Ariadne Genomics Inc. P-Tyr1 P-Tyr2 Jak1 Stat3 Jak-Stat signaling pathway Stat1 Il10ra ---- Stat1 Il10 P-Tyr2 ---- Stat3 Il10ra Il10 ---- Il10ra Il10rb --+> Tyk2 Tyk2 Il10ra --+> Jak1 Tyk2 ---> Il10ra Il10ra ---- Jak1 Il10 --+> Stat3 Jak1 ---> Il10ra Il10 --+> Stat1 Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---> Th1 cell: Th2 cell responses; anti-inflammatory effects Il10 ---- Il10rb Il10rb Il10rb ---- Tyk2