Protein Map3k14

URN	urn:agi-llid:9020
Total Entities	0
Connectivity	469
Name	Map3k14
Description	mitogen-activated protein kinase kinase kinase 14 (predicted)
Notes	This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Ariadne Ontology	NIK
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	nucleotide binding
	ATP binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity
	NF-kappaB-inducing kinase activity

GO Cellular Component	cytoplasm
	cytosol
	intracellular membrane-bounded organelle
	nucleus

GO Biological Process	positive regulation of I-kappaB kinase-NF-kappaB cascade
	activation of MAPKK activity
	signal transduction by phosphorylation
	NIK-NF-kappaB cascade
	I-kappaB kinase-NF-kappaB cascade
	MAPK cascade
	T cell costimulation
	protein phosphorylation
	phosphorylation
	cellular response to mechanical stimulus
	immune response

Pathway	EctodysplasinR -> NF-kB signaling
	NGFR -> AP-1/CEBPB/CREB/ELK-SRF/TP53 signaling
	TNFR -> NF-kB signaling
	NGFR -> NF-kB signaling
	TNFR -> AP-1/ATF/TP53 signaling
	TNFRSF1A -> AP-1/ATF/TP53 signaling
	EndothelinRa -> AP-1/CREB signaling
	FASLG Expression Targets
	BDNF Expression Targets
	NTF3 Expression Targets
	NTF4 Expression Targets
	CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets
	TNFSF13 Expression Targets
	TNFSF13B Expression Targets
	EDA Expression Targets
	TNFSF10 Expression Targets
	LTA Expression Targets
	TNFSF14 Expression Targets
	NGF/SMAD3/NF-kB Expression Targets
	CD40LG/ATF2/AP-1/TP53/E2F Expression Targets
	EDN1 Expression Targets
	EDN3 Expression Targets
	TNF/NF-kB Expression Targets
	nuclear factor kappa B signaling pathway
	nuclear factor kappa B signaling pathway
	nuclear factor kappa B signaling pathway

Group	NIK
	positive regulation of I-kappaB kinase-NF-kappaB cascade
	activation of MAPKK activity
	signal transduction by phosphorylation
	NIK-NF-kappaB cascade
	I-kappaB kinase-NF-kappaB cascade
	MAPK cascade
	T cell costimulation
	protein phosphorylation
	phosphorylation
	cellular response to mechanical stimulus
	immune response
	nucleotide binding
	ATP binding
	transferase activity
	transferase activity, transferring phosphorus-containing groups
	kinase activity
	protein kinase activity
	protein serine-threonine kinase activity
	MAP kinase kinase kinase activity
	NF-kappaB-inducing kinase activity
	cytoplasm
	cytosol
	intracellular membrane-bounded organelle
	nucleus
	Secreted proteins
	Biofluids assayable substances

Source	Curated
	ResNet

MedScan ID	9020

Hugo ID	6853

Human chromosome position	17q21

Alias	HS
	NIK
	HSNIK
	FTDCR1B
	mitogen-activated protein kinase kinase kinase 14
	NF-kappa-beta-inducing kinase
	serine/threonine protein-kinase
	serine/threonine-protein kinase NIK
	aly
	RP23-341C5.5
	alymphoplasia
	protein kinase
	Nfkb inducing kinase
	NF kappa B-inducing kinase
	NF-kappaB-inducible kinase
	NF-kB-inducible kinase
	NFkB-inducible kinase
	NIK kinase
	OTTMUSP00000002951
	Serine/threonine protein kinase NIK
	NFkappaB inducing kinase
	NF-kB-inducing kinase
	NFkappaB-inducible kinase
	NF-kappa beta-inducible kinase
	alymphoplasia gene
	kinase NIK
	LOC284209
	Map3k14
	MAPKKK14
	NF-kappa beta-inducing kinase
	NF-kappaB-inducing kinase
	alymphoplasia protein
	NF- kappa beta-inducing kinase
	mitogen-activated protein kinase kinase kinase 14 (predicted)
	LOC569330
	chromosome
	hypothetical LOC569330
	scaffold

OMIM ID	604655

EC Number	2.7.11.25

Cell Localization	Cytoplasm

Mouse chromosome position	11 63.0 cM

Rat chromosome position	10q32.1

Homologene ID	2940

MGI ID	1858204

RGD ID	1310487

Primary Cell Localization	Cytoplasm

Homo sapiens Chromosome position	17q21

FunctionalClass	ATP binding
	nucleotide binding
	protein binding
	protein kinase
	protein serine/threonine kinase
	transferase
	kinase
	protein-tyrosine kinase

Mus musculus Chromosome position	11 63.0 cM

KEGG pathway	Apoptosis
	MAPK signaling pathway
	T cell receptor signaling pathway

Rattus norvegicus Chromosome position	10q32.1

Bos taurus Chromosome position	19