| URN | urn:agi-llid:5970 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1528 |
| Name | Rela |
| Description | v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
| Notes | component of the NF-kappa B complex; involved in transcriptional activation [RGD] |
| Ariadne Ontology | NF-kB |
|---|---|
| Oncogenes | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | chromatin binding |
|---|---|
| protein complex binding | |
| transcription factor binding | |
| protein N-terminus binding | |
| enzyme binding | |
| activating transcription factor binding | |
| repressing transcription factor binding | |
| NF-kappaB binding | |
| protein kinase binding | |
| ubiquitin protein ligase binding | |
| ankyrin repeat binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| phosphate ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| transcription factor complex | |
| protein complex | |
| NF-kappaB complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | response to bacterium |
|---|---|
| defense response to virus | |
| virus-host interaction | |
| negative regulation of insulin receptor signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| nucleotide-binding oligomerization domain containing 2 signaling pathway | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| cytokine-mediated signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of chondrocyte differentiation | |
| positive regulation of Schwann cell differentiation | |
| transcription, DNA-dependent | |
| acetaldehyde metabolic process | |
| cellular response to interleukin-1 | |
| cellular response to tumor necrosis factor | |
| cellular response to lipopolysaccharide | |
| innate immune response | |
| response to stress | |
| response to organic substance | |
| response to drug | |
| response to inorganic substance | |
| response to hydrogen peroxide | |
| response to morphine | |
| response to amino acid stimulus | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to muramyl dipeptide | |
| response to progesterone stimulus | |
| response to insulin stimulus | |
| response to cobalamin | |
| response to cAMP | |
| response to interleukin-1 | |
| defense response | |
| cellular defense response | |
| inflammatory response | |
| regulation of inflammatory response | |
| response to mechanical stimulus | |
| response to UV-B | |
| negative regulation of protein catabolic process | |
| positive regulation of type I interferon production | |
| aging | |
| liver development | |
| hair follicle development | |
| organ morphogenesis | |
| membrane protein intracellular domain proteolysis |
| Pathway | IFNA1/Gq Expression Targets |
|---|---|
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | NF-kB |
|---|---|
| Oncogenes | |
| response to bacterium | |
| defense response to virus | |
| virus-host interaction | |
| negative regulation of insulin receptor signaling pathway | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| nucleotide-binding oligomerization domain containing 2 signaling pathway | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| cytokine-mediated signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of interleukin-12 biosynthetic process | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of transcription, DNA-dependent | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of cell proliferation | |
| positive regulation of chondrocyte differentiation | |
| positive regulation of Schwann cell differentiation | |
| transcription, DNA-dependent | |
| acetaldehyde metabolic process | |
| cellular response to interleukin-1 | |
| cellular response to tumor necrosis factor | |
| cellular response to lipopolysaccharide | |
| innate immune response | |
| response to stress | |
| response to organic substance | |
| response to drug | |
| response to inorganic substance | |
| response to hydrogen peroxide | |
| response to morphine | |
| response to amino acid stimulus | |
| response to cytokine stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to muramyl dipeptide | |
| response to progesterone stimulus | |
| response to insulin stimulus | |
| response to cobalamin | |
| response to cAMP | |
| response to interleukin-1 | |
| defense response | |
| cellular defense response | |
| inflammatory response | |
| regulation of inflammatory response | |
| response to mechanical stimulus | |
| response to UV-B | |
| negative regulation of protein catabolic process | |
| positive regulation of type I interferon production | |
| aging | |
| liver development | |
| hair follicle development | |
| organ morphogenesis | |
| membrane protein intracellular domain proteolysis | |
| chromatin binding | |
| protein complex binding | |
| transcription factor binding | |
| protein N-terminus binding | |
| enzyme binding | |
| activating transcription factor binding | |
| repressing transcription factor binding | |
| NF-kappaB binding | |
| protein kinase binding | |
| ubiquitin protein ligase binding | |
| ankyrin repeat binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region DNA binding | |
| phosphate ion binding | |
| sequence-specific DNA binding transcription factor activity | |
| RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity | |
| nucleoplasm | |
| transcription factor complex | |
| protein complex | |
| NF-kappaB complex | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| MedScan ID | 5970 |
|---|
| Hugo ID | 9955 |
|---|
| Human chromosome position | 11q13 |
|---|
| LocusLink ID | 5970 |
|---|---|
| 19697 | |
| 309165 | |
| 508233 | |
| 415099 | |
| 309166 |
| Alias | p65 |
|---|---|
| NFKB3 | |
| transcription factor p65 | |
| NF-kappa-B p65delta3 | |
| nuclear factor NF-kappa-B p65 subunit | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 | |
| p65 NFkB | |
| p65 NF kappaB | |
| p65 NF-kappa B | |
| avian reticuloendotheliosis viral (v-rel) oncogene homolog A | |
| NFkB | |
| nuclear factor kappa B subunit p65 | |
| Rel A | |
| RELA | |
| TF65_MOUSE | |
| v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3) | |
| v-rel homolog A | |
| v-rel oncogene homolog A | |
| v-rel reticuloendotheliosis viral oncogene homolog A | |
| v-rel reticuloendotheliosis viral oncogene homolog A (avian) | |
| NF kappa B p65 | |
| NF kappa B 3 | |
| v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 | |
| MGC131774 | |
| NF kappa B III | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 ( | |
| OTTMUSP00000017977 | |
| LOC309165 | |
| v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)) | |
| v-rel avian reticuloendotheliosis viral oncogene homolog A | |
| NF kappa B p65 | |
| V-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | |
| nuclear factor kappa-B chain p65 | |
| TF65 | |
| TF65_HUMAN | |
| similar to v-rel reticuloendotheliosis viral oncogene homolog A,; avian reticuloendotheliosis viral (v-rel) oncogene homolog A; p65 NF-kappa B; p65 NFkB | |
| P65 transcription factor | |
| chromosome | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio | |
| Human |
| OMIM ID | 164014 |
|---|---|
| OMIM:164014 |
| Unigene ID | Hs.502875 |
|---|---|
| Mm.249966 | |
| Rn.19480 | |
| Mm.472744 | |
| Bt.26220 | |
| Dr.84126 | |
| Mm.458220 | |
| Hs.132594 | |
| Rn.97604 | |
| Mm.28170 | |
| Hs.75569 |
| KEGG ID | hsa:5970 |
|---|---|
| mmu:19697 | |
| rno:309165 |
| Swiss-Prot Accession | Q04206 |
|---|---|
| Q04207 | |
| Q548Y4 | |
| Q7TQN4 | |
| Q6GTV1 | |
| Q6SLK1 | |
| Q62025 | |
| Q2TAM5 | |
| Q96CP1 | |
| Q96F54 | |
| Q3U3Q8 | |
| Q4U113 | |
| Q8BTL4 | |
| O88619 | |
| TF65_HUMAN |
| GO ID | 0003677 |
|---|---|
| 0051059 | |
| 0003705 | |
| 0033613 | |
| 0071532 | |
| 0003682 | |
| 0042301 | |
| 0047485 | |
| 0019901 | |
| 0070491 | |
| 0043565 | |
| 0003700 | |
| 0008134 | |
| 0044212 | |
| 0031625 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0006117 | |
| 0007568 | |
| 0006968 | |
| 0071347 | |
| 0071222 | |
| 0071356 | |
| 0019221 | |
| 0051607 | |
| 0001942 | |
| 0006954 | |
| 0045087 | |
| 0001889 | |
| 0031293 | |
| 0043066 | |
| 0046627 | |
| 0042177 | |
| 0045892 | |
| 0048011 | |
| 0070431 | |
| 0009887 | |
| 0043123 | |
| 0051092 | |
| 0014040 | |
| 0008284 | |
| 0032332 | |
| 0045084 | |
| 0045944 | |
| 0045893 | |
| 0032481 | |
| 0050727 | |
| 0010224 | |
| 0043200 | |
| 0051591 | |
| 0033590 | |
| 0042493 | |
| 0042542 | |
| 0032868 | |
| 0070555 | |
| 0009612 | |
| 0043278 | |
| 0032495 | |
| 0010033 | |
| 0032570 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0019048 | |
| 0005737 | |
| 0005829 | |
| 0005654 | |
| 0005634 | |
| 0005667 | |
| 0019899 | |
| 0032403 | |
| 0006952 | |
| 0006355 | |
| 0009617 | |
| 0006351 | |
| 0071159 | |
| 0043234 | |
| 0034097 | |
| 0010035 | |
| 0032496 | |
| 0014070 | |
| 0006950 | |
| 0006916 | |
| 0010843 | |
| 0016563 | |
| 0016564 | |
| 0044419 | |
| 0032582 | |
| 0045449 | |
| 0006350 | |
| 0042802 | |
| 0004672 | |
| 0005515 | |
| 0004871 | |
| 0007498 | |
| 0043065 | |
| 0008151 | |
| 0000074 | |
| 0045182 |
| PIR ID | A40851 |
|---|---|
| I53719 | |
| S51782 | |
| A37932 | |
| PC4233 | |
| S48113 |
| Swiss-Prot ID | TF65_HUMAN |
|---|---|
| TF65_MOUSE | |
| Q7TQN4_RAT | |
| Q548Y4_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00219084 |
|---|---|
| IPI00386448 | |
| IPI00479470 | |
| IPI00884950 | |
| IPI00134188 | |
| IPI00229014 | |
| IPI00396903 | |
| IPI00883897 | |
| IPI00608051 | |
| IPI00874769 | |
| IPI00779301 | |
| IPI00567368 |
| Mouse chromosome position | 19 0.5 cM |
|---|
| Rat chromosome position | 1q43 |
|---|
| Homologene ID | 32064 |
|---|
| MGI ID | 103290 |
|---|
| RGD ID | 727889 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| Homo sapiens Chromosome position | 11q13 |
|---|
| Microarray ID | 162042_i_at |
|---|---|
| 97813_at | |
| 1419536_a_at | |
| 99300_at | |
| 131739_f_at | |
| 170357_r_at | |
| M61909_s_at | |
| Msa.1018.0_at | |
| A_65_P08327 | |
| H3131E07-5 | |
| A_65_P17567 | |
| C0190G02-3 | |
| A_51_P385996 | |
| NM_009045 | |
| A_65_P11040 | |
| L0863C08-3 | |
| L19067 | |
| 230202_at | |
| 36645_at | |
| 87568_at | |
| 1045_s_at | |
| 209878_s_at | |
| 1271_g_at | |
| 1295_at | |
| 201783_s_at | |
| 236891_at | |
| 74793_at | |
| L19067_at | |
| Z22951_rna1_s_at | |
| u33838_s_at | |
| A_23_P104689 | |
| I_938045 | |
| A_51_P385993 | |
| A_14_P115069 | |
| A_14_P128122 |
| FunctionalClass | NF-kappaB binding |
|---|---|
| RNA polymerase II transcription factor activity, enhancer binding | |
| identical protein binding | |
| phosphate binding | |
| protein N-terminus binding | |
| protein kinase | |
| protein kinase binding | |
| signal transducer | |
| transcription factor | |
| DNA binding | |
| transcriptional activator | |
| protein binding | |
| protein self binding | |
| transcription activator |
| Mus musculus Chromosome position | 19 0.5 cM |
|---|
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis | |
| Chronic myeloid leukemia | |
| Pancreatic cancer | |
| Small cell lung cancer | |
| Toll-like receptor signaling pathway |
| Rattus norvegicus Chromosome position | 1q43 |
|---|
| Bos taurus Chromosome position | 29 |
|---|
| Keyword | nucleus |
|---|---|
| cytoplasm | |
| DNA binding activity |