Protein Tab3

URN	urn:agi-llid:257397
Total Entities	0
Connectivity	65
Name	Tab3
Description	TGF-beta activated kinase 1/MAP3K7 binding protein 3
Notes	The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GO Biological Process	activation of MAPK activity
	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
	nucleotide-binding oligomerization domain containing signaling pathway
	I-kappaB kinase-NF-kappaB cascade
	stress-activated MAPK cascade
	JNK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 3 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	MyD88-independent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	TRIF-dependent toll-like receptor signaling pathway
	Toll signaling pathway
	positive regulation of NF-kappaB transcription factor activity
	phosphorylation
	innate immune response

Pathway	NOD-like receptor signaling pathway
	nuclear factor kappa B signaling pathway
	tumor necrosis factor signaling pathway
	tumor necrosis factor mediated signaling pathway

Group	activation of MAPK activity
	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
	nucleotide-binding oligomerization domain containing signaling pathway
	I-kappaB kinase-NF-kappaB cascade
	stress-activated MAPK cascade
	JNK cascade
	toll-like receptor signaling pathway
	toll-like receptor 2 signaling pathway
	toll-like receptor 3 signaling pathway
	toll-like receptor 4 signaling pathway
	MyD88-dependent toll-like receptor signaling pathway
	MyD88-independent toll-like receptor signaling pathway
	toll-like receptor 1 signaling pathway
	TRIF-dependent toll-like receptor signaling pathway
	Toll signaling pathway
	positive regulation of NF-kappaB transcription factor activity
	phosphorylation
	innate immune response
	metal ion binding
	zinc ion binding
	kinase activity
	endosome membrane
	plasma membrane
	intracellular
	cytosol

MedScan ID	257397

Hugo ID	30681

Human chromosome position	Xp21.2

LocusLink ID	257397
	66724

Alias	NAP1
	MAP3K7IP3
	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
	TAB-3
	TAK1-binding protein 3
	NFkB activating protein 1
	NF-kappa-B-activating protein 1
	TGF-beta-activated kinase 1-binding protein 3
	mitogen-activated protein kinase kinase kinase 7 interacting protein 3
	mKIAA4135
	RP23-181A7.1
	4921526G09Rik
	mitogen activated protein kinase kinase kinase 7 interacting protein 3
	mitogen-activated protein kinase kinase kinase 7-interacting protein 3
	OTTMUSP00000019469
	TAB3
	TAK1 binding protein 3
	TAK1-binding protein III
	OTTHUMP00000023112
	TGF-beta activated kinase 1/MAP3K7 binding protein 3
	MGC45404
	KIAA4135
	4921526G09
	NFkB activating protein I

Organism	Homo sapiens
	Mus musculus

OMIM ID	300480

Unigene ID	Hs.188256
	Mm.119646

KEGG ID	hsa:257397
	mmu:66724

Swiss-Prot ID	TAB3_MOUSE
	TAB3_HUMAN

Mouse chromosome position	X

Homologene ID	17673

MGI ID	1913974