| URN | urn:agi-llid:3570 |
|---|---|
| Total Entities | 0 |
| Connectivity | 778 |
| Name | Il6r |
| Description | interleukin 6 receptor |
| Notes | Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
| Ariadne Ontology | CytokineR |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | enzyme binding |
|---|---|
| interleukin-6 receptor binding | |
| ciliary neurotrophic factor binding | |
| interleukin-6 binding | |
| protein homodimerization activity | |
| cytokine receptor activity | |
| interleukin-6 receptor activity | |
| ciliary neurotrophic factor receptor activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| interleukin-6 receptor complex | |
| basolateral plasma membrane | |
| apical plasma membrane | |
| neuronal cell body membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| extracellular space |
| GO Biological Process | defense response to Gram-negative bacterium |
|---|---|
| defense response to Gram-positive bacterium | |
| cell growth | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of MAPK cascade | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| positive regulation of activation of Janus kinase activity | |
| cytokine-mediated signaling pathway | |
| ciliary neurotrophic factor-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of osteoblast differentiation | |
| regulation of apoptotic process | |
| monocyte chemotaxis | |
| neutrophil mediated immunity | |
| hepatic immune response | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| response to cAMP | |
| response to ethanol | |
| acute-phase response | |
| response to gamma radiation | |
| negative regulation of interleukin-8 production | |
| negative regulation of collagen biosynthetic process | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| endocrine pancreas development |
| Pathway | IL6R -> STAT signaling |
|---|---|
| IL6R -> CEBP/ELK-SRF signaling | |
| IL6 Expression Targets | |
| Interleukin-6 signaling pathway | |
| interleukin-6 signaling pathway |
| Group | CytokineR |
|---|---|
| defense response to Gram-negative bacterium | |
| defense response to Gram-positive bacterium | |
| cell growth | |
| positive regulation of JAK-STAT cascade | |
| positive regulation of MAPK cascade | |
| positive regulation of tyrosine phosphorylation of Stat3 protein | |
| positive regulation of activation of Janus kinase activity | |
| cytokine-mediated signaling pathway | |
| ciliary neurotrophic factor-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| positive regulation of peptidyl-tyrosine phosphorylation | |
| positive regulation of NF-kappaB transcription factor activity | |
| positive regulation of cell proliferation | |
| positive regulation of smooth muscle cell proliferation | |
| positive regulation of leukocyte chemotaxis | |
| positive regulation of osteoblast differentiation | |
| regulation of apoptotic process | |
| monocyte chemotaxis | |
| neutrophil mediated immunity | |
| hepatic immune response | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| response to glucocorticoid stimulus | |
| response to cAMP | |
| response to ethanol | |
| acute-phase response | |
| response to gamma radiation | |
| negative regulation of interleukin-8 production | |
| negative regulation of collagen biosynthetic process | |
| positive regulation of interleukin-6 production | |
| positive regulation of chemokine production | |
| endocrine pancreas development | |
| enzyme binding | |
| interleukin-6 receptor binding | |
| ciliary neurotrophic factor binding | |
| interleukin-6 binding | |
| protein homodimerization activity | |
| cytokine receptor activity | |
| interleukin-6 receptor activity | |
| ciliary neurotrophic factor receptor activity | |
| membrane | |
| extracellular region | |
| interleukin-6 receptor complex | |
| basolateral plasma membrane | |
| apical plasma membrane | |
| neuronal cell body membrane | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 3570 |
|---|
| Hugo ID | 6019 |
|---|
| Human chromosome position | 1q21 |
|---|
| LocusLink ID | 3570 |
|---|---|
| 16194 | |
| 24499 |
| Alias | IL6Q |
|---|---|
| gp80 | |
| CD126 | |
| IL6RA | |
| IL6RQ | |
| IL-6RA | |
| IL-6R-1 | |
| interleukin-6 receptor subunit alpha | |
| IL-6R 1 | |
| CD126 antigen | |
| membrane glycoprotein 80 | |
| IL-6 receptor subunit alpha | |
| Il6r | |
| IL-6R | |
| IL-6R-alpha | |
| IL-6R subunit alpha | |
| IL-6 receptor alpha chain | |
| IL6R1 | |
| interleukin 6 receptor, alpha | |
| interleukin IL6 receptor, alpha subunit | |
| interleukin IL-6R I | |
| interleukin IL6R alpha | |
| interleukin IL6R | |
| interleukin IL6 receptors | |
| interleukin IL6 receptor subunit gp80 | |
| interleukin IL6RA | |
| interleukin IL6 receptor gp80 subunit | |
| sIL-6R | |
| interleukin IL6A | |
| MGC104991 | |
| MGC30256 | |
| interleukin IL6 Receptor alpha | |
| PIR:I53394 | |
| interleukin IL6A_HUMAN | |
| sIL-6R gp80 | |
| sIL-6Rs | |
| Soluble interleukin-6 receptor | |
| Soluble interleukin-6 receptors | |
| OTTHUMP00000034320 | |
| interleukin IL-6R 1 | |
| interleukin IL6 receptor | |
| gp80 subunit IL6 receptor | |
| gp80 subunit IL6 receptors | |
| IL6 receptor | |
| IL6 receptor gp80 subunit | |
| IL6 receptor subunit gp80 | |
| IL6 receptors | |
| interleukin 6 receptor alpha subunit | |
| IL6 Receptor alpha | |
| IL6A | |
| IL-6R I | |
| IL6R alpha | |
| IL6A_HUMAN | |
| interleukin 6 receptor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 147880 |
|---|---|
| 614752 |
| Unigene ID | Hs.135087 |
|---|---|
| Mm.2856 | |
| Rn.1716 | |
| Hs.709210 |
| KEGG ID | hsa:3570 |
|---|---|
| mmu:16194 | |
| rno:24499 |
| Swiss-Prot Accession | A0N0L5 |
|---|---|
| P08887 | |
| P22272 | |
| Q3URV7 | |
| G3V8T6 | |
| P22273 | |
| A8KAE8 | |
| B2R6V4 | |
| Q16202 | |
| Q53EQ7 | |
| Q5FWG2 | |
| Q5VZ23 |
| GO ID | 0070119 |
|---|---|
| 0004897 | |
| 0019899 | |
| 0019981 | |
| 0004915 | |
| 0005138 | |
| 0042803 | |
| 0006953 | |
| 0016049 | |
| 0070120 | |
| 0019221 | |
| 0050829 | |
| 0050830 | |
| 0031018 | |
| 0002384 | |
| 0070102 | |
| 0002548 | |
| 0032966 | |
| 0032717 | |
| 0002446 | |
| 0043410 | |
| 0051092 | |
| 0010536 | |
| 0008284 | |
| 0032722 | |
| 0032755 | |
| 0002690 | |
| 0045669 | |
| 0050731 | |
| 0048661 | |
| 0042517 | |
| 0042981 | |
| 0051591 | |
| 0034097 | |
| 0045471 | |
| 0010332 | |
| 0051384 | |
| 0032496 | |
| 0043434 | |
| 0016324 | |
| 0016323 | |
| 0009986 | |
| 0005576 | |
| 0005615 | |
| 0005896 | |
| 0005886 | |
| 0004896 | |
| 0046427 | |
| 0016021 | |
| 0016020 | |
| 0032809 | |
| 0045768 | |
| 0004872 |
| PIR ID | A41242 |
|---|---|
| JL0144 | |
| JL0145 |
| Swiss-Prot ID | IL6RA_HUMAN |
|---|---|
| IL6RA_MOUSE | |
| Q3URV7_MOUSE | |
| A0N0L5_HUMAN | |
| A8KAE8_HUMAN |
| Cell Localization | Basolateral cell membrane |
|---|---|
| Secreted | |
| Membrane | |
| Plasma membrane |
| IPI ID | IPI00031171 |
|---|---|
| IPI00413309 | |
| IPI00126188 | |
| IPI00205182 | |
| IPI00206288 |
| Mouse chromosome position | 3 42.1 cM |
|---|
| Rat chromosome position | 2q34 |
|---|
| Homologene ID | 474 |
|---|
| MGI ID | 105304 |
|---|
| RGD ID | 2902 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|