| URN | urn:agi-llid:3649 |
|---|---|
| Total Entities | 0 |
| Connectivity | 561 |
| Name | Ikbkg |
| Description | inhibitor of kappaB kinase gamma |
| Notes | regulatory subunit of the I kappa B kinase complex, which phosphorylates and activates NF kappa B [RGD] |
| Ariadne Ontology | IKBK |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein domain specific binding |
|---|---|
| protein heterodimerization activity | |
| metal ion binding | |
| kinase activity | |
| signal transducer activity |
| GO Cellular Component | IkappaB kinase complex |
|---|---|
| intracellular | |
| cytoplasmic part | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | response to virus |
|---|---|
| virus-host interaction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| activation of NF-kappaB-inducing kinase activity | |
| activation of MAPK activity | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| induction of apoptosis | |
| transcription, DNA-dependent | |
| phosphorylation | |
| NF-kappaB import into nucleus | |
| response to DNA damage stimulus | |
| immune response | |
| B cell homeostasis | |
| innate immune response | |
| inflammatory response | |
| positive regulation of type I interferon production |
| Pathway | nuclear factor kappa B signaling pathway |
|---|---|
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | IKBK |
|---|---|
| response to virus | |
| virus-host interaction | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| activation of NF-kappaB-inducing kinase activity | |
| activation of MAPK activity | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| induction of apoptosis | |
| transcription, DNA-dependent | |
| phosphorylation | |
| NF-kappaB import into nucleus | |
| response to DNA damage stimulus | |
| immune response | |
| B cell homeostasis | |
| innate immune response | |
| inflammatory response | |
| positive regulation of type I interferon production | |
| protein domain specific binding | |
| protein heterodimerization activity | |
| metal ion binding | |
| kinase activity | |
| signal transducer activity | |
| IkappaB kinase complex | |
| intracellular | |
| cytoplasmic part | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| ResNet | |
| GO component |
| MedScan ID | 3649 |
|---|---|
| 8517 |
| Hugo ID | 5961 |
|---|
| Human chromosome position | Xq28 |
|---|
| LocusLink ID | 3649 |
|---|---|
| 8517 | |
| 16151 | |
| 309295 | |
| 3650 | |
| 76324 | |
| 102943 | |
| 102948 | |
| 103024 | |
| 109073 | |
| 264636 | |
| 281855 | |
| 541530 | |
| 335806 |
| Alias | IP |
|---|---|
| IP1 | |
| IP2 | |
| FIP3 | |
| IPD2 | |
| NEMO | |
| FIP-3 | |
| Fip3p | |
| AMCBX1 | |
| IKK-gamma | |
| NF-kappa-B essential modulator | |
| IKKG | |
| IKKAP1 | |
| incontinentia pigmenti | |
| IkB kinase gamma subunit | |
| ikB kinase subunit gamma | |
| NFkappaB essential modulator | |
| NF-kappa-B essential modifier | |
| I-kappa-B kinase subunit gamma | |
| ikB kinase-associated protein 1 | |
| inhibitor of nuclear factor kappa-B kinase subunit gamma | |
| IKK[g] | |
| AI848108 | |
| AI851264 | |
| AW124339 | |
| 1110037D23Rik | |
| RP23-15J3.1 | |
| mFIP-3 | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | |
| I-kappa-B kinase gamma | |
| NF-kappa B essential modulator | |
| inhibitor of kappaB kinase gamma | |
| Inhibitor of nuclear factor kappa-B kinase gamma subunit | |
| inhibitor of NF-kB kinase subunit gamma | |
| Inhibitor of NF-kB kinase gamma subunit | |
| inhibitor of NF kappa-B kinase subunit gamma | |
| incontinentia pigmenti-1 | |
| Incontinentia pigmenti-1, sporadic type | |
| LOC264636 | |
| OTTHUMP00000026029 | |
| Inhibitor of NF kappa-B kinase gamma subunit | |
| NF-kappaB essential modifier | |
| OTTHUMP00000026028 | |
| incontinentia pigmenti 1 (sporadic, associated with X chromosome rearrangements) | |
| OTTHUMP00000207079 | |
| OTTHUMP00000212188 | |
| OTTMUSP00000019310 | |
| OTTMUSP00000021358 | |
| OTTMUSP00000021360 | |
| OTTMUSP00000021361 | |
| OTTHUMP00000026027 | |
| FIP IIIs | |
| 1110037D23 | |
| incontinentia pigmenti gene | |
| FIP III | |
| incontinentia pigmenti 2 (familial, male-lethal type) | |
| I kappaB kinase gamma | |
| IKKAP I | |
| incontinentia pigmenti 1 (sporadic, associated with X chromosome rearrangem | |
| IKKAP | |
| IKK(g) | |
| Ikbkg | |
| IkB-gamma | |
| IkB kinase-associated protein I | |
| IP I | |
| IkB kinase gamma subunit | |
| NF-kappaB essential modulator | |
| RIKEN cDNA 1110037D23 gene | |
| IKKAP1s | |
| expressed sequence AI851264 | |
| IKKAP Is | |
| fj33c07 | |
| wu:fj33c07 | |
| chromosome | |
| ikky | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells | |
| kinase gamma | |
| scaffold | |
| zgc:113492 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 300248 |
|---|---|
| 300301 | |
| 300291 | |
| 300584 | |
| 308300 | |
| 300640 | |
| 300636 | |
| 308310 |
| Unigene ID | Hs.43505 |
|---|---|
| Mm.12967 | |
| Rn.214715 | |
| Rn.107053 | |
| Bt.8959 | |
| Dr.132695 | |
| Dr.69759 |
| KEGG ID | hsa:8517 |
|---|---|
| mmu:16151 | |
| rno:309295 |
| Swiss-Prot Accession | Q9Y6K9 |
|---|---|
| Q7TSS3 | |
| A3KG33 | |
| Q8VC91 | |
| E9Q2Y3 | |
| O88522 | |
| Q6TMG5 | |
| Q924H4 | |
| Q7LBY6 | |
| Q7Z7F1 | |
| A6NG82 | |
| Q3UG24 |
| GO ID | 0046872 |
|---|---|
| 0019904 | |
| 0004871 | |
| 0001782 | |
| 0007249 | |
| 0007254 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0007250 | |
| 0006955 | |
| 0006917 | |
| 0006954 | |
| 0045087 | |
| 0035872 | |
| 0070423 | |
| 0043123 | |
| 0051092 | |
| 0032481 | |
| 0006974 | |
| 0009615 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0006351 | |
| 0019048 | |
| 0008385 | |
| 0005737 | |
| 0044444 | |
| 0005829 | |
| 0005622 | |
| 0005634 | |
| 0016301 | |
| 0046982 | |
| 0016310 | |
| 0006355 | |
| 0042348 | |
| 0044419 | |
| 0045449 | |
| 0006350 | |
| 0008270 | |
| 0034984 | |
| 0005515 | |
| 0003674 | |
| 0005575 | |
| 0007252 |
| Swiss-Prot ID | NEMO_RAT |
|---|---|
| NEMO_MOUSE | |
| NEMO_HUMAN | |
| Q7LBY6_HUMAN | |
| A6NG82_HUMAN | |
| Q8VC91_MOUSE | |
| A3KG33_MOUSE | |
| Q7Z7F1_HUMAN | |
| Q7TSS3_MOUSE | |
| Q924H4_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| IPI ID | IPI00400576 |
|---|---|
| IPI00914699 | |
| IPI00002411 | |
| IPI00641117 | |
| IPI00641409 | |
| IPI00831176 | |
| IPI00930829 | |
| IPI00831040 | |
| IPI00645990 | |
| IPI00644803 | |
| IPI00645282 | |
| IPI00852757 | |
| IPI00852832 | |
| IPI00852631 | |
| IPI00852720 | |
| IPI00881584 | |
| IPI00831266 | |
| IPI00831492 | |
| IPI00856315 | |
| IPI00225348 | |
| IPI00831699 | |
| IPI00830230 | |
| IPI00856910 |
| Mouse chromosome position | X |
|---|---|
| X A7.3 |
| Rat chromosome position | Xq37 |
|---|
| Homologene ID | 2698 |
|---|
| MGI ID | 1338074 |
|---|---|
| 1923574 | |
| 2147920 | |
| 2147925 | |
| 2148001 |
| RGD ID | 735223 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | Xp11.21-cen |
|---|---|
| Xq27-q28 | |
| Xq28 |
| Microarray ID | 103216_f_at |
|---|---|
| 94196_at |
| FunctionalClass | kinase |
|---|---|
| protein binding | |
| signal transducer | |
| molecular_function |
| Mus musculus Chromosome position | X A7.3 |
|---|---|
| X A7.1 | |
| X |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis | |
| B cell receptor signaling pathway | |
| Chronic myeloid leukemia | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| Small cell lung cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway |
| Rattus norvegicus Chromosome position | Xq37 |
|---|
| Bos taurus Chromosome position | X |
|---|