Elsevier Inc. Tocilizumab Adam17 Adam10 IL6st ---> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos2 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Sos1 --+> the extracellular signal-regulated Raf/Mek/Erk signaling pathway Grb2 Y759 IL6st --+> Jak-Stat signaling pathway IL6st --+> Jak(s) Jak(s) --+> Stat(s) Tocilizumab ---| sIl6r Stat(s) Jak(s) IL6st sIl6st ---| IL6st Tocilizumab ---| Il6r Il6 Sos2 Ptpn11 Il6r Jak-Stat signaling pathway the extracellular signal-regulated Raf/Mek/Erk signaling pathway sIl6r ---- Tocilizumab Il6r ---- Tocilizumab IL6st ---- sIl6r Il6 ---- sIl6r Sos1 IL6st ---- Ptpn11 Grb2 ---- Ptpn11 IL6st ---- Stat(s) sIl6st Adam17 ---> sIl6r sIl6r Adam10 ---> sIl6r sIl6r ---- sIl6st Jak(s) ---> IL6st IL6st ---- Jak(s) Il6r ---- IL6st Il6 ---- Il6r Il6 ---- IL6st Jak(s) ---> Ptpn11