| URN | urn:agi-llid:3587 |
|---|---|
| Connectivity | 135 |
| Name | Il10ra |
| Description | interleukin 10 receptor, alpha |
| Notes | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq] |
| Pathway | IL10R -> STAT signaling |
|---|---|
| Interleukin-10 signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| interleukin-10 receptor activity | |
| receptor activity |
| GO Cellular Component | membrane |
|---|---|
| plasma membrane | |
| cytoplasm | |
| integral to membrane |
| GO Biological Process | blood coagulation |
|---|---|
| response to lipopolysaccharide |
| Ariadne Ontology | CytokineR |
|---|
| Group | CytokineR |
|---|---|
| blood coagulation | |
| response to lipopolysaccharide | |
| signal transducer activity | |
| interleukin-10 receptor activity | |
| receptor activity | |
| membrane | |
| plasma membrane | |
| cytoplasm | |
| integral to membrane |
| MedScan ID | 3587 |
|---|
| Hugo ID | 5964 |
|---|
| Human chromosome position | 11q23 |
|---|
| LocusLink ID | 3587 |
|---|---|
| 16154 | |
| 117539 |
| Alias | IL10R |
|---|---|
| CDW210A | |
| HIL-10R | |
| IL-10R1 | |
| interleukin-10 receptor subunit alpha | |
| IL-10RA | |
| IL-10R subunit 1 | |
| IL-10R subunit alpha | |
| IL-10 receptor subunit alpha | |
| interleukin-10 receptor subunit 1 | |
| interleukin-10 receptor alpha chain | |
| CDw210 | |
| mIL-10R | |
| AW553859 | |
| I10R | |
| I10R_HUMAN | |
| IL-10 receptor | |
| IL-10 receptor alpha | |
| IL10 receptors | |
| IL-10R I | |
| IL10RA | |
| IL-10R-A | |
| IL-10Ralpha | |
| interleukin 10 receptor, alpha | |
| interleukin 10 receptors | |
| interleukin IL10 receptor | |
| interleukin IL-10 receptor alpha | |
| interleukin IL10 receptors | |
| interleukin IL10R | |
| interleukin IL-10R I | |
| interleukin IL-10R1 | |
| interleukin IL10RA | |
| interleukin IL-10R-A | |
| interleukin IL-10Ralpha | |
| interleukin-10 receptor |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 146933 |
|---|
| Mouse chromosome position | 9 26.0 cM |
|---|
| GO ID | 0004920 |
|---|---|
| 0004872 | |
| 0004871 | |
| 0007596 | |
| 0032496 | |
| 0005737 | |
| 0016021 | |
| 0005886 | |
| 0016020 |
| Rat chromosome position | 8q22 |
|---|
| Swiss-Prot Accession | Q13651 |
|---|---|
| Q59F35 | |
| Q3U6I9 | |
| Q3UDL4 | |
| Q61727 | |
| Q3UDV8 | |
| Q3UE89 | |
| Q99ND6 | |
| A8K6I0 | |
| B0YJ27 |
| PIR ID | A49667 |
|---|---|
| I56215 |
| Unigene ID | Hs.504035 |
|---|---|
| Mm.379327 | |
| Rn.64632 |
| KEGG ID | hsa:3587 |
|---|---|
| mmu:16154 | |
| rno:117539 |
| Swiss-Prot ID | I10R1_MOUSE |
|---|---|
| I10R1_HUMAN | |
| Q3UDL4_MOUSE | |
| Q99ND6_RAT | |
| Q3U6I9_MOUSE | |
| A8K6I0_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00124801 |
|---|---|
| IPI00014417 | |
| IPI00198792 |
| Homologene ID | 1196 |
|---|
| RGD ID | 620138 |
|---|
| MGI ID | 96538 |
|---|