Protein Esr2

URN	urn:agi-llid:2100
Connectivity	654
Name	Esr2
Description	estrogen receptor 2 (ER beta)
Notes	This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq]

Pathway	estrogen signaling pathway
	tamoxifen pharmacodynamics pathway

GO Molecular Function	transcription regulator activity
	hormone binding
	lipid binding
	transcription factor activity
	steroid binding
	DNA binding
	receptor antagonist activity
	transcription coactivator activity
	sequence-specific DNA binding
	metal ion binding
	zinc ion binding
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	estrogen receptor activity

GO Biological Process	negative regulation of cell proliferation
	regulation of cell proliferation
	cell-cell signaling
	epithelial cell maturation involved in prostate gland development
	prostate gland epithelium morphogenesis
	vagina development
	uterus development
	brain development
	learning or memory
	behavioral fear response
	signal transduction
	negative regulation of cell growth
	negative regulation of androgen receptor signaling pathway
	regulation of transcription
	positive regulation of gene-specific transcription
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	negative regulation of epithelial cell proliferation
	positive regulation of apoptosis
	positive regulation of survival gene product expression
	neuroprotection
	neuron migration
	transcription
	negative regulation of behavior
	response to testosterone stimulus
	estrogen receptor signaling pathway
	ovarian follicle development

Ariadne Ontology	Estrogen-like

Group	Estrogen-like
	transcription regulator activity
	negative regulation of cell proliferation
	regulation of cell proliferation
	cell-cell signaling
	epithelial cell maturation involved in prostate gland development
	prostate gland epithelium morphogenesis
	vagina development
	uterus development
	brain development
	learning or memory
	behavioral fear response
	signal transduction
	negative regulation of cell growth
	negative regulation of androgen receptor signaling pathway
	regulation of transcription
	positive regulation of gene-specific transcription
	positive regulation of transcription from RNA polymerase II promoter
	regulation of transcription, DNA-dependent
	negative regulation of epithelial cell proliferation
	positive regulation of apoptosis
	positive regulation of survival gene product expression
	neuroprotection
	neuron migration
	transcription
	negative regulation of behavior
	response to testosterone stimulus
	estrogen receptor signaling pathway
	ovarian follicle development
	hormone binding
	lipid binding
	transcription factor activity
	steroid binding
	DNA binding
	receptor antagonist activity
	transcription coactivator activity
	sequence-specific DNA binding
	metal ion binding
	zinc ion binding
	receptor activity
	ligand-dependent nuclear receptor activity
	steroid hormone receptor activity
	estrogen receptor activity
	perikaryon
	neuron projection
	cytoplasm
	mitochondrion
	nucleus

MedScan ID	2100

Hugo ID	3468

Human chromosome position	14q23.2

Alias	Erb
	ESRB
	ESTRB
	NR3A2
	ER-BETA
	ESR-BETA
	estrogen receptor beta
	estrogen receptor beta 4
	nuclear receptor subfamily 3 group A member 2
	ER[b]
	ERbeta
	ER beta
	OTTMUSP00000023299
	OTTMUSP00000023324
	oestrogen receptor beta
	Erb2
	estrogen receptor 2 beta
	5 P 152
	5P(152)
	5P-152
	Esr2
	ESR2_HUMAN
	estradiol receptor beta
	estrogen receptor 2
	estrogen receptor 2 (beta)
	estrogen receptor 2 (ER beta)
	estrogen receptor II
	LOC440183
	membrane ERbeta
	membrane estrogen receptor beta
	membrane-bound ERbeta
	membrane-bound estrogen receptor beta
	mERbeta
	mER-beta
	oestrogen receptor 2
	oestrogen receptor 2 (beta)
	oestrogen receptor 2 (er beta)
	oestrogen receptor II

OMIM ID	601663

Mouse chromosome position	12 33.0 cM

Rat chromosome position	6q24

Cell Localization	Nucleus

Homologene ID	1100

RGD ID	2582

MGI ID	109392