| URN | urn:agi-llid:6655 |
|---|---|
| Total Entities | 0 |
| Connectivity | 19 |
| Name | Sos2 |
| Description | son of sevenless homolog 2 (Drosophila) |
| Notes | mRNA expression increases after chronic clozapine treatment in the prefrontal cortex; may play a role in synaptic function [RGD] |
| Ariadne Ontology | SOS |
|---|
| GO Molecular Function | protein heterodimerization activity |
|---|---|
| guanyl-nucleotide exchange factor activity | |
| Ras guanyl-nucleotide exchange factor activity | |
| Rho guanyl-nucleotide exchange factor activity | |
| phospholipid binding | |
| DNA binding |
| GO Cellular Component | protein complex |
|---|---|
| intracellular | |
| cytosol |
| GO Biological Process | regulation of small GTPase mediated signal transduction |
|---|---|
| positive regulation of small GTPase mediated signal transduction | |
| regulation of Rho protein signal transduction | |
| apoptotic signaling pathway | |
| small GTPase mediated signal transduction | |
| nerve growth factor receptor signaling pathway | |
| apoptotic process | |
| axon guidance | |
| regulation of catalytic activity |
| Pathway | Interleukin-6 signaling pathway |
|---|---|
| insulin signaling pathway | |
| altered insulin signaling pathway | |
| insulin signaling pathway | |
| insulin signaling pathway | |
| epidermal growth factor/neuregulin signaling pathway | |
| interleukin-6 signaling pathway |
| Group | SOS |
|---|---|
| regulation of small GTPase mediated signal transduction | |
| positive regulation of small GTPase mediated signal transduction | |
| regulation of Rho protein signal transduction | |
| apoptotic signaling pathway | |
| small GTPase mediated signal transduction | |
| nerve growth factor receptor signaling pathway | |
| apoptotic process | |
| axon guidance | |
| regulation of catalytic activity | |
| protein heterodimerization activity | |
| guanyl-nucleotide exchange factor activity | |
| Ras guanyl-nucleotide exchange factor activity | |
| Rho guanyl-nucleotide exchange factor activity | |
| phospholipid binding | |
| DNA binding | |
| protein complex | |
| intracellular | |
| cytosol |
| MedScan ID | 6655 |
|---|---|
| 85384 |
| Hugo ID | 11188 |
|---|
| Human chromosome position | 14q21 |
|---|
| LocusLink ID | 6655 |
|---|---|
| 20663 | |
| 85384 |
| Alias | son of sevenless homolog 2 |
|---|---|
| SOS-2 | |
| guanine nucleotide exchange factor | |
| guanine nucleotide releasing factor | |
| mSOS-2 | |
| Sos1 | |
| son of sevenless 1 | |
| Sos2 | |
| son of sevenless (Drosophilia) homolog II | |
| son of sevenless II | |
| son of sevenless homolog II | |
| son of sevenless homolog 2 (Drosophila) | |
| son of sevenless 2 | |
| LOC92225 | |
| LOC63378 | |
| LOC145448 | |
| LOC122776 | |
| FLJ25596 | |
| son of sevenless (Drosophilia) homolog 2 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601247 |
|---|
| Unigene ID | Hs.291533 |
|---|---|
| Mm.3770 | |
| Rn.4226 | |
| Rn.202149 |
| KEGG ID | hsa:6655 |
|---|---|
| mmu:20663 | |
| rno:85384 |
| Swiss-Prot Accession | Q07890 |
|---|---|
| Q02384 | |
| F1MAI3 | |
| D3DSB4 | |
| Q15503 | |
| Q17RN1 | |
| Q9Z1I1 |
| GO ID | 0003677 |
|---|---|
| 0005089 | |
| 0005085 | |
| 0005543 | |
| 0046982 | |
| 0006915 | |
| 0007411 | |
| 0048011 | |
| 0035023 | |
| 0051056 | |
| 0007264 | |
| 0005829 | |
| 0005088 | |
| 0051057 | |
| 0050790 | |
| 0005622 | |
| 0043234 | |
| 0008624 | |
| 0005515 | |
| 0006334 | |
| 0000786 | |
| 0005634 |
| Swiss-Prot ID | SOS2_HUMAN |
|---|
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00020134 |
|---|---|
| IPI00367392 |
| Mouse chromosome position | 12 30.0 cM |
|---|
| Rat chromosome position | 6q24 |
|---|
| Homologene ID | 38253 |
|---|
| MGI ID | 98355 |
|---|
| RGD ID | 620435 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|