Protein Tab1

URN	urn:agi-llid:10454
Total Entities	0
Connectivity	131
Name	Tab1
Description	TGF-beta activated kinase 1/MAP3K7 binding protein 1
Notes	The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Ariadne Ontology	Secreted proteins

GO Molecular Function	catalytic activity
	protein complex binding
	mitogen-activated protein kinase p38 binding
	kinase activator activity
	enzyme activator activity

GO Biological Process	metabolic process
	activation of MAPKKK activity
	positive regulation of MAP kinase activity
	activation of MAPK activity
	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
	nucleotide-binding oligomerization domain containing signaling pathway
	I-kappaB kinase-NF-kappaB cascade
	stress-activated MAPK cascade
	JNK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 3 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	MyD88-independent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	TRIF-dependent toll-like receptor signaling pathway
	Toll signaling pathway
	transforming growth factor beta receptor signaling pathway
	positive regulation of NF-kappaB transcription factor activity
	innate immune response
	lung development
	in utero embryonic development
	heart morphogenesis

Pathway	DDR1 -> NF-kB signaling
	Collagen/NF-kB Expression Targets
	nuclear factor kappa B signaling pathway
	tumor necrosis factor signaling pathway
	tumor necrosis factor mediated signaling pathway

Group	metabolic process
	activation of MAPKKK activity
	positive regulation of MAP kinase activity
	activation of MAPK activity
	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
	nucleotide-binding oligomerization domain containing signaling pathway
	I-kappaB kinase-NF-kappaB cascade
	stress-activated MAPK cascade
	JNK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 3 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	MyD88-independent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	TRIF-dependent toll-like receptor signaling pathway
	Toll signaling pathway
	transforming growth factor beta receptor signaling pathway
	positive regulation of NF-kappaB transcription factor activity
	innate immune response
	lung development
	in utero embryonic development
	heart morphogenesis
	catalytic activity
	protein complex binding
	mitogen-activated protein kinase p38 binding
	kinase activator activity
	enzyme activator activity
	endosome membrane
	protein complex
	cytosol
	Secreted proteins

MedScan ID	10454
	315139

Hugo ID	18157

Human chromosome position	22q13.1

Alias	3'-Tab1
	MAP3K7IP1
	RP3-407F17.2
	TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
	TAK1-binding protein 1
	transforming growth factor beta-activated kinase-binding protein 1
	mitogen-activated protein kinase kinase kinase 7-interacting protein 1
	2310012M03Rik
	beta activated kinase-1 binding protein-1
	TGF-beta-activated kinase 1-binding protein 1
	mitogen activated protein kinase kinase kinase 7 interacting protein 1
	mitogen-activated protein kinase kinase kinase 7 interacting protein 1
	TAB I
	TAB1
	TAK1 binding protein
	TAK1-binding protein
	transforming growth factor beta-activated kinase-binding protein I
	TGF-beta activated kinase 1/MAP3K7 binding protein 1
	mitogen-activated protein kinase kinase kinase 7 interactive protein I
	TAK1-binding protein I
	2310012M03
	beta activated kinase-1 binding protein I
	mitogen-activated protein kinase kinase kinase 7 interacting protein I
	Map3k7ip I
	MGC57664
	LOC315139
	mitogen-activated protein kinase kinase kinase 7 interactive protein 1

OMIM ID	602615

Swiss-Prot ID	TAB1_MOUSE
	TAB1_HUMAN

IPI ID	IPI00380503
	IPI00019459

Mouse chromosome position	15

Rat chromosome position	7q34

Homologene ID	4461

MGI ID	1913763

RGD ID	1306216