BSF-2 | |
| IFN-beta-2 | |
| interferon beta-2 | |
| interleukin BSF-2 | |
| hybridoma growth factor | |
| CTL differentiation factor | |
| B-cell stimulatory factor 2 | |
| B-cell differentiation factor | |
| interleukin HP-1 | |
| B-cell hybridoma growth factor | |
| ILg6 | |
| Interleukin 6 (interferon, beta 2) | |
| interleukin IL6 | |
| interleukin IL6_HUMAN | |
| interleukin VI | |
| interlukin 6 | |
| OTTHUMP00000158544 | |
| OTTHUMP00000198490 | |
| interleukin 6 | |
| OTTHUMP00000198486 | |
| Interferon beta II | |
| B-cell stimulatory factor II | |
| IL6 | |
| IL6_HUMAN | |
| B cell stimulatory factor-2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147620 |
|---|---|
| 108010 | |
| 148000 | |
| 222100 | |
| 125853 | |
| 266600 | |
| 604302 | |
| 166710 |
| Unigene ID | Hs.654458 |
|---|---|
| Mm.1019 | |
| Rn.9873 |
| KEGG ID | hsa:3569 |
|---|---|
| mmu:16193 | |
| rno:24498 |
| Swiss-Prot Accession | B4DVM1 |
|---|---|
| P05231 | |
| Q75MH2 | |
| A2RTD1 | |
| P08505 | |
| P20607 | |
| Q3UCQ0 | |
| Q8BN26 | |
| Q9UCU2 | |
| Q9UCU3 | |
| Q9UCU4 | |
| Q8N6X1 | |
| Q0PMN1 | |
| Q3U8J8 |
| GO ID | 0005125 |
|---|---|
| 0008083 | |
| 0005138 | |
| 0042110 | |
| 0006953 | |
| 0007568 | |
| 0046849 | |
| 0060445 | |
| 0016049 | |
| 0045454 | |
| 0070301 | |
| 0019221 | |
| 0050829 | |
| 0050830 | |
| 0042832 | |
| 0051607 | |
| 0031018 | |
| 0060664 | |
| 0070091 | |
| 0002384 | |
| 0006959 | |
| 0006954 | |
| 0070102 | |
| 0002548 | |
| 0046716 | |
| 0043066 | |
| 0008285 | |
| 0045079 | |
| 0032966 | |
| 0043154 | |
| 0050710 | |
| 0045599 | |
| 0045721 | |
| 0046888 | |
| 0010888 | |
| 0048635 | |
| 0006469 | |
| 0031175 | |
| 0001781 | |
| 0002446 | |
| 0030168 | |
| 0050871 | |
| 0045740 | |
| 0070374 | |
| 0046427 | |
| 0043410 | |
| 0051092 | |
| 2000366 | |
| 0042102 | |
| 0045630 | |
| 0002675 | |
| 0008284 | |
| 0032722 | |
| 0050679 | |
| 0051024 | |
| 0032755 | |
| 0002690 | |
| 0045666 | |
| 0045429 | |
| 0045669 | |
| 0033138 | |
| 0050731 | |
| 0033160 | |
| 0051897 | |
| 0051091 | |
| 0048661 | |
| 0045944 | |
| 0045893 | |
| 0045727 | |
| 0051971 | |
| 0042517 | |
| 0045765 | |
| 0042981 | |
| 0008360 | |
| 0045188 | |
| 0010574 | |
| 0043200 | |
| 0046677 | |
| 0031000 | |
| 0051592 | |
| 0009409 | |
| 0042493 | |
| 0051602 | |
| 0051384 | |
| 0009408 | |
| 0032868 | |
| 0032496 | |
| 0009612 | |
| 0031667 | |
| 0032494 | |
| 0009897 | |
| 0005576 | |
| 0005615 | |
| 0005896 | |
| 0005102 | |
| 0006955 | |
| 1901215 | |
| 0010628 | |
| 0042127 | |
| 0009611 | |
| 0009617 | |
| 0034097 | |
| 0014070 | |
| 0001878 | |
| 0045768 | |
| 0043193 | |
| 0043526 | |
| 0051789 |
| PIR ID | A30531 |
|---|---|
| A32648 | |
| A34247 |
| Swiss-Prot ID | IL6_MOUSE |
|---|---|
| IL6_HUMAN | |
| IL6_RAT | |
| A2RTD1_MOUSE | |
| Q75MH2_HUMAN | |
| B4DVM1_HUMAN |
| Cell Localization | Secreted |
|---|---|
| Extracellular |
| IPI ID | IPI00133702 |
|---|---|
| IPI00007793 | |
| IPI00201260 | |
| IPI00878107 | |
| IPI00167115 | |
| IPI00878334 | |
| IPI00878660 | |
| IPI00877815 | |
| IPI00877634 |
| Mouse chromosome position | 5 17.0 cM |
|---|
| Rat chromosome position | 4q11 |
|---|
| Homologene ID | 502 |
|---|
| MGI ID | 96559 |
|---|
| RGD ID | 2901 |
|---|
| Primary Cell Localization | Extracellular |
|---|