| URN | urn:agi-llid:6714 |
|---|---|
| Connectivity | 2060 |
| Name | Src |
| Description | Rous sarcoma oncogene |
| Notes | mediates growth effects of both the precursor and fully processed forms of gastrins on rat intestinal epithelial cells [RGD] |
| Pathway | FGFR -> AP-1/CREB/CREBBP/ELK-SRF/MYC signaling |
|---|---|
| PDGFR -> AP-1/MYC signaling | |
| VEGFR -> AP-1/CREB/MYC signaling | |
| HGFR -> AP-1/CREB/MYC signaling | |
| AngiopoietinR -> AP-1 signaling | |
| ErythropoietinR -> AP-1/CREB/MYC signaling | |
| ThrombopoietinR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> AP-1/CREB/ELK-SRF/MYC signaling | |
| EGFR -> NCOR2 signaling | |
| HGFR -> STAT signaling | |
| NTRK -> AP-1/CREB/ELK-SRF/MYC/SMAD3/TP53 signaling | |
| NTRK -> FOXO/MYCN signaling | |
| GDNF -> HSF1 signaling | |
| IGF1R -> MEF/MYOD/MYOG signaling | |
| IGF1R -> ELK-SRF/HIF1A/MYC/SREBF signaling | |
| FibronectinR -> AP-1/ELK-SRF/SREBF signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| PECAM -> STAT signaling | |
| EGFR -> CTNND signaling | |
| EGFR/ERBB -> STAT signaling | |
| EGFR -> AP-1/ATF2 signaling | |
| EGFR/ERBB2 -> CTNNB signaling | |
| EGFR/ERBB2 -> HIF1A signaling | |
| EGFR/ERBB3 -> MEF/MYOD/NFATC/MYOG signaling | |
| EGFR/ERBB2 -> TP53 signaling | |
| FGFR1 -> STAT signaling | |
| CSF1R -> STAT signaling | |
| KIT -> MITF signaling | |
| PDGFR -> STAT signaling | |
| VEGFR -> CTNNB signaling | |
| VEGFR -> NFATC signaling | |
| VEGFR -> ATF/CREB/ELK-SRF signaling | |
| VEGFR -> CTNND signaling | |
| VEGFR -> STAT signaling | |
| IL6ST -> STAT5B signaling | |
| TNFRSF5/13B -> NFATC1 signaling | |
| ThrombinR -> AP-1/CREB/ELK-SRF/SP1 signaling | |
| ThrombinR -> NF-kB signaling | |
| ThrombinR -> STAT1 signaling | |
| CholinergicRm -> CREB/ELK-SRF signaling | |
| DopamineR2 -> AP-1/CREB/ELK-SRF signaling | |
| DopamineR2 -> NF-kB signaling | |
| AdenosineR -> NF-kB signaling | |
| GRM1/5 -> CREB signaling | |
| OpioidR -> CREB/ELK-SRF/STAT3 signaling | |
| VasopressinR1 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR1 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR1 -> STAT signaling | |
| AdrenergicRb -> CREB signaling | |
| AdrenergicRb -> STAT3 signaling | |
| VasopressinR2 -> CREB/ELK-SRF/AP-1/EGR signaling | |
| VasopressinR2 -> MEF/MYOD/NFATC/MYOG signaling | |
| VasopressinR2 -> STAT signaling | |
| T-cell receptor -> ATF/CREB signaling | |
| scatter factor-hepatocyte growth factor signaling pathway | |
| estrogen signaling pathway |
| GO Molecular Function | nucleotide binding |
|---|---|
| transferase activity | |
| protein C-terminus binding | |
| protein domain specific binding | |
| protein complex binding | |
| cell adhesion molecule binding | |
| receptor binding | |
| SH3-SH2 adaptor activity | |
| SH2 domain binding | |
| insulin receptor binding | |
| integrin binding | |
| protein kinase binding | |
| protein kinase C binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity |
| GO Cellular Component | postsynaptic density |
|---|---|
| plasma membrane | |
| cytosol | |
| synaptosome | |
| caveola |
| GO Biological Process | cell proliferation |
|---|---|
| interspecies interaction between organisms | |
| response to stress | |
| response to virus | |
| forebrain development | |
| uterus development | |
| branching involved in mammary gland duct morphogenesis | |
| positive regulation of cytokine secretion | |
| regulation of bone resorption | |
| regulation of vascular permeability | |
| oogenesis | |
| transcytosis | |
| signal transduction | |
| positive regulation of cell adhesion | |
| cell-cell adhesion | |
| positive regulation of intracellular protein kinase cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of insulin receptor signaling pathway | |
| intracellular protein kinase cascade | |
| Ras protein signal transduction | |
| positive regulation of glucose metabolic process | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of apoptosis | |
| cell migration | |
| protein amino acid phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| signal complex assembly | |
| cellular response to protein stimulus | |
| cellular response to hypoxia | |
| cellular response to fatty acid | |
| cellular response to insulin stimulus | |
| cellular response to lipopolysaccharide | |
| response to mechanical stimulus | |
| response to electrical stimulus | |
| response to drug | |
| response to acid | |
| response to hydrogen peroxide | |
| response to interleukin-1 | |
| response to fatty acid | |
| response to mineralocorticoid stimulus | |
| response to nutrient levels | |
| regulation of estrogen receptor signaling pathway | |
| positive regulation of protein transport | |
| positive regulation of gene expression | |
| positive regulation of integrin activation | |
| epidermal growth factor receptor signaling pathway | |
| platelet-derived growth factor receptor signaling pathway | |
| nerve growth factor receptor signaling pathway |
| Ariadne Ontology | Src |
|---|---|
| Oncogenes |
| Group | Src |
|---|---|
| Oncogenes | |
| cell proliferation | |
| interspecies interaction between organisms | |
| response to stress | |
| response to virus | |
| forebrain development | |
| uterus development | |
| branching involved in mammary gland duct morphogenesis | |
| positive regulation of cytokine secretion | |
| regulation of bone resorption | |
| regulation of vascular permeability | |
| oogenesis | |
| transcytosis | |
| signal transduction | |
| positive regulation of cell adhesion | |
| cell-cell adhesion | |
| positive regulation of intracellular protein kinase cascade | |
| positive regulation of ERK1 and ERK2 cascade | |
| positive regulation of insulin receptor signaling pathway | |
| intracellular protein kinase cascade | |
| Ras protein signal transduction | |
| positive regulation of glucose metabolic process | |
| positive regulation of smooth muscle cell migration | |
| positive regulation of apoptosis | |
| cell migration | |
| protein amino acid phosphorylation | |
| peptidyl-tyrosine phosphorylation | |
| signal complex assembly | |
| cellular response to protein stimulus | |
| cellular response to hypoxia | |
| cellular response to fatty acid | |
| cellular response to insulin stimulus | |
| cellular response to lipopolysaccharide | |
| response to mechanical stimulus | |
| response to electrical stimulus | |
| response to drug | |
| response to acid | |
| response to hydrogen peroxide | |
| response to interleukin-1 | |
| response to fatty acid | |
| response to mineralocorticoid stimulus | |
| response to nutrient levels | |
| regulation of estrogen receptor signaling pathway | |
| positive regulation of protein transport | |
| positive regulation of gene expression | |
| positive regulation of integrin activation | |
| epidermal growth factor receptor signaling pathway | |
| platelet-derived growth factor receptor signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| nucleotide binding | |
| transferase activity | |
| protein C-terminus binding | |
| protein domain specific binding | |
| protein complex binding | |
| cell adhesion molecule binding | |
| receptor binding | |
| SH3-SH2 adaptor activity | |
| SH2 domain binding | |
| insulin receptor binding | |
| integrin binding | |
| protein kinase binding | |
| protein kinase C binding | |
| ATP binding | |
| kinase activity | |
| protein kinase activity | |
| protein tyrosine kinase activity | |
| non-membrane spanning protein tyrosine kinase activity | |
| postsynaptic density | |
| plasma membrane | |
| cytosol | |
| synaptosome | |
| caveola |
| MedScan ID | 6714 |
|---|
| Hugo ID | 11283 |
|---|
| Human chromosome position | 20q12-q13 |
|---|
| LocusLink ID | 6714 |
|---|---|
| 20779 | |
| 83805 | |
| 99351 |
| Alias | ASV |
|---|---|
| SRC1 | |
| c-SRC | |
| p60-Src | |
| RP5-823N20.1 | |
| proto-oncogene tyrosine-protein kinase Src | |
| OTTHUMP00000174476 | |
| OTTHUMP00000174477 | |
| OTTHUMP00000174478 | |
| proto-oncogene c-Src | |
| tyrosine kinase pp60c-src | |
| tyrosine-protein kinase SRC-1 | |
| protooncogene SRC, Rous sarcoma | |
| AW259666 | |
| pp60c-src | |
| RP23-169M4.1 | |
| neuronal proto-oncogene tyrosine-protein kinase Src | |
| OTTMUSP00000017316 | |
| OTTMUSP00000019027 | |
| OTTMUSP00000019028 | |
| OTTMUSP00000019029 | |
| Rous sarcoma oncogene | |
| tyrosine protein kinase c-src | |
| tyrosine protein kinase pp60-c-src | |
| c-Src tyrosine kinase | |
| p60c-src | |
| protooncogene src | |
| Schmidt-Ruppin A-2 viral oncogene homolog | |
| Src | |
| SRC I | |
| Src protein kinase | |
| Src protein tyrosine kinase | |
| Src PTK | |
| Src tyrosine kinase | |
| SRC-1 kinase | |
| tyrosine kinase SRC-1 | |
| v-Src | |
| v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | |
| v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog | |
| v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | |
| expressed sequence AW259666 | |
| Schmidt-Ruppin A-2) viral oncogene homolog | |
| SRC SH2-domain | |
| SRC SH3-domain | |
| tyrosine protein kinase SRC-1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 190090 |
|---|
| Mouse chromosome position | 2 89.0 cM |
|---|
| GO ID | 0005524 |
|---|---|
| 0042169 | |
| 0005070 | |
| 0005178 | |
| 0016301 | |
| 0004715 | |
| 0000166 | |
| 0004672 | |
| 0004713 | |
| 0016740 | |
| 0007265 | |
| 0044419 | |
| 0007243 | |
| 0033625 | |
| 0006468 | |
| 0045124 | |
| 0043114 | |
| 0070555 | |
| 0007172 | |
| 0007165 | |
| 0005901 | |
| 0005829 | |
| 0005886 | |
| 0050839 | |
| 0005158 | |
| 0008022 | |
| 0032403 | |
| 0019904 | |
| 0005080 | |
| 0019901 | |
| 0005102 | |
| 0060444 | |
| 0016477 | |
| 0008283 | |
| 0030900 | |
| 0048011 | |
| 0048477 | |
| 0018108 | |
| 0070374 | |
| 0043065 | |
| 0045785 | |
| 0050715 | |
| 0010628 | |
| 0010907 | |
| 0046628 | |
| 0010740 | |
| 0051222 | |
| 0014911 | |
| 0033146 | |
| 0045056 | |
| 0060065 | |
| 0014069 | |
| 0019717 | |
| 0016337 | |
| 0071398 | |
| 0071456 | |
| 0032869 | |
| 0071222 | |
| 0071445 | |
| 0007173 | |
| 0048008 | |
| 0001101 | |
| 0042493 | |
| 0051602 | |
| 0070542 | |
| 0042542 | |
| 0009612 | |
| 0051385 | |
| 0031667 | |
| 0006950 | |
| 0009615 | |
| 0005515 | |
| 0051726 | |
| 0005622 | |
| 0016021 | |
| 0016020 | |
| 0004674 | |
| 0000074 | |
| 0004872 | |
| 0007242 | |
| 0050875 |
| Rat chromosome position | 3q42 |
|---|
| Swiss-Prot Accession | P12931 |
|---|---|
| Q71UK5 | |
| Q9H7V3 | |
| P05480 | |
| Q80XU2 | |
| Q2M4I4 | |
| Q3UKD6 | |
| Q9JJ10 | |
| Q45QJ2 | |
| Q9WUD9 | |
| Q76P87 | |
| Q86VB9 | |
| Q9H5A8 |
| PIR ID | A26891 |
|---|---|
| A43610 |
| Unigene ID | Hs.195659 |
|---|---|
| Mm.22845 | |
| Rn.112600 |
| KEGG ID | hsa:6714 |
|---|---|
| mmu:20779 | |
| rno:83805 |
| EC Number | 2.7.10.2 |
|---|---|
| 2.7.10.1 | |
| 2.7.1.112 |
| Swiss-Prot ID | SRC_HUMAN |
|---|---|
| SRC_MOUSE | |
| Q9JJ10_RAT | |
| Q2M4I4_MOUSE | |
| Q80XU2_MOUSE |
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00328867 |
|---|---|
| IPI00641230 | |
| IPI00222801 | |
| IPI00200886 | |
| IPI00719950 | |
| IPI00620622 |
| Homologene ID | 21120 |
|---|
| RGD ID | 620795 |
|---|
| MGI ID | 98397 |
|---|---|
| 2139334 |
| Source | Curated |
|---|