| URN | urn:agi-llid:4790 |
|---|---|
| Total Entities | 0 |
| Connectivity | 710 |
| Name | Nfkb1 |
| Description | nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 |
| Notes | gene encodes a 105 kD protein that can be processed to create a 50 kD protein; the larger protein is a Rel protein-specific transcription inhibitor and the smaller protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex [RGD] |
| Ariadne Ontology | NF-kB |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | nucleic acid binding transcription factor activity |
|---|---|
| heat shock protein binding | |
| protein homodimerization activity | |
| DNA binding | |
| regulatory region DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region sequence-specific DNA binding | |
| double-stranded DNA binding | |
| transcription regulatory region DNA binding | |
| sequence-specific DNA binding transcription factor activity |
| GO Cellular Component | nucleoplasm |
|---|---|
| nucleolus | |
| protein complex | |
| I-kappaB-NF-kappaB complex | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus |
| GO Biological Process | response to bacterium |
|---|---|
| positive regulation of canonical Wnt receptor signaling pathway | |
| signal transduction | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of cellular protein metabolic process | |
| negative regulation of vitamin D biosynthetic process | |
| negative regulation of interleukin-12 biosynthetic process | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of macrophage derived foam cell differentiation | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| cellular response to interleukin-1 | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| innate immune response | |
| response to copper ion | |
| response to oxidative stress | |
| inflammatory response | |
| negative regulation of cytokine production | |
| negative regulation of cholesterol transport | |
| positive regulation of type I interferon production | |
| positive regulation of lipid storage | |
| positive regulation of hyaluronan biosynthetic process | |
| negative regulation of calcidiol 1-monooxygenase activity | |
| lymph node development | |
| membrane protein intracellular domain proteolysis |
| Pathway | nuclear factor kappa B signaling pathway |
|---|---|
| nuclear factor kappa B signaling pathway | |
| nuclear factor kappa B signaling pathway |
| Group | NF-kB |
|---|---|
| response to bacterium | |
| positive regulation of canonical Wnt receptor signaling pathway | |
| signal transduction | |
| T cell receptor signaling pathway | |
| toll-like receptor signaling pathway | |
| toll-like receptor 2 signaling pathway | |
| toll-like receptor 3 signaling pathway | |
| toll-like receptor 4 signaling pathway | |
| MyD88-dependent toll-like receptor signaling pathway | |
| MyD88-independent toll-like receptor signaling pathway | |
| toll-like receptor 1 signaling pathway | |
| TRIF-dependent toll-like receptor signaling pathway | |
| Toll signaling pathway | |
| nerve growth factor receptor signaling pathway | |
| positive regulation of transcription, DNA-dependent | |
| positive regulation of transcription from RNA polymerase II promoter | |
| negative regulation of cellular protein metabolic process | |
| negative regulation of vitamin D biosynthetic process | |
| negative regulation of interleukin-12 biosynthetic process | |
| negative regulation of transcription, DNA-dependent | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of transcription, DNA-dependent | |
| positive regulation of NF-kappaB transcription factor activity | |
| negative regulation of apoptotic process | |
| positive regulation of macrophage derived foam cell differentiation | |
| transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| cellular response to interleukin-1 | |
| cellular response to mechanical stimulus | |
| apoptotic process | |
| innate immune response | |
| response to copper ion | |
| response to oxidative stress | |
| inflammatory response | |
| negative regulation of cytokine production | |
| negative regulation of cholesterol transport | |
| positive regulation of type I interferon production | |
| positive regulation of lipid storage | |
| positive regulation of hyaluronan biosynthetic process | |
| negative regulation of calcidiol 1-monooxygenase activity | |
| lymph node development | |
| membrane protein intracellular domain proteolysis | |
| nucleic acid binding transcription factor activity | |
| heat shock protein binding | |
| protein homodimerization activity | |
| DNA binding | |
| regulatory region DNA binding | |
| sequence-specific DNA binding | |
| transcription regulatory region sequence-specific DNA binding | |
| double-stranded DNA binding | |
| transcription regulatory region DNA binding | |
| sequence-specific DNA binding transcription factor activity | |
| nucleoplasm | |
| nucleolus | |
| protein complex | |
| I-kappaB-NF-kappaB complex | |
| cytoplasm | |
| mitochondrion | |
| cytosol | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| Source | Curated |
|---|---|
| GO component |
| MedScan ID | 4790 |
|---|
| Hugo ID | 7794 |
|---|
| Human chromosome position | 4q24 |
|---|
| LocusLink ID | 4790 |
|---|---|
| 18033 | |
| 81736 | |
| 616115 | |
| 565756 |
| Alias | p50 |
|---|---|
| KBF1 | |
| p105 | |
| EBP-1 | |
| NF-kB1 | |
| NFKB-p50 | |
| NFkappaB | |
| NF-kappaB | |
| NFKB-p105 | |
| NF-kappa-B | |
| nuclear factor NF-kappa-B p105 subunit | |
| NF-kappabeta | |
| DNA binding factor KBF1 | |
| DNA-binding factor KBF1 | |
| nuclear factor NF-kappa-B p50 subunit | |
| nuclear factor kappa-B DNA binding subunit | |
| p50/p105 | |
| NF-kappaB1 | |
| NF kappaB1 | |
| NF-kappaB p50 | |
| p50 subunit of NF kappaB | |
| p50 subunit of NF-kappaB | |
| nuclear factor kappaB p50 | |
| nuclear factor-kappaB p50 | |
| NF-kappa-B1 p84/NF-kappa-B1 p98 | |
| nuclear factor of kappa light chain gene enhancer in B-cells 1, p105 | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | |
| NF-kB | |
| nuclear factor kappa B p105 subunit | |
| nuclear factor kappa-B, subunit p50 | |
| nuclear factor kappa-B, subunit I | |
| nuclear factor kappa-B, subunit 1 | |
| nuclear factor NFkappaB p105 subunit | |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | |
| nuclear factor NFkappaB p50 subunit | |
| Nuclear factor of kappa light chain gene enhancer in B-cells 1 (p105) | |
| OTTMUSP00000018024 | |
| p105 subunit of NF kappaB | |
| p105 subunit of NFkappaB | |
| p50 subunit of NFkappaB | |
| NFKB1 | |
| MGC54151 | |
| DKFZp686c01211 | |
| DNA-binding factor KBF I | |
| EBP I | |
| NF-kappaB p50 subunit | |
| NF-KB I | |
| NFkappaB I | |
| NF-kappaB I | |
| NFkappaB p105 | |
| KBF I | |
| NFKB I | |
| NF-kappaB p105 | |
| NFkappaB1 | |
| NFkappaB p50 subunit | |
| NFkappaB p50 | |
| NF-kappaB p105 subunit | |
| NFkappaB p105 subunit | |
| nuclear factor kappa-B, subunit | |
| NF-kappa-B I | |
| NF-kappa-B p50 | |
| NF-kappa-B1 | |
| NF-KB1s | |
| NF-KB Is | |
| subunit of NF-kappaB | |
| P(50) | |
| Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | |
| NF-kB1 precursor protein | |
| chromosome | |
| scaffold |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Bos taurus | |
| Danio rerio |
| OMIM ID | 164011 |
|---|
| Unigene ID | Hs.618430 |
|---|---|
| Mm.256765 | |
| Rn.2411 | |
| Hs.654408 | |
| Hs.431926 | |
| Bt.60919 | |
| Dr.47468 |
| KEGG ID | hsa:4790 |
|---|---|
| mmu:18033 | |
| rno:81736 |
| Swiss-Prot Accession | P19838 |
|---|---|
| P25799 | |
| F1LQH2 | |
| Q63369 | |
| A8K5Y5 | |
| B3KVE8 | |
| Q68D84 | |
| Q86V43 | |
| Q8N4X7 | |
| Q9NZC0 | |
| B2RRQ6 | |
| Q3TZE8 | |
| Q3V2V6 | |
| Q6TDG8 | |
| Q75ZL1 | |
| Q80Y21 | |
| Q8C712 | |
| Q61723 |
| GO ID | 0003690 |
|---|---|
| 0031072 | |
| 0001071 | |
| 0042803 | |
| 0000975 | |
| 0003700 | |
| 0044212 | |
| 0000976 | |
| 0002755 | |
| 0002756 | |
| 0050852 | |
| 0035666 | |
| 0008063 | |
| 0006915 | |
| 0071347 | |
| 0071260 | |
| 0006954 | |
| 0045087 | |
| 0031293 | |
| 0043066 | |
| 0010956 | |
| 0032269 | |
| 0032375 | |
| 0001818 | |
| 0045083 | |
| 0000122 | |
| 0010957 | |
| 0048011 | |
| 0051092 | |
| 0090263 | |
| 1900127 | |
| 0010884 | |
| 0010744 | |
| 0045944 | |
| 0045893 | |
| 0032481 | |
| 0009617 | |
| 0046688 | |
| 0006979 | |
| 0034130 | |
| 0034134 | |
| 0034138 | |
| 0034142 | |
| 0002224 | |
| 0006366 | |
| 0033256 | |
| 0005737 | |
| 0005829 | |
| 0005739 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0003677 | |
| 0043565 | |
| 0048535 | |
| 0045892 | |
| 0006355 | |
| 0007165 | |
| 0006351 | |
| 0043234 | |
| 0006916 | |
| 0010843 | |
| 0010553 | |
| 0045941 | |
| 0003779 | |
| 0016566 | |
| 0016563 | |
| 0010552 | |
| 0045449 | |
| 0006350 | |
| 0005515 | |
| 0045834 | |
| 0046983 | |
| 0019733 | |
| 0009618 |
| PIR ID | A37867 |
|---|---|
| A35697 |
| Swiss-Prot ID | NFKB1_HUMAN |
|---|---|
| NFKB1_MOUSE | |
| B2RRQ6_MOUSE |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| IPI ID | IPI00292537 |
|---|---|
| IPI00788987 | |
| IPI00113873 | |
| IPI00221649 | |
| IPI00719865 | |
| IPI00719890 | |
| IPI00742428 | |
| IPI00742440 | |
| IPI01007628 | |
| IPI00221651 | |
| IPI00474698 | |
| IPI00373434 | |
| IPI00561207 |
| Mouse chromosome position | 3 68.9 cM |
|---|
| Rat chromosome position | 2q43 |
|---|
| Homologene ID | 2971 |
|---|
| MGI ID | 97312 |
|---|
| RGD ID | 70498 |
|---|
| Primary Cell Localization | Nucleus |
|---|
| Homo sapiens Chromosome position | 4q24 |
|---|
| Microarray ID | 98427_s_at |
|---|---|
| 209239_at |
| FunctionalClass | protein binding |
|---|---|
| specific transcriptional repressor | |
| transcription factor | |
| DNA binding | |
| actin binding | |
| double-stranded DNA binding | |
| heat shock protein binding | |
| protein dimerization | |
| sequence-specific DNA binding | |
| transcriptional activator | |
| transcription activator |
| Mus musculus Chromosome position | 3 68.9 cM |
|---|
| KEGG pathway | Adipocytokine signaling pathway |
|---|---|
| Apoptosis | |
| B cell receptor signaling pathway | |
| Chronic myeloid leukemia | |
| MAPK signaling pathway | |
| Pancreatic cancer | |
| T cell receptor signaling pathway | |
| Toll-like receptor signaling pathway | |
| Calcium signaling pathway | |
| Prostate cancer | |
| Small cell lung cancer |
| Rattus norvegicus Chromosome position | 2q43 |
|---|
| Bos taurus Chromosome position | 6 |
|---|