| URN | urn:agi-llid:4792 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1549 |
| Name | Nfkbia |
| Description | nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha |
| Notes | inhibitor of NF-kappa-B; binds NF kappa B and retains it in the cytoplasm [RGD] |
| Ariadne Ontology | NFKBI |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | heat shock protein binding |
|---|---|
| protein complex binding | |
| transcription factor binding | |
| enzyme binding | |
| NF-kappaB binding | |
| ubiquitin protein ligase binding | |
| nuclear localization sequence binding |
| GO Cellular Component | protein complex |
|---|---|
| I-kappaB-NF-kappaB complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | virus-host interaction |
|---|---|
| negative regulation of Notch signaling pathway | |
| regulation of NF-kappaB import into nucleus | |
| cytoplasmic sequestering of NF-kappaB | |
| regulation of cell proliferation | |
| nucleotide-binding oligomerization domain containing 2 signaling pathway | |
| nucleotide-binding oligomerization domain containing 1 signaling pathway | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| lipopolysaccharide-mediated signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| negative regulation of myeloid cell differentiation | |
| negative regulation of macrophage derived foam cell differentiation | |
| cytoplasmic sequestering of transcription factor | |
| negative regulation of apoptotic process | |
| cellular response to cold | |
| apoptotic process | |
| innate immune response | |
| response to lipopolysaccharide | |
| response to muramyl dipeptide | |
| response to exogenous dsRNA | |
| negative regulation of lipid storage | |
| positive regulation of type I interferon production | |
| positive regulation of cholesterol efflux | |
| protein import into nucleus, translocation | |
| negative regulation of DNA binding |
| Pathway | EctodysplasinR -> NF-kB signaling |
|---|---|
| TNFR -> NF-kB signaling | |
| NGFR -> NF-kB signaling | |
| Notch -> NF-kB signaling | |
| T-cell receptor -> NF-kB signaling | |
| TLR3 -> NF-kB signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| IL1R -> NF-kB signaling | |
| AGER -> NF-kB signaling | |
| DDR1 -> NF-kB signaling | |
| MacrophageR -> CEBPB/NF-kB signaling | |
| FibronectinR -> NF-kB signaling | |
| B-cell receptor -> NF-kB signaling | |
| CD19 -> NF-kB signaling | |
| IL7R -> FOXO/NF-kB signaling | |
| IL12R -> NF-kB/NFATC signaling | |
| IL15R -> NF-kB/NFATC signaling | |
| ErythropoietinR -> NF-kB signaling | |
| CSF2R -> NF-kB signaling | |
| GHR -> NF-kB signaling | |
| DopamineR2 -> NF-kB signaling | |
| PTAFR -> NF-kB signaling | |
| AdenosineR -> NF-kB signaling | |
| ThrombinR -> NF-kB signaling | |
| CD38 -> NF-kB signaling | |
| Cyclosporine-Induced Nephrotoxicity | |
| Doxorubicin-Induced Cardiotoxicity | |
| Cytosolic Calcium Overload | |
| Clozapine-Induced Granulocytopenia | |
| Glutamate-Mediated Excitotoxicity | |
| ROS in Triggering Vascular Inflammation | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| TLR3 Expression Targets | |
| FASLG Expression Targets | |
| BDNF Expression Targets | |
| NTF3 Expression Targets | |
| NTF4 Expression Targets | |
| DLL1 Expression Targets | |
| DLL4 Expression Targets | |
| ADAM17 Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| JAG1 Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| EDA Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| NGF/SMAD3/NF-kB Expression Targets | |
| ICAM1 Expression Targets | |
| Fibrinogen Expression Targets | |
| Fibronectin Expression Targets | |
| CD21 Expression Targets | |
| Gamma Globulins Expression Targets | |
| PECAM1 Expression Targets | |
| CD19 Expression Targets | |
| CD81 Expression Targets | |
| IL12B Expression Targets | |
| IL15 Expression Targets | |
| IL7 Expression Targets | |
| Erythropoietin/NF-kB Expression Targets | |
| GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| CSH1-GHR Expression Targets | |
| CSF2/NF-kB Expression Targets | |
| Dopamine/Gi Expression Targets | |
| S100B Expression Targets | |
| S100P Expression Target | |
| HMGB1 Expression Targets | |
| TTR Expression Targets | |
| Collagen/NF-kB Expression Targets | |
| F2 -> STAT1/NF-kB Expression Targets | |
| PLG -> STAT1/NF-kB Expression Targets | |
| Adenosine Expression Targets | |
| PAF/Gq -> NF-kB Expression Targets | |
| IL16/NF-kB Expression Targets | |
| CD8/NF-kB Expression Targets | |
| CD80/NF-kB Expression Targets | |
| CD86/NF-kB Expression Targets | |
| CD22/NF-kB Expression Targets | |
| CD72/NF-kB Expression Targets | |
| PDCD1/NF-kB Expression Targets | |
| TCR/NF-kB Expression Targets | |
| IL1A Expression Targets | |
| NOTCH Expression Targets | |
| TNF/NF-kB Expression Targets | |
| IL1B Expression Targets | |
| EGF/CTNN Expression Targets | |
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | NFKBI |
|---|---|
| virus-host interaction | |
| negative regulation of Notch signaling pathway | |
| regulation of NF-kappaB import into nucleus | |
| cytoplasmic sequestering of NF-kappaB | |
| regulation of cell proliferation | |
| nucleotide-binding oligomerization domain containing 2 signaling pathway | |
| nucleotide-binding oligomerization domain containing 1 signaling pathway | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| lipopolysaccharide-mediated signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of cellular protein metabolic process | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of NF-kappaB transcription factor activity | |
| negative regulation of myeloid cell differentiation | |
| negative regulation of macrophage derived foam cell differentiation | |
| cytoplasmic sequestering of transcription factor | |
| negative regulation of apoptotic process | |
| cellular response to cold | |
| apoptotic process | |
| innate immune response | |
| response to lipopolysaccharide | |
| response to muramyl dipeptide | |
| response to exogenous dsRNA | |
| negative regulation of lipid storage | |
| positive regulation of type I interferon production | |
| positive regulation of cholesterol efflux | |
| protein import into nucleus, translocation | |
| negative regulation of DNA binding | |
| heat shock protein binding | |
| protein complex binding | |
| transcription factor binding | |
| enzyme binding | |
| NF-kappaB binding | |
| ubiquitin protein ligase binding | |
| nuclear localization sequence binding | |
| protein complex | |
| I-kappaB-NF-kappaB complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| MedScan ID | 4792 |
|---|
| Hugo ID | 7797 |
|---|
| Human chromosome position | 14q13 |
|---|
| LocusLink ID | 4792 |
|---|---|
| 18035 | |
| 25493 | |
| 104829 | |
| 282291 | |
| 323099 |
| Alias | IKBA |
|---|---|
| MAD-3 | |
| NFKBI | |
| NF-kappa-B inhibitor alpha | |
| ikB-alpha | |
| IkappaBalpha | |
| I-kappa-B-alpha | |
| nuclear factor of kappa light chain gene enhancer in B-cells | |
| major histocompatibility complex enhancer-binding protein MAD3 | |
| AI462015 | |
| I-kappaBalpha | |
| I(Kappa)B(alpha) | |
| nuclear factor of kappa light polyp gene enhancer in B-cell 1 | |
| nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | |
| RL/IF-1 | |
| Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha | |
| Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha | |
| NFKBIA | |
| nuclear factor of kappa light chain gene enhancer in b-cells inhibitor | |
| NF-kappaB inhibitor alpha | |
| nuclear factor of kappa light polyp gene enhancer in B-cell I | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibito | |
| P-I-kappaB-alpha | |
| MAD-III | |
| RL/IF I | |
| Major histocompatibility complex enhancer- binding protein MAD3 | |
| IkappaB/MAD3 | |
| major histocompatibility complex enhance-binding protein MAD3 | |
| IkappaB-alpha/MAD3 | |
| IKBA_HUMAN | |
| Inhibitor of 3000097 | |
| MAD-3/I kappa B alpha | |
| IkBalpha | |
| Ikappa-Balpha | |
| RL/IF-1s | |
| lkappa-Balpha | |
| expressed sequence AI462015 | |
| RL/IF Is | |
| I-kappaB-alpha | |
| MAD III | |
| MGC56666 | |
| NF-kappaB inhibitor alpha-like protein B | |
| alpha b | |
| chromosome | |
| fb81f08 | |
| ikbaB | |
| nfkbiab | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b | |
| scaffold | |
| wu:fb81f08 | |
| zgc:56666 | |
| zgc:77616 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio | |
| Human |
| OMIM ID | 164008 |
|---|---|
| 612132 | |
| OMIM:164008 |
| Unigene ID | Hs.81328 |
|---|---|
| Mm.170515 | |
| Rn.12550 | |
| Bt.9027 | |
| Dr.77409 | |
| Rn.104476 |
| KEGG ID | hsa:4792 |
|---|---|
| mmu:18035 | |
| rno:25493 |
| Swiss-Prot Accession | P25963 |
|---|---|
| Q9Z1E3 | |
| Q63746 | |
| B2R8L6 | |
| B2RYS5 | |
| Q3U9W9 | |
| Q3UB40 | |
| Q80ZX5 | |
| Q9UGJ5 |
| GO ID | 0051059 |
|---|---|
| 0019899 | |
| 0031072 | |
| 0008139 | |
| 0008134 | |
| 0031625 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0006915 | |
| 0070417 | |
| 0007253 | |
| 0042994 | |
| 0045087 | |
| 0031663 | |
| 0043392 | |
| 0032088 | |
| 0045746 | |
| 0010888 | |
| 0010745 | |
| 0045638 | |
| 0048011 | |
| 0070427 | |
| 0070431 | |
| 0051092 | |
| 0032270 | |
| 0010875 | |
| 0045944 | |
| 0032481 | |
| 0000060 | |
| 0042345 | |
| 0042127 | |
| 0043330 | |
| 0032495 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0019048 | |
| 0033256 | |
| 0005737 | |
| 0005829 | |
| 0005634 | |
| 0005886 | |
| 0032403 | |
| 0045893 | |
| 0032496 | |
| 0043234 | |
| 0006916 | |
| 0044419 | |
| 0010552 | |
| 0045941 | |
| 0042802 | |
| 0045833 | |
| 0032376 | |
| 0005515 | |
| 0009618 | |
| 0009617 | |
| 0003719 |
| PIR ID | A39935 |
|---|---|
| A44437 |
| Swiss-Prot ID | IKBA_HUMAN |
|---|---|
| IKBA_RAT | |
| IKBA_MOUSE | |
| B2RYS5_RAT | |
| Q3UB40_MOUSE | |
| B2R8L6_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00018330 |
|---|---|
| IPI00211841 | |
| IPI00331017 |
| Mouse chromosome position | 12 |
|---|---|
| 12 C1-C3 |
| Rat chromosome position | 6q23 |
|---|
| Homologene ID | 7863 |
|---|
| MGI ID | 104741 |
|---|---|
| 2144835 |
| RGD ID | 3171 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 14q13 |
|---|
| Microarray ID | 101554_at |
|---|---|
| 104149_at | |
| X63594cds_at | |
| X63594cds_g_at | |
| A_42_P544487 | |
| 206329_Rn | |
| Msa.1690.0_at | |
| Msa.1690.0_g_at | |
| 1448306_at | |
| 133630_r_at | |
| 1438157_s_at | |
| 167965_f_at | |
| A_65_P03979 | |
| H3026A08-3 | |
| A_51_P295192 | |
| NM_010907 | |
| 201502_s_at | |
| 231699_at | |
| 1461_at | |
| M69043_at | |
| A_23_P106002 | |
| I_959455 | |
| A_14_P120088 | |
| A_14_P114684 | |
| A_14_P133399 | |
| 1420088_at | |
| 1449731_s_at |
| FunctionalClass | NF-kappaB binding |
|---|---|
| nuclear localization sequence binding | |
| ubiquitin protein ligase binding | |
| protein binding | |
| heat shock protein binding | |
| transcription factor binding |
| Mus musculus Chromosome position | 12 C1-C3 |
|---|---|
| 12 |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis | |
| B cell receptor signaling pathway | |
| Chronic myeloid leukemia | |
| Small cell lung cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway |
| Rattus norvegicus Chromosome position | 6q23 |
|---|
| Bos taurus Chromosome position | 21 |
|---|
| Keyword | cytoplasm |
|---|---|
| ubiquitin | |
| nucleus | |
| DNA | |
| binding activity | |
| kinetochore |
| Proteome Biochemical Function | Inhibitor or repressor |
|---|
| Proteome Organismal Role | Cell death/Apoptosis |
|---|---|
| Anti-pathogen response |
| Proteome Subcellular Localization | Cytoplasmic |
|---|
| Compartment | cytoplasm |
|---|---|
| DNA | |
| void |
| RefSeq ACCNUM | NP_065390 |
|---|