| URN | urn:agi-llid:102 |
|---|---|
| Total Entities | 0 |
| Connectivity | 443 |
| Name | Adam10 |
| Description | ADAM metallopeptidase domain 10 |
| Notes | Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. |
| Ariadne Ontology | Secreted proteins |
|---|
| GO Molecular Function | receptor binding |
|---|---|
| integrin binding | |
| protein kinase binding | |
| SH2 domain binding | |
| SH3 domain binding | |
| protein homodimerization activity | |
| metal ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| endopeptidase activity | |
| metalloendopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| extracellular region | |
| Golgi-associated vesicle | |
| postsynaptic density | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| endomembrane system | |
| cytoplasm | |
| Golgi apparatus | |
| trans-Golgi network | |
| nucleus |
| GO Biological Process | cell-cell signaling |
|---|---|
| integrin-mediated signaling pathway | |
| Notch signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of cell adhesion | |
| positive regulation of cell proliferation | |
| positive regulation of cell migration | |
| positive regulation of T cell chemotaxis | |
| regulation of osteoclast differentiation | |
| monocyte activation | |
| Notch receptor processing | |
| protein phosphorylation | |
| response to tumor necrosis factor | |
| in utero embryonic development | |
| nucleocytoplasmic transport | |
| proteolysis | |
| membrane protein ectodomain proteolysis | |
| PMA-inducible membrane protein ectodomain proteolysis | |
| constitutive protein ectodomain proteolysis |
| Pathway | Interleukin-6 signaling pathway |
|---|---|
| interleukin-6 signaling pathway |
| Group | cell-cell signaling |
|---|---|
| integrin-mediated signaling pathway | |
| Notch signaling pathway | |
| epidermal growth factor receptor signaling pathway | |
| positive regulation of cell growth | |
| negative regulation of cell adhesion | |
| positive regulation of cell proliferation | |
| positive regulation of cell migration | |
| positive regulation of T cell chemotaxis | |
| regulation of osteoclast differentiation | |
| monocyte activation | |
| Notch receptor processing | |
| protein phosphorylation | |
| response to tumor necrosis factor | |
| in utero embryonic development | |
| nucleocytoplasmic transport | |
| proteolysis | |
| membrane protein ectodomain proteolysis | |
| PMA-inducible membrane protein ectodomain proteolysis | |
| constitutive protein ectodomain proteolysis | |
| receptor binding | |
| integrin binding | |
| protein kinase binding | |
| SH2 domain binding | |
| SH3 domain binding | |
| protein homodimerization activity | |
| metal ion binding | |
| zinc ion binding | |
| hydrolase activity | |
| peptidase activity | |
| metallopeptidase activity | |
| endopeptidase activity | |
| metalloendopeptidase activity | |
| membrane | |
| extracellular region | |
| Golgi-associated vesicle | |
| postsynaptic density | |
| integral to membrane | |
| plasma membrane | |
| cell surface | |
| endomembrane system | |
| cytoplasm | |
| Golgi apparatus | |
| trans-Golgi network | |
| nucleus | |
| Secreted proteins |
| MedScan ID | 102 |
|---|
| Hugo ID | 188 |
|---|
| Human chromosome position | 15q22 |
|---|---|
| 15q2 |
| LocusLink ID | 102 |
|---|---|
| 11487 | |
| 29650 |
| Alias | kuz |
|---|---|
| AD10 | |
| MADM | |
| CD156c | |
| HsT18717 | |
| disintegrin and metalloproteinase domain-containing protein 10 | |
| CDw156 | |
| ADAM 10 | |
| kuzbanian protein homolog | |
| mammalian disintegrin-metalloprotease | |
| a disintegrin and metalloprotease domain 10 | |
| a disintegrin and metalloproteinase domain 10 | |
| kuzbanian | |
| 1700031C13Rik | |
| RP24-68C7.1 | |
| a disintegrin and metalloprotease domain (ADAM) 10 | |
| a disintegrin and metallopeptidase domain 10 | |
| OTTMUSP00000044640 | |
| disintegrin and metalloproteinase domain 10 | |
| LOC300815 | |
| Myelin-associated disintegrin metalloprotease | |
| Myelin-associated disintegrin metalloproteinase | |
| OTTHUMP00000165066 | |
| disintegrin and metalloproteinase domain (ADAM) 10 | |
| disintegrin and metalloprotease domain (ADAM) 10 | |
| disintegrin and metalloprotease domain-containing protein 10 | |
| a disintegrin and metalloproteinase domain (ADAM) 10 | |
| ADAM metallopeptidase domain 10 | |
| ADAM10 | |
| ADAM10 endopeptidase | |
| disintegrin and metalloprotease domain 10 | |
| 1700031C13 | |
| disintegrin precursor | |
| RIKEN cDNA 1700031C13 gene | |
| Adam10s |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602192 |
|---|
| Unigene ID | Hs.578508 |
|---|---|
| Mm.3037 | |
| Rn.42924 |
| KEGG ID | hsa:102 |
|---|---|
| mmu:11487 | |
| rno:29650 |
| Swiss-Prot Accession | O14672 |
|---|---|
| O35598 | |
| Q6NZC0 | |
| Q10743 | |
| B8JJJ0 | |
| Q10742 | |
| Q92650 | |
| A0AV88 |
| EC Number | 3.4.24.81 |
|---|
| GO ID | 0017124 |
|---|---|
| 0004175 | |
| 0005178 | |
| 0004222 | |
| 0008237 | |
| 0042803 | |
| 0019901 | |
| 0005102 | |
| 0008270 | |
| 0007220 | |
| 0007219 | |
| 0051088 | |
| 0007267 | |
| 0051089 | |
| 0007173 | |
| 0001701 | |
| 0007229 | |
| 0006509 | |
| 0042117 | |
| 0007162 | |
| 0010820 | |
| 0030307 | |
| 0030335 | |
| 0008284 | |
| 0006468 | |
| 0034612 | |
| 0005794 | |
| 0005798 | |
| 0009986 | |
| 0005737 | |
| 0012505 | |
| 0016021 | |
| 0005634 | |
| 0005886 | |
| 0014069 | |
| 0042169 | |
| 0016787 | |
| 0046872 | |
| 0008233 | |
| 0006913 | |
| 0006508 | |
| 0005576 | |
| 0016020 | |
| 0005802 | |
| 0045670 | |
| 0005624 | |
| 0043526 | |
| 0005515 | |
| 0005578 |
| Swiss-Prot ID | ADA10_MOUSE |
|---|---|
| ADA10_HUMAN | |
| Q6NZC0_MOUSE | |
| B8JJJ0_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Cell membrane | |
| Endomembrane system |
| IPI ID | IPI00131881 |
|---|---|
| IPI00013897 | |
| IPI00923060 | |
| IPI00794448 | |
| IPI00793003 | |
| IPI00792351 | |
| IPI00789102 | |
| IPI00791687 | |
| IPI00878134 | |
| IPI00767395 | |
| IPI00211732 |
| Mouse chromosome position | 9 41.0 cM |
|---|
| Rat chromosome position | 8q24 |
|---|
| Homologene ID | 865 |
|---|
| MGI ID | 109548 |
|---|
| RGD ID | 2032 |
|---|