| URN | urn:agi-llid:6885 |
|---|---|
| Total Entities | 0 |
| Connectivity | 614 |
| Name | Map3k7 |
| Description | mitogen activated protein kinase kinase kinase 7 (predicted) |
| Notes | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Ariadne Ontology | MAP3K |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | nucleotide binding |
|---|---|
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase kinase kinase activity | |
| MAP kinase kinase activity |
| GO Cellular Component | membrane |
|---|---|
| endosome membrane | |
| Ada2-Gcn5-Ada3 transcription activator complex | |
| IkappaB kinase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol |
| GO Biological Process | positive regulation of I-kappaB kinase-NF-kappaB cascade |
|---|---|
| positive regulation of JNK cascade | |
| activation of NF-kappaB-inducing kinase activity | |
| activation of MAPKK activity | |
| positive regulation of JUN kinase activity | |
| activation of MAPK activity | |
| signal transduction | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| MAPK cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| negative regulation of reactive oxygen species metabolic process | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| negative regulation of necroptosis | |
| positive regulation of T cell activation | |
| transcription, DNA-dependent | |
| protein phosphorylation | |
| I-kappaB phosphorylation | |
| histone H3 acetylation | |
| phosphorylation | |
| apoptotic process | |
| positive regulation of T cell cytokine production | |
| innate immune response | |
| response to stress | |
| positive regulation of interleukin-2 production | |
| angiogenesis | |
| neural tube formation |
| Pathway | Apoptosis |
|---|---|
| TNFR -> NF-kB signaling | |
| EctodysplasinR -> LEF1 signaling | |
| T-cell receptor -> NF-kB signaling | |
| TLR4/5/7/9 -> NF-kB signaling | |
| TLR1/2/6 -> NF-kB signaling | |
| IL1R -> NF-kB signaling | |
| TLR -> AP-1 signaling | |
| DDR1 -> NF-kB signaling | |
| B-cell receptor -> NF-kB signaling | |
| EphrinB -> JUN signaling | |
| CD38 -> NF-kB signaling | |
| TLR4/NF-kB/IRF Expression Targets | |
| TLR5 Expression Targets | |
| TLR7 Expression Targets | |
| TLR9 Expression Targets | |
| TLR1/2/6 Expression Targets | |
| FASLG Expression Targets | |
| CD40LG/NF-kB/ELK-SRF/CREB/NFATC Expression Targets | |
| TNFSF13 Expression Targets | |
| TNFSF13B Expression Targets | |
| TNFSF10 Expression Targets | |
| LTA Expression Targets | |
| TNFSF14 Expression Targets | |
| CD40LG/ATF2/AP-1/TP53/E2F Expression Targets | |
| Gamma Globulins Expression Targets | |
| PECAM1 Expression Targets | |
| Collagen/NF-kB Expression Targets | |
| IL16/NF-kB Expression Targets | |
| CD8/NF-kB Expression Targets | |
| CD80/NF-kB Expression Targets | |
| CD86/NF-kB Expression Targets | |
| CD22/NF-kB Expression Targets | |
| CD72/NF-kB Expression Targets | |
| PDCD1/NF-kB Expression Targets | |
| TCR/NF-kB Expression Targets | |
| IL1A Expression Targets | |
| TNF/NF-kB Expression Targets | |
| TLR4/AP-1 Expression Targets | |
| TLR4/AP-1/EGR1/HIF1A Expression Targets | |
| IL1B Expression Targets | |
| Toll-like receptor signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| p38 MAPK signaling pathway | |
| NOD-like receptor signaling pathway | |
| nuclear factor kappa B signaling pathway | |
| tumor necrosis factor signaling pathway | |
| tumor necrosis factor mediated signaling pathway |
| Group | MAP3K |
|---|---|
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| positive regulation of JNK cascade | |
| activation of NF-kappaB-inducing kinase activity | |
| activation of MAPKK activity | |
| positive regulation of JUN kinase activity | |
| activation of MAPK activity | |
| signal transduction | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| MAPK cascade | |
| stress-activated MAPK cascade | |
| JNK cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| negative regulation of reactive oxygen species metabolic process | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| negative regulation of necroptosis | |
| positive regulation of T cell activation | |
| transcription, DNA-dependent | |
| protein phosphorylation | |
| I-kappaB phosphorylation | |
| histone H3 acetylation | |
| phosphorylation | |
| apoptotic process | |
| positive regulation of T cell cytokine production | |
| innate immune response | |
| response to stress | |
| positive regulation of interleukin-2 production | |
| angiogenesis | |
| neural tube formation | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| MAP kinase kinase kinase activity | |
| MAP kinase kinase activity | |
| membrane | |
| endosome membrane | |
| Ada2-Gcn5-Ada3 transcription activator complex | |
| IkappaB kinase complex | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|
| MedScan ID | 6885 |
|---|
| Hugo ID | 6859 |
|---|
| Human chromosome position | 6q15 |
|---|---|
| 6q16.1-q16.3 |
| LocusLink ID | 6885 |
|---|---|
| 26409 | |
| 313121 | |
| 93774 | |
| 21347 | |
| 230048 |
| Alias | TAK1 |
|---|---|
| MEKK7 | |
| TGF1a | |
| RP1-154G14.1 | |
| mitogen-activated protein kinase kinase kinase 7 | |
| TGF-beta activated kinase 1 | |
| TGF-beta-activated kinase 1 | |
| transforming growth factor-beta-activated kinase 1 | |
| C87327 | |
| B430101B05 | |
| RP23-447J12.1 | |
| mitogen activated protein kinase kinase kinase 7 | |
| transforming growth factor beta-activated kinase 1 | |
| OTTMUSP00000005100 | |
| OTTMUSP00000005101 | |
| TGF beta-activated kinase | |
| TGF-beta- activated kinase I | |
| OTTHUMP00000016873 | |
| Transforming growth factor-beta-activated kinase I | |
| EST C87327 | |
| Map3k7 | |
| MAPKKK7 | |
| mitogen-activated protein kinase kinase kinase VII | |
| OTTHUMP00000016870 | |
| OTTHUMP00000016871 | |
| OTTHUMP00000016872 | |
| TGF-beta- activated kinase 1 | |
| mitogen activated protein kinase kinase kinase 7 (predicted) |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 602614 |
|---|---|
| OMIM:602614 |
| Unigene ID | Hs.594838 |
|---|---|
| Mm.258589 | |
| Rn.24019 | |
| Hs.644143 | |
| Mm.392292 | |
| Hs.290346 | |
| Rn.100643 | |
| Hs.485968 |
| KEGG ID | hsa:6885 |
|---|---|
| mmu:26409 | |
| rno:313121 |
| Swiss-Prot Accession | O43318 |
|---|---|
| Q543B5 | |
| Q923A8 | |
| Q62073 | |
| P0C8E4 | |
| B2RE27 | |
| E1P523 | |
| O43317 | |
| O43319 | |
| Q5TDN2 | |
| Q5TDN3 | |
| Q5TDT7 | |
| Q9NTR3 | |
| Q9NZ70 | |
| Q5U0C9 | |
| Q5U0D0 | |
| Q9UG54 | |
| Q3TXG1 | |
| Q5TDM9 |
| EC Number | 2.7.11.25 |
|---|---|
| 2.7.1.- |
| GO ID | 0005524 |
|---|---|
| 0004708 | |
| 0004709 | |
| 0000287 | |
| 0004672 | |
| 0004674 | |
| 0007249 | |
| 0007252 | |
| 0007254 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0000187 | |
| 0000186 | |
| 0007250 | |
| 0001525 | |
| 0006915 | |
| 0043966 | |
| 0045087 | |
| 0043066 | |
| 0001841 | |
| 0035872 | |
| 0070423 | |
| 0043123 | |
| 0046330 | |
| 0043507 | |
| 0051092 | |
| 0050870 | |
| 0002726 | |
| 0032743 | |
| 0051403 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0006351 | |
| 0007179 | |
| 0005671 | |
| 0008385 | |
| 0005829 | |
| 0010008 | |
| 0005886 | |
| 0016301 | |
| 0046872 | |
| 0000166 | |
| 0016740 | |
| 0016772 | |
| 0000165 | |
| 0060546 | |
| 2000378 | |
| 0016310 | |
| 0006468 | |
| 0006355 | |
| 0006950 | |
| 0007165 | |
| 0005737 | |
| 0016020 | |
| 0005515 | |
| 0004713 |
| PIR ID | JC5955 |
|---|---|
| JC5956 |
| Swiss-Prot ID | M3K7_MOUSE |
|---|---|
| M3K7_HUMAN | |
| M3K7_RAT | |
| Q9NZ70_HUMAN | |
| Q923A8_MOUSE | |
| Q543B5_MOUSE | |
| B2RE27_HUMAN | |
| Q5TDT7_HUMAN |
| Cell Localization | Cytoplasm |
|---|---|
| Cell membrane |
| IPI ID | IPI00121080 |
|---|---|
| IPI00218566 | |
| IPI00218567 | |
| IPI00295738 | |
| IPI00367017 | |
| IPI00241935 | |
| IPI00123967 | |
| IPI00641808 | |
| IPI00648040 | |
| IPI00649898 | |
| IPI00214313 |
| Mouse chromosome position | 4 |
|---|---|
| 4 A5 |
| Rat chromosome position | 5q21 |
|---|
| Homologene ID | 37743 |
|---|
| MGI ID | 1346877 |
|---|---|
| 2135559 | |
| 1203726 |
| RGD ID | 1309438 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|