Protein Stat1

URN	urn:agi-llid:6772
Connectivity	939
Name	Stat1
Description	signal transducer and activator of transcription 1, 91kDa
Notes	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]

Pathway	HGFR -> STAT signaling
	EphrinR -> STAT signaling
	ALK -> STAT signaling
	InsulinR -> STAT signaling
	IGF1R -> STAT signaling
	ThrombopoietinR -> STAT signaling
	ErythropoietinR -> STAT signaling
	CSF3R -> STAT signaling
	IFNGR -> STAT signaling
	LeptinR -> STAT signaling
	CSF2R -> STAT signaling
	ProlactinR -> STAT signaling
	IFNAR -> STAT signaling
	GHR -> STAT signaling
	EGFR/ERBB -> STAT signaling
	FGFR3 -> STAT signaling
	FGFR1 -> STAT signaling
	CSF1R -> STAT signaling
	KIT -> STAT signaling
	PDGFR -> STAT signaling
	VEGFR -> STAT signaling
	IL10R -> STAT signaling
	IL12R -> STAT signaling
	IL13R -> STAT signaling
	IL15R -> STAT signaling
	IL21R -> STAT signaling
	IL2R -> STAT signaling
	IL31R -> STAT signaling
	IL3R -> STAT signaling
	IL5R -> STAT signaling
	IL6R -> STAT signaling
	IL7R -> STAT signaling
	IL9R -> STAT signaling
	TNFRSF1A -> STAT signaling
	ThrombinR -> STAT1 signaling
	CCR1 -> STAT signaling
	CCR2/5 -> STAT signaling
	CXCR4 -> STAT signaling
	AdrenergicRa -> STAT1 signaling
	CholecystokininR -> STAT signaling
	VasopressinR1 -> STAT signaling
	AngiotensinR -> STAT signaling
	VasopressinR2 -> STAT signaling
	CD2 -> STAT signaling
	T-cell receptor -> STAT signaling
	UrokinaseR -> STAT signaling
	Interleukin-10 signaling pathway

GO Molecular Function	signal transducer activity
	transcription factor activity
	DNA binding
	sequence-specific DNA binding
	calcium ion binding
	hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity

GO Biological Process	positive regulation of cell proliferation
	interspecies interaction between organisms
	response to bacterium
	response to virus
	blood circulation
	signal transduction
	JAK-STAT cascade
	I-kappaB kinase-NF-kappaB cascade
	regulation of transcription
	regulation of transcription, DNA-dependent
	positive regulation of smooth muscle cell proliferation
	induction of apoptosis
	activation of caspase activity
	transcription
	transcription from RNA polymerase II promoter
	tyrosine phosphorylation of STAT protein
	cellular response to insulin stimulus
	lipopolysaccharide-mediated signaling pathway
	cytokine-mediated signaling pathway
	response to mechanical stimulus
	response to drug
	response to nutrient
	response to organic cyclic substance
	response to cAMP
	response to cytokine stimulus
	response to hydrogen peroxide
	response to lipopolysaccharide
	response to exogenous dsRNA
	response to peptide hormone stimulus

Ariadne Ontology	STAT

Group	STAT
	positive regulation of cell proliferation
	interspecies interaction between organisms
	response to bacterium
	response to virus
	blood circulation
	signal transduction
	JAK-STAT cascade
	I-kappaB kinase-NF-kappaB cascade
	regulation of transcription
	regulation of transcription, DNA-dependent
	positive regulation of smooth muscle cell proliferation
	induction of apoptosis
	activation of caspase activity
	transcription
	transcription from RNA polymerase II promoter
	tyrosine phosphorylation of STAT protein
	cellular response to insulin stimulus
	lipopolysaccharide-mediated signaling pathway
	cytokine-mediated signaling pathway
	response to mechanical stimulus
	response to drug
	response to nutrient
	response to organic cyclic substance
	response to cAMP
	response to cytokine stimulus
	response to hydrogen peroxide
	response to lipopolysaccharide
	response to exogenous dsRNA
	response to peptide hormone stimulus
	signal transducer activity
	transcription factor activity
	DNA binding
	sequence-specific DNA binding
	calcium ion binding
	hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity
	cytoplasm
	nucleolus
	nucleus
	axon
	dendrite

MedScan ID	6772

Hugo ID	11362

Human chromosome position	2q32.2

Alias	ISGF-3
	STAT91
	DKFZp686B04100
	signal transducer and activator of transcription 1-alpha/beta
	OTTHUMP00000165046
	OTTHUMP00000205845
	transcription factor ISGF-3 components p91/p84
	signal transducer and activator of transcription-1
	AA408197
	2010005J02Rik
	signal transducer and activator of transcription 1
	91 kDa signal transducer and activator of transcription 1
	91 kDa signal transducer and activator of transcription I
	hornerin
	interferon-dependent positive-acting transcription factor ISGF-3
	OTTHUMP00000165047
	PIR:A46159
	signal transducer and activator of transcription 1, 91kD
	signal transducer and activator of transcription 1, 91kDa
	Signal transducer and activator of transcription I
	Stat I
	Stat1
	transcription factor components p91/p84
	transcription factor ISGF III
	transcription factor ISGF-3

OMIM ID	600555
	209950

Mouse chromosome position	1 25.9 cM

Rat chromosome position	9q31-q32

PIR ID	A46159

Cell Localization	Cytoplasm
	Nucleus

Homologene ID	21428

RGD ID	3771

MGI ID	103063