| URN | urn:agi-llid:5966 |
|---|---|
| Total Entities | 0 |
| Connectivity | 807 |
| Name | Rel |
| Description | v-rel reticuloendotheliosis viral oncogene homolog (avian) |
| Notes | The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 [PubMed 18037997]).[supplied by OMIM] |
| Ariadne Ontology | NF-kB |
|---|---|
| Oncogenes | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | DNA binding |
|---|---|
| sequence-specific DNA binding | |
| sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| transcription factor complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of interleukin-12 biosynthetic process | |
| negative regulation of neuron death | |
| transcription, DNA-dependent | |
| cytokine production |
| Pathway | TLR4/NF-kB/IRF Expression Targets |
|---|---|
| S100B Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | NF-kB |
|---|---|
| Oncogenes | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of interleukin-12 biosynthetic process | |
| negative regulation of neuron death | |
| transcription, DNA-dependent | |
| cytokine production | |
| DNA binding | |
| sequence-specific DNA binding | |
| sequence-specific DNA binding transcription factor activity | |
| nucleoplasm | |
| transcription factor complex | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5966 |
|---|
| Hugo ID | 9954 |
|---|
| Human chromosome position | 2p13-p12 |
|---|
| LocusLink ID | 5966 |
|---|---|
| 19696 | |
| 305584 |
| Alias | C-Rel |
|---|---|
| proto-oncogene c-Rel | |
| C-Rel proto-oncogene protein | |
| oncogene REL, avian reticuloendotheliosis | |
| v-rel avian reticuloendotheliosis viral oncogene homolog | |
| reticuloendotheliosis oncogene | |
| v-rel reticuloendotheliosis viral oncogene homolog | |
| REL | |
| rel oncogene | |
| REL_HUMAN | |
| transforming protein (c-rel) | |
| v-rel reticuloendotheliosis viral oncogene homolog (avian) | |
| v-rel oncogene homolog | |
| v-rel homolog | |
| cREL | |
| avian reticuloendotheliosis gene | |
| oncogene rel | |
| Oncogene REL reticuloendotheliosis | |
| OTTMUSP00000005467 | |
| NF-kappa-B/Rel | |
| C-Rel protein | |
| I-Rel | |
| avian reticuloendotheliosis |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 164910 |
|---|
| Unigene ID | Hs.631886 |
|---|---|
| Mm.4869 |
| KEGG ID | hsa:5966 |
|---|---|
| mmu:19696 | |
| rno:305584 |
| Swiss-Prot Accession | Q04864 |
|---|---|
| A4QPD3 | |
| P15307 | |
| Q2PNZ7 | |
| Q6LDY0 | |
| Q17RU2 |
| GO ID | 0003677 |
|---|---|
| 0003700 | |
| 0001816 | |
| 0043123 | |
| 0045084 | |
| 0045893 | |
| 0006351 | |
| 0005829 | |
| 0005654 | |
| 0043565 | |
| 0007249 | |
| 1901215 | |
| 0005737 | |
| 0005634 | |
| 0005667 | |
| 0043526 | |
| 0045449 | |
| 0006355 | |
| 0006350 | |
| 0005515 | |
| 0004871 | |
| 0006366 |
| PIR ID | A60646 |
|---|
| Swiss-Prot ID | REL_HUMAN |
|---|---|
| A4QPD3_MOUSE |
| Cell Localization | Nucleus |
|---|
| IPI ID | IPI00029773 |
|---|---|
| IPI00129426 | |
| IPI00784297 | |
| IPI00776360 |
| Mouse chromosome position | 11 13.0 cM |
|---|
| Rat chromosome position | 14q22 |
|---|
| Homologene ID | 2182 |
|---|
| MGI ID | 97897 |
|---|
| RGD ID | 1311231 |
|---|
| Primary Cell Localization | Nucleus |
|---|