| URN | urn:agi-llid:6774 |
|---|---|
| Connectivity | 1561 |
| Name | Stat3 |
| Description | signal transducer and activator of transcription 3 |
| Notes | transcription factor that plays a role in induction of gene expression during acute phase response [RGD] |
| Pathway | HGFR -> STAT signaling |
|---|---|
| EphrinR -> STAT signaling | |
| AngiopoietinR -> STAT signaling | |
| ALK -> STAT signaling | |
| InsulinR -> STAT signaling | |
| IGF1R -> STAT signaling | |
| ICAM2 -> CTNNB/FOXO/STAT3 signaling | |
| PECAM -> STAT signaling | |
| ThrombopoietinR -> STAT signaling | |
| ErythropoietinR -> STAT signaling | |
| OncostatinR -> STAT3 signaling | |
| CSF3R -> STAT signaling | |
| CNTFR -> STAT3 signaling | |
| IFNGR -> STAT signaling | |
| LeptinR -> STAT signaling | |
| CSF2R -> STAT signaling | |
| ProlactinR -> STAT signaling | |
| IFNAR -> STAT signaling | |
| GHR -> STAT signaling | |
| EGFR/ERBB -> STAT signaling | |
| FGFR3 -> STAT signaling | |
| FGFR1 -> STAT signaling | |
| CSF1R -> STAT signaling | |
| KIT -> STAT signaling | |
| PDGFR -> STAT signaling | |
| VEGFR -> STAT signaling | |
| IL10R -> STAT signaling | |
| IL11R -> STAT3 signaling | |
| IL12R -> STAT signaling | |
| IL13R -> STAT signaling | |
| IL15R -> STAT signaling | |
| IL21R -> STAT signaling | |
| IL22R -> STAT3 signaling | |
| IL2R -> STAT signaling | |
| IL31R -> STAT signaling | |
| IL3R -> STAT signaling | |
| IL5R -> STAT signaling | |
| IL6R -> STAT signaling | |
| IL7R -> STAT signaling | |
| IL9R -> STAT signaling | |
| TNFRSF1A -> STAT signaling | |
| TNFRSF5 -> STAT signaling | |
| CCR1 -> STAT signaling | |
| CCR2/5 -> STAT signaling | |
| CXCR4 -> STAT signaling | |
| AdrenergicRa -> STAT3 signaling | |
| BradykininR -> STAT3 signaling | |
| CholecystokininR -> STAT signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| PTAFR -> STAT3 signaling | |
| SerotoninR2 -> STAT3 signaling | |
| VasopressinR1 -> STAT signaling | |
| AdrenergicRb -> STAT3 signaling | |
| AngiotensinR -> STAT signaling | |
| VasopressinR2 -> STAT signaling | |
| IL1R -> STAT3 signaling | |
| CD2 -> STAT signaling | |
| T-cell receptor -> STAT signaling | |
| leptin system pathway | |
| Interleukin-10 signaling pathway |
| GO Molecular Function | signal transducer activity |
|---|---|
| transcription activator activity | |
| transcription factor activity | |
| transcription factor binding | |
| DNA binding | |
| protein kinase binding | |
| sequence-specific DNA binding | |
| calcium ion binding | |
| hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| nucleolus | |
| nucleus |
| GO Biological Process | cellular component movement |
|---|---|
| interspecies interaction between organisms | |
| sexual reproduction | |
| nervous system development | |
| eye photoreceptor cell differentiation | |
| regulation of multicellular organism growth | |
| temperature homeostasis | |
| signal transduction | |
| JAK-STAT cascade | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| regulation of transcription | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| cellular response to hormone stimulus | |
| cytokine-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| response to organic substance | |
| response to drug | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| acute-phase response | |
| eating behavior | |
| glucose homeostasis |
| Ariadne Ontology | STAT |
|---|
| Group | STAT |
|---|---|
| cellular component movement | |
| interspecies interaction between organisms | |
| sexual reproduction | |
| nervous system development | |
| eye photoreceptor cell differentiation | |
| regulation of multicellular organism growth | |
| temperature homeostasis | |
| signal transduction | |
| JAK-STAT cascade | |
| JAK-STAT cascade involved in growth hormone signaling pathway | |
| regulation of transcription | |
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| transcription from RNA polymerase II promoter | |
| cellular response to hormone stimulus | |
| cytokine-mediated signaling pathway | |
| interleukin-6-mediated signaling pathway | |
| response to organic substance | |
| response to drug | |
| response to organic cyclic substance | |
| response to ethanol | |
| response to cytokine stimulus | |
| response to peptide hormone stimulus | |
| response to estradiol stimulus | |
| acute-phase response | |
| eating behavior | |
| glucose homeostasis | |
| signal transducer activity | |
| transcription activator activity | |
| transcription factor activity | |
| transcription factor binding | |
| DNA binding | |
| protein kinase binding | |
| sequence-specific DNA binding | |
| calcium ion binding | |
| hematopoietin-interferon-class (D200-domain) cytokine receptor signal transducer activity | |
| plasma membrane | |
| cytoplasm | |
| nucleolus | |
| nucleus |
| MedScan ID | 6774 |
|---|
| Hugo ID | 11364 |
|---|
| Human chromosome position | 17q21.31 |
|---|
| LocusLink ID | 6774 |
|---|---|
| 20848 | |
| 25125 | |
| 68733 | |
| 104593 | |
| 114129 | |
| 508541 | |
| 282085 | |
| 30767 | |
| 323957 | |
| 334563 | |
| 793847 |
| Alias | APRF |
|---|---|
| HIES | |
| FLJ20882 | |
| MGC16063 | |
| signal transducer and activator of transcription 3 | |
| DNA-binding protein APRF | |
| acute-phase response factor | |
| AW109958 | |
| 1110034C02Rik | |
| RP23-279L23.5 | |
| OTTMUSP00000002052 | |
| OTTMUSP00000002053 | |
| OTTMUSP00000045315 | |
| OTTMUSP00000045316 | |
| acute phase response factor | |
| MGC93551 | |
| 1110034C02 | |
| Hyper-IgE syndrome gene | |
| Hyper-IgE syndrome protein | |
| signal transducer and activator of transcription 3 (acute-phase response fa | |
| signal transducer and activator of transcription 3 (acute-phase response factor) | |
| signal transducer and activator of transcription 3 isoform 1 | |
| signal transducer and activator of transcription 3 isoform 2 | |
| signal transducer and activator of transcription 3 isoform I | |
| signal transducer and activator of transcription 3 isoform II | |
| Signal transducer and activator of transcription III | |
| Stat3 | |
| Acute-phase response factor | |
| RIKEN cDNA 1110034C02 gene | |
| hypothetical protein MGC16063 | |
| fc15d02 | |
| wu:fc15d02 | |
| fl59g06 | |
| wu:fl59g06 | |
| LOC793847 | |
| chromosome | |
| scaffold | |
| similar to Stat3 protein |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 102582 |
|---|---|
| 147060 |
| Mouse chromosome position | 11 60.5 cM |
|---|
| GO ID | 0003677 |
|---|---|
| 0005509 | |
| 0005062 | |
| 0019901 | |
| 0043565 | |
| 0004871 | |
| 0016563 | |
| 0003700 | |
| 0008134 | |
| 0007259 | |
| 0060397 | |
| 0006953 | |
| 0006928 | |
| 0032870 | |
| 0019221 | |
| 0042755 | |
| 0001754 | |
| 0042593 | |
| 0070102 | |
| 0044419 | |
| 0000122 | |
| 0007399 | |
| 0045944 | |
| 0040014 | |
| 0045449 | |
| 0006357 | |
| 0034097 | |
| 0042493 | |
| 0032355 | |
| 0045471 | |
| 0014070 | |
| 0043434 | |
| 0019953 | |
| 0007165 | |
| 0001659 | |
| 0005737 | |
| 0005730 | |
| 0005634 | |
| 0005886 | |
| 0006355 | |
| 0006350 | |
| 0006366 | |
| 0010033 | |
| 0005515 | |
| 0046983 | |
| 0007242 |
| Rat chromosome position | 10q32.1 |
|---|
| Swiss-Prot Accession | P40763 |
|---|---|
| Q9BXH2 | |
| P42227 | |
| Q6GU23 | |
| Q3U5Q4 | |
| Q3U6S9 | |
| Q3ULI4 | |
| Q8CFJ6 | |
| Q99ML3 | |
| P52631 | |
| A2A5D1 | |
| B7ZC17 | |
| O14916 | |
| Q9BW54 | |
| Q8N2X9 |
| PIR ID | I49508 |
|---|---|
| A54444 |
| Unigene ID | Hs.463059 |
|---|---|
| Mm.249934 | |
| Rn.10247 | |
| Mm.277403 | |
| Hs.643543 | |
| Hs.567649 | |
| Bt.15334 |
| KEGG ID | hsa:6774 |
|---|---|
| mmu:20848 | |
| rno:25125 |
| Swiss-Prot ID | STAT3_MOUSE |
|---|---|
| STAT3_RAT | |
| STAT3_HUMAN | |
| Q6GU23_MOUSE | |
| A2A5D1_MOUSE | |
| B7ZC17_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00227814 |
|---|---|
| IPI00228955 | |
| IPI00753792 | |
| IPI00208224 | |
| IPI00306436 | |
| IPI00784414 | |
| IPI00412752 |
| Homologene ID | 7960 |
|---|
| RGD ID | 3772 |
|---|
| MGI ID | 103038 |
|---|---|
| 1915983 | |
| 2144497 |
| Microarray ID | 99099_at |
|---|---|
| 99100_at | |
| 208992_s_at |
| FunctionalClass | calcium ion binding |
|---|---|
| hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer | |
| signal transducer | |
| transcription factor | |
| transcription factor binding | |
| DNA binding | |
| protein binding | |
| protein dimerization | |
| transcriptional activator | |
| transcription activator |
| Mus musculus Chromosome position | 11 60.5 cM |
|---|---|
| 11 |
| Source | Curated |
|---|---|
| ResNet | |
| GO component | |
| RGD modified |
| KEGG pathway | Jak-STAT signaling pathway |
|---|
| Homo sapiens Chromosome position | 17q21.31 |
|---|
| Bos taurus Chromosome position | 19 |
|---|
| Danio rerio Chromosome position | LG 3 |
|---|
| LocatorString | pmquery:egfr+transactivation |
|---|
| Rattus norvegicus Chromosome position | 10q32.1 |
|---|