| URN | urn:agi-llid:3588 |
|---|---|
| Connectivity | 23 |
| Name | Il10rb |
| Description | interleukin 10 receptor, beta |
| Notes | The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq] |
| Pathway | IL10R -> STAT signaling |
|---|---|
| IL22R -> STAT3 signaling | |
| Interleukin-10 signaling pathway |
| GO Molecular Function | interleukin-10 receptor activity |
|---|---|
| receptor activity |
| GO Cellular Component | plasma membrane |
|---|---|
| interleukin-28 receptor complex | |
| integral to membrane |
| GO Biological Process | immune response |
|---|---|
| blood coagulation | |
| signal transduction | |
| inflammatory response |
| Ariadne Ontology | CytokineR |
|---|
| Group | CytokineR |
|---|---|
| immune response | |
| blood coagulation | |
| signal transduction | |
| inflammatory response | |
| interleukin-10 receptor activity | |
| receptor activity | |
| plasma membrane | |
| interleukin-28 receptor complex | |
| integral to membrane |
| MedScan ID | 3588 |
|---|
| Hugo ID | 5965 |
|---|
| Human chromosome position | 21q22.1-q22.2 |
|---|
| LocusLink ID | 3588 |
|---|---|
| 16155 | |
| 304091 |
| Alias | CRFB4 |
|---|---|
| CRF2-4 | |
| D21S58 | |
| D21S66 | |
| CDW210B | |
| IL-10R2 | |
| interleukin-10 receptor subunit beta | |
| IL-10RB | |
| IL-10R subunit 2 | |
| OTTHUMP00000221101 | |
| IL-10R subunit beta | |
| IL-10 receptor subunit beta | |
| cytokine receptor class-II CRF2-4 | |
| interleukin-10 receptor subunit 2 | |
| cytokine receptor class-II member 4 | |
| cytokine receptor family 2 member 4 | |
| cytokine receptor family II, member 4 | |
| Il10r2 | |
| D21S58h | |
| AI528744 | |
| D16H21S58 | |
| 6620401D04Rik | |
| interleukin 10 receptor 2 | |
| RGD1560373 | |
| 6620401D04 | |
| CRF2 IV | |
| cytokine receptor class-II CRF2 IV | |
| cytokine receptor family II, member IV | |
| IL-10 receptor beta | |
| IL10R beta | |
| IL10RB | |
| IL-10R-B | |
| interleukin 10 receptor, beta | |
| interleukin IL10 receptor 2 | |
| interleukin IL-10 receptor beta | |
| interleukin IL10R beta | |
| interleukin IL10r2 | |
| interleukin IL10RB | |
| interleukin IL-10R-B | |
| PIR:G01418 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123889 |
|---|---|
| 610424 | |
| 612567 |
| Mouse chromosome position | 16 63.11 cM |
|---|
| GO ID | 0004920 |
|---|---|
| 0004872 | |
| 0007596 | |
| 0006955 | |
| 0006954 | |
| 0007165 | |
| 0016021 | |
| 0032002 | |
| 0005886 |
| Rat chromosome position | 11q11 |
|---|
| Swiss-Prot Accession | Q08334 |
|---|---|
| Q6ZVU9 | |
| Q8VHM7 | |
| Q3TU35 | |
| Q61190 | |
| Q8VHM8 | |
| Q9BUU4 |
| PIR ID | A47003 |
|---|---|
| JC6311 |
| Unigene ID | Hs.654593 |
|---|---|
| Mm.4154 | |
| Rn.22261 |
| KEGG ID | hsa:3588 |
|---|---|
| mmu:16155 | |
| rno:304091 |
| Swiss-Prot ID | I10R2_HUMAN |
|---|---|
| Q8VHM7_MOUSE |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00942985 |
|---|---|
| IPI00320815 | |
| IPI00646217 | |
| IPI00788962 | |
| IPI00880100 | |
| IPI00893917 | |
| IPI00892611 | |
| IPI00892772 | |
| IPI00881556 | |
| IPI00881787 | |
| IPI00880838 | |
| IPI00362923 | |
| IPI00763498 |
| Homologene ID | 523 |
|---|
| RGD ID | 1560373 |
|---|
| MGI ID | 109380 |
|---|