| URN | urn:agi-llid:3551 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1003 |
| Name | Ikbkb |
| Description | inhibitor of kappaB kinase beta |
| Notes | kinase that may be involved in megakaryocyte polyploidization [RGD] |
| Ariadne Ontology | IKBK |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein kinase binding |
|---|---|
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| IkappaB kinase activity | |
| receptor signaling protein serine-threonine kinase activity |
| GO Cellular Component | membrane |
|---|---|
| membrane raft | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| IkappaB kinase complex | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| response to virus | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| regulation of I-kappaB kinase-NF-kappaB cascade | |
| signal transduction by phosphorylation | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of cation channel activity | |
| protein phosphorylation | |
| I-kappaB phosphorylation | |
| phosphorylation | |
| B cell homeostasis | |
| innate immune response | |
| response to drug | |
| response to toxin | |
| inflammatory response | |
| positive regulation of type I interferon production | |
| positive regulation of sodium ion transport | |
| skeletal muscle contraction |
| Pathway | nuclear factor kappa B signaling pathway |
|---|---|
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | IKBK |
|---|---|
| metabolic process | |
| response to virus | |
| positive regulation of I-kappaB kinase-NF-kappaB cascade | |
| regulation of I-kappaB kinase-NF-kappaB cascade | |
| signal transduction by phosphorylation | |
| nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | |
| nucleotide-binding oligomerization domain containing signaling pathway | |
| I-kappaB kinase-NF-kappaB cascade | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of cation channel activity | |
| protein phosphorylation | |
| I-kappaB phosphorylation | |
| phosphorylation | |
| B cell homeostasis | |
| innate immune response | |
| response to drug | |
| response to toxin | |
| inflammatory response | |
| positive regulation of type I interferon production | |
| positive regulation of sodium ion transport | |
| skeletal muscle contraction | |
| protein kinase binding | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| protein serine-threonine kinase activity | |
| IkappaB kinase activity | |
| receptor signaling protein serine-threonine kinase activity | |
| membrane | |
| membrane raft | |
| CD40 receptor complex | |
| internal side of plasma membrane | |
| IkappaB kinase complex | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 3551 |
|---|
| Hugo ID | 5960 |
|---|
| Human chromosome position | 8p11.2 |
|---|
| LocusLink ID | 3551 |
|---|---|
| 16150 | |
| 84351 | |
| 101997 | |
| 281854 | |
| 563560 |
| Alias | IKK2 |
|---|---|
| IKKB | |
| NFKBIKB | |
| IKK-beta | |
| inhibitor of nuclear factor kappa-B kinase subunit beta | |
| IKK-B | |
| I-kappa-B kinase 2 | |
| I-kappa-B-kinase beta | |
| nuclear factor NF-kappa-B inhibitor kinase beta | |
| IKK-2 | |
| IKK[b] | |
| IKKbeta | |
| AI132552 | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | |
| AIM-1 | |
| inhibitor of kappaB kinase beta | |
| inhibitor of nuclear factor kappa B kinase beta subunit | |
| OTTMUSP00000022456 | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, k | |
| inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase | |
| MGC131801 | |
| NFKBIKBs | |
| FLJ36218 | |
| FLJ33771 | |
| FLJ38368 | |
| FLJ40509 | |
| I kappaB kinase beta | |
| I-kappa-B kinase II | |
| IkB kinase 2 | |
| IkB kinase beta | |
| IkB kinase II | |
| Ikbkb | |
| I-kappa-B kinase 2 | |
| I-kappa-B kinase II | |
| ikk | |
| LOC563560 | |
| chromosome | |
| scaffold | |
| similar to IkB kinase-beta |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 603258 |
|---|
| Unigene ID | Hs.597664 |
|---|---|
| Mm.277886 | |
| Rn.19222 | |
| Hs.656458 | |
| Hs.413513 | |
| Hs.355753 | |
| Bt.9023 | |
| Dr.101105 |
| KEGG ID | hsa:3551 |
|---|---|
| mmu:16150 | |
| rno:84351 |
| Swiss-Prot Accession | O14920 |
|---|---|
| Q5D0E0 | |
| O88351 | |
| G3V8H5 | |
| Q9QY78 | |
| Q9R1J6 | |
| B4DZ30 | |
| B4E0U4 | |
| O75327 | |
| Q32ND9 | |
| Q59GL9 | |
| Q05DR8 | |
| Q3U141 | |
| Q3USX8 | |
| Q3V454 | |
| Q8BQA9 |
| EC Number | 2.7.11.10 |
|---|
| GO ID | 0005524 |
|---|---|
| 0008384 | |
| 0046982 | |
| 0004672 | |
| 0019901 | |
| 0004674 | |
| 0001782 | |
| 0007249 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0006954 | |
| 0045087 | |
| 0048011 | |
| 0035872 | |
| 0070423 | |
| 0043123 | |
| 0051092 | |
| 0045893 | |
| 0032481 | |
| 0006468 | |
| 0042493 | |
| 0009636 | |
| 0009615 | |
| 0003009 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0035631 | |
| 0008385 | |
| 0005829 | |
| 0009898 | |
| 0045121 | |
| 0005634 | |
| 0016301 | |
| 0000166 | |
| 0004702 | |
| 0016740 | |
| 0016772 | |
| 0007252 | |
| 0008152 | |
| 0016310 | |
| 2001259 | |
| 0010765 | |
| 0043122 | |
| 0023014 | |
| 0005737 | |
| 0043231 | |
| 0016020 | |
| 0006916 | |
| 0016563 | |
| 0005792 | |
| 0042802 | |
| 0006464 | |
| 0005515 | |
| 0004713 |
| Swiss-Prot ID | IKKB_MOUSE |
|---|---|
| IKKB_RAT | |
| IKKB_HUMAN | |
| Q5D0E0_MOUSE |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus | |
| Membrane raft |
| IPI ID | IPI00130038 |
|---|---|
| IPI00213608 | |
| IPI00024709 | |
| IPI00798101 | |
| IPI00982033 | |
| IPI01010552 | |
| IPI00556772 | |
| IPI00656051 | |
| IPI00556516 | |
| IPI00796308 | |
| IPI00789633 | |
| IPI00654351 | |
| IPI00653754 | |
| IPI00458320 | |
| IPI00830374 | |
| IPI00831429 | |
| IPI00782738 |
| Mouse chromosome position | 8 |
|---|---|
| 8 A3-A4 |
| Rat chromosome position | 16q12.5 |
|---|
| Homologene ID | 7782 |
|---|
| MGI ID | 1338071 |
|---|---|
| 2142466 |
| RGD ID | 621375 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| Homo sapiens Chromosome position | 8p11.2 |
|---|
| Microarray ID | 93706_at |
|---|
| FunctionalClass | ATP binding |
|---|---|
| identical protein binding | |
| nucleotide binding | |
| protein serine/threonine kinase | |
| protein-tyrosine kinase | |
| transcriptional activator | |
| transferase | |
| kinase | |
| protein binding | |
| protein kinase | |
| receptor signaling protein serine/threonine kinase | |
| transcription activator |
| Mus musculus Chromosome position | 8 A3-A4 |
|---|---|
| 8 |
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis | |
| B cell receptor signaling pathway | |
| Chronic myeloid leukemia | |
| Insulin signaling pathway | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Type II diabetes mellitus | |
| Small cell lung cancer | |
| Prostate cancer |
| Rattus norvegicus Chromosome position | 16q12.5 |
|---|
| Bos taurus Chromosome position | 27 |
|---|