| URN | urn:agi-llid:4791 |
|---|---|
| Total Entities | 0 |
| Connectivity | 176 |
| Name | Nfkb2 |
| Description | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 |
| Notes | NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. For reviews, see Chen et al. (1999) and Baldwin (1996).[supplied by OMIM] |
| Ariadne Ontology | NF-kB |
|---|
| GO Molecular Function | DNA binding |
|---|---|
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| Bcl3-NF-kappaB2 complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | signal transduction |
|---|---|
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| follicular dendritic cell differentiation | |
| transcription, DNA-dependent | |
| extracellular matrix organization | |
| innate immune response | |
| germinal center formation | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| positive regulation of type I interferon production | |
| aging | |
| lymph node development | |
| spleen development |
| Pathway | nuclear factor kappa B signaling pathway |
|---|---|
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | NF-kB |
|---|---|
| signal transduction | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| follicular dendritic cell differentiation | |
| transcription, DNA-dependent | |
| extracellular matrix organization | |
| innate immune response | |
| germinal center formation | |
| response to cytokine stimulus | |
| response to lipopolysaccharide | |
| positive regulation of type I interferon production | |
| aging | |
| lymph node development | |
| spleen development | |
| DNA binding | |
| transcription coactivator activity | |
| sequence-specific DNA binding transcription factor activity | |
| nucleoplasm | |
| nucleolus | |
| Bcl3-NF-kappaB2 complex | |
| cytoplasm | |
| cytosol | |
| nucleus |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 4791 |
|---|
| Hugo ID | 7795 |
|---|
| Human chromosome position | 10q24 |
|---|
| LocusLink ID | 4791 |
|---|---|
| 18034 | |
| 309452 | |
| 368030 | |
| 526392 | |
| 415100 | |
| 334761 |
| Alias | p52 |
|---|---|
| p105 | |
| H2TF1 | |
| LYT10 | |
| LYT-10 | |
| NF-kB2 | |
| nuclear factor NF-kappa-B p100 subunit | |
| oncogene Lyt-10 | |
| DNA-binding factor KBF2 | |
| lymphocyte translocation chromosome 10 protein | |
| nuclear factor of kappa light chain gene enhancer in B-cells 2 | |
| lyt | |
| p49 | |
| p50B | |
| p49/p100 | |
| NF-kappaB2 | |
| NF kappaB2 | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | |
| RGD1307189 | |
| Nuclear factor NF-kappa-B p49 subunit | |
| OTTHUMP00000059136 | |
| OTTHUMP00000020371 | |
| Nuclear factor of kappa light chain gene enhancer in B-cells II | |
| LOC368030 | |
| LYT X | |
| MGC93816 | |
| Nfkb2 | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | |
| P(49) | |
| fa03b02 | |
| wu:fa03b02 | |
| MGC136693 | |
| NF-kB2-I precursor protein | |
| NF-kB2-II precursor protein | |
| P100/P52 transcription factor | |
| chromosome | |
| p100 | |
| scaffold | |
| zgc:136693 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 164012 |
|---|
| Unigene ID | Hs.73090 |
|---|---|
| Mm.102365 | |
| Rn.204814 | |
| Rn.25549 | |
| Bt.20288 | |
| Dr.117553 |
| KEGG ID | hsa:4791 |
|---|---|
| mmu:18034 | |
| rno:309452 |
| Swiss-Prot Accession | Q00653 |
|---|---|
| Q3UG25 | |
| Q3UV15 | |
| Q9WTK5 | |
| Q5U2Z4 | |
| A8K9D9 | |
| D3DR83 | |
| Q04860 | |
| Q9BU75 | |
| Q9H471 | |
| Q9H472 | |
| Q3U5V4 | |
| Q3ULT8 | |
| Q4U105 | |
| Q4U106 | |
| Q4U108 | |
| AAB23437 |
| GO ID | 0003677 |
|---|---|
| 0003700 | |
| 0003713 | |
| 0002755 | |
| 0002756 | |
| 0035666 | |
| 0008063 | |
| 0030198 | |
| 0002268 | |
| 0002467 | |
| 0045087 | |
| 0051092 | |
| 0032481 | |
| 0006355 | |
| 0048536 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0006351 | |
| 0033257 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0048535 | |
| 0007165 | |
| 0007568 | |
| 0034097 | |
| 0032496 | |
| 0045449 | |
| 0006350 | |
| 0005515 | |
| 0050875 |
| PIR ID | A42024 |
|---|---|
| A57034 | |
| I38609 | |
| S17233 |
| Swiss-Prot ID | NFKB2_MOUSE |
|---|---|
| NFKB2_HUMAN | |
| Q3UG25_MOUSE | |
| A8K9D9_HUMAN | |
| D3DR83_HUMAN | |
| Q5U2Z4_RAT |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00123474 |
|---|---|
| IPI00807463 | |
| IPI00845373 | |
| IPI00973137 | |
| IPI00411715 | |
| IPI00196187 |
| Mouse chromosome position | 19 45.75 cM |
|---|
| Rat chromosome position | 1q54 |
|---|
| Homologene ID | 1873 |
|---|
| MGI ID | 1099800 |
|---|
| RGD ID | 1307189 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| Homo sapiens Chromosome position | 10q24 |
|---|
| Microarray ID | 103614_at |
|---|
| FunctionalClass | protein binding |
|---|---|
| transcription coactivator | |
| transcription factor | |
| DNA binding |
| Mus musculus Chromosome position | 19 45.75 cM |
|---|
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis | |
| B cell receptor signaling pathway | |
| Chronic myeloid leukemia | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Calcium signaling pathway | |
| Small cell lung cancer | |
| Prostate cancer |
| Rattus norvegicus Chromosome position | 1q54 |
|---|---|
| 1 |
| Bos taurus Chromosome position | 26 |
|---|